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2008 Fiscal Year Final Research Report

Study on the lipid biosynthesis and the related phathology in. hepatitis C virus infection

Research Project

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Project/Area Number 19590473
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionOsaka University

Principal Investigator

MORIISHI Koji  Osaka University, 微生物病研究所, 准教授 (90260273)

Co-Investigator(Kenkyū-buntansha) MORIISHI Koji  大阪大学, 微生物病研究所, 准教授 (90260273)
Project Period (FY) 2007 – 2008
Keywords病原性 / ウイルス / 感染症 / 発現制御 / C型肝炎
Research Abstract

C型肝炎ウイルス(HCV)コア蛋白質は、細胞内のラフト様構造にも局在してるが、ウイルス感染環あるいは病原性における役割はわかっていない。本研究によって、膜内切断を受けたコア蛋白質はウイルス粒子形成に必要であることが示された。また、コア蛋白質とPA28γの発現によって脂質代謝が増強される現象は、インターフェロン抵抗性を示すC型肝炎患者で多く認められるコア蛋白質変異によって減弱していた。以上のことから、コア蛋白質を修飾する宿主蛋白質を標的にした薬剤が、抗HCV薬として期待出来ることが分かった

  • Research Products

    (35 results)

All 2008 2007

All Journal Article (11 results) Presentation (24 results)

  • [Journal Article] 2008. Hepatitis C virus core protein : its coordinate roles with PA28gamma in metabolic abnormality and carcinogenicity in the liver2008

    • Author(s)
      Mori, Y., K. Moriishi, and Y. Matsuura
    • Journal Title

      Int. J. Biochem. Cell Biol 40

      Pages: 1437-1442

  • [Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation2008

    • Author(s)
      Okamoto, K., Y. Mori, Y. Komoda, T. Okamoto, M. Okochi, M. Takeda, T. Suzuki, K. Moriishi, and Y. Matsuura
    • Journal Title

      J. Virol 82

      Pages: 8349-8361

  • [Journal Article] A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication2008

    • Author(s)
      Okamoto, T., H. Omori, Y. Kaname, T. Abe, Y. Nishimura, T. Suzuki, T. Miyamura, T. Yoshimori, K. Moriishi, and Y. Matsuura
    • Journal Title

      J. Virol 82

      Pages: 3480-3489

  • [Journal Article] Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication2008

    • Author(s)
      Taguwa, S., T. Okamoto, T. Abe, Y. Mori, T. Suzuki, K. Moriishi, and Y. Matsuura
    • Journal Title

      J. Virol 82

      Pages: 2631-2641

  • [Journal Article] Critical role of PA28γ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis2007

    • Author(s)
      Moriishi K., Mochizuki R., Moriya K., Miyamoto H., Mori Y., Abe T., Murata S., Tanaka K., Miyamura T., Suzuki T., Koike K., and Matsuura Y
    • Journal Title

      Proc. Natl Acad. Sci. USA 104

      Pages: 1661-1666

  • [Journal Article] Hepatitis C Virus Nonstructural Protein 5A Modulates TLR-MyD88-Dependent Signaling Pathway in the Macrophage Cell Lines2007

    • Author(s)
      Abe T., Kaname Y., Hamamoto I., Tsuda Y., Wen X., Taguwa S., Moriishi K., Takeuchi O., Kawai T., Kanto T., Hayashi N., Akira S., and Matsuura Y
    • Journal Title

      J. Virol 81

      Pages: 8953-8966

  • [Journal Article] Processing of Capsid Protein by Cathepsin L Plays a Crucial Role in Replication of the Japanese Encephalitis Virus in Neural and Macrophage Cells2007

    • Author(s)
      Mori Y., Yamashita T., Tanaka Y., Tsuda Y., Abe T., Moriishi K., and Matsuura Y
    • Journal Title

      J. Virol 81

      Pages: 8477-8487

  • [Journal Article] Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins2007

    • Author(s)
      Tani H., Komoda Y., Matsuo E., Suzuki K., Hamamoto I., Yamashita T., Moriishi K., Fujiyama K., Kanto T., Hayashi N., Owsianka A., Patel A.H., Whitt M.A., and Matsuura Y
    • Journal Title

      J. Virol 81

      Pages: 8601-8612

  • [Journal Article] Host factors involved in the replication of hepatitis C virus2007

    • Author(s)
      Moriishi K., and Matsuura Y
    • Journal Title

      Rev. Med. Virol. 17

      Pages: 343-354

  • [Journal Article] Evaluation systems for anti HCV drugs2007

    • Author(s)
      Moriishi K., and Matsuura Y
    • Journal Title

      Adv. Drug Deliv. Rev 59

      Pages: 1213-1221

  • [Journal Article] Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein2007

    • Author(s)
      Miyamoto H., Moriishi K, Moriya K, Murata S, Tanaka K, Suzuki T, Miyamura T, Koike K, Matsuura Y
    • Journal Title

      J. Virol 81

      Pages: 1727-1735

  • [Presentation] C 型肝炎ウイルス感染によるTLR 経路を介した炎症性ケモカインIP- 10 の過剰産生2008

    • Author(s)
      阿部隆之、要祐喜、森石恆司、考藤達哉、林紀夫、松浦善治
    • Organizer
      第56回日本ウイルス学会総会(ワークショップ)
    • Place of Presentation
      岡山
    • Year and Date
      20081000
  • [Presentation] 日本脳炎ウイルスの細胞侵入におけるセラミドの関与2008

    • Author(s)
      谷英樹、泉貴之、寒原裕登、要祐喜、森嘉生、森石恆司、松浦善治
    • Organizer
      第56回日本ウイルス学会総会(一般口演)
    • Place of Presentation
      岡山
    • Year and Date
      20081000
  • [Presentation] C 型肝炎ウイルスの複製におけるhB-ind1 のコシャペロン活性2008

    • Author(s)
      田鍬修平、阿部隆之、森嘉生、森石恆司、松浦善治
    • Organizer
      第56回日本ウイルス学会総会(一般口演)
    • Place of Presentation
      岡山
    • Year and Date
      20081000
  • [Presentation] C 型肝炎ウイルス感染におけるプロテアソーム活性化蛋白質PA28γの役割2008

    • Author(s)
      森石恆司、松浦善治
    • Organizer
      第56回日本ウイルス学会総会(一般口演)
    • Place of Presentation
      岡山
    • Year and Date
      20081000
  • [Presentation] ヒトVAP-CはC 型肝炎ウイルスの複製を抑制する2008

    • Author(s)
      久木原博、森石恆司、松浦善治
    • Organizer
      第56回日本ウイルス学会総会(一般口演)
    • Place of Presentation
      岡山
    • Year and Date
      20081000
  • [Presentation] Ceramide plays a crucial role on theentry of Japanese encephalitis virus2008

    • Author(s)
      Tani, H, Izumi, T., Kanbara, H., Kaname, Y., Mori, Y., Moriishi, K., Matsuura, Y.
    • Organizer
      15th International Symposium on Hepatitis C virus & related viruses, San Antonio, USA
    • Year and Date
      20081000
  • [Presentation] HCV infection induces IP-10 production through the TLR signaling pathway2008

    • Author(s)
      Abe, T., Kaname, Y., Moriishi, K., Kanto, T., Hayashi, N., Matsuura, Y
    • Organizer
      15th International Symposium on Hepatitis Cvirus & related viruses, San Antonio, USA
    • Year and Date
      20081000
  • [Presentation] Human vesicule-associated membrane protein-associated protein subtype Cinhibits HCV replication2008

    • Author(s)
      Kukihara, H., Moriishi, K., Matsuura, Y.
    • Organizer
      15th International Symposium on Hepatitis Cvirus & related viruses, San Antonio, USA
    • Year and Date
      20081000
  • [Presentation] Establishment of an indicator cell line that detects the replication of HCV insera from hepatitis C patients2008

    • Author(s)
      Tanaka, Y., Mori, Y., Tani, H., Abe, T., Moriishi, K., Matsuura, Y.
    • Organizer
      15th International Symposium on Hepatitis Cvirus & related viruses, San Antonio, USA
    • Year and Date
      20081000
  • [Presentation] Proteasome activator PA28gamma is required for efficient growth of hepatitis C virus2008

    • Author(s)
      Moriishi, K., Matsuura, Y
    • Organizer
      15th International Symposium on Hepatitis C virus & related viruses, San Antonio, USA
    • Year and Date
      20081000
  • [Presentation] C 型肝炎ウイルス感染と肝発癌2008

    • Author(s)
      森石恆司、松浦善治
    • Organizer
      第82回日本感染症学会総会、教育講演
    • Place of Presentation
      松江
    • Year and Date
      20080400
  • [Presentation] C 型肝炎ウイルスゲノム複製に関与する宿主蛋白質B-ind1 の機能解析2007

    • Author(s)
      田鍬修平、岡本 徹、阿部隆之、森 嘉生、森石恆司、松浦善治
    • Organizer
      第55回日本ウイルス学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20071021-23
  • [Presentation] C 型肝炎ウイルスによるTLR シグナル伝達経路を介した炎症性ケモカインIP-10 の過剰産生2007

    • Author(s)
      阿部隆之、森石恆司、考藤達哉、林紀夫、審良静男、松浦善治
    • Organizer
      第55回日本ウイルス学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20071021-23
  • [Presentation] シュードタイプと組換え水疱性口内炎ウイルスを用いたC 型肝炎ウイルスの感染機構の解析2007

    • Author(s)
      谷英樹、菰田泰正、鈴木健介、山下哲生、稲田大彦、森石恆司、考藤達哉、林紀夫、松浦善治
    • Organizer
      第55回日本ウイルス学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20071021-23
  • [Presentation] C 型肝炎ウイルスゲノム複製におけるFKBP8 の役割2007

    • Author(s)
      岡本徹、森石恆司、松浦善治
    • Organizer
      第55回日本ウイルス学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20071021-23
  • [Presentation] C型肝炎ウイルスコア蛋白質のシグナルペプチドペプチダーゼによるプロセッシングの生物学的意義2007

    • Author(s)
      森嘉生、岡本貴世子、岡本徹、菰田泰正、鈴木哲朗、森石恆司、松浦善治
    • Organizer
      第55回日本ウイルス学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20071021-23
  • [Presentation] Matsuura : Human butyrate-induced transcript 1 interacts with HCV NS5A and regulates HCV replication2007

    • Author(s)
      Shuhei Taguwa, Toru Okamoto, Takayuki Abe, Kohji Moriishi, and Yoshiharu
    • Organizer
      14th International Meeting on HCV and Related Viruses, Glasgow
    • Year and Date
      20070909-13
  • [Presentation] Enhancement of IP-10 expression via TLR signaling pathway in cells expressing HCV proteins2007

    • Author(s)
      Takayuki Abe, Yuuki Kaname, Xiaoyu Wen, Kohji Moriishi, Tatsuya Kanto, Norio Hayashi, and Yoshiharu Matsuura
    • Organizer
      4th International Meeting on HCV and Related Viruses, Glasgow
    • Year and Date
      20070909-13
  • [Presentation] Replication-competent recombinantvesicular stomatitis virus encoding HCV envelope proteins.2007

    • Author(s)
      Hideki Tani, Yasumasa Komoda, Eiko Matsuo, Kensuke Suzuki, Itsuki Hamamoto, Tetsuo Yamashita, Kohji Moriishi, Kazuhito Fujiyama, Tatsuya Kanto, Norio Hayashi, Ania Owsianka, Arvind H. Patel, Michael A. Whitt, and Yoshiharu Matsuura
    • Organizer
      4th International Meeting on HCV and Related Viruses, Glasgow
    • Year and Date
      20070909-13
  • [Presentation] Intramembrane processing by SPP regulates membrane localization of HCV core protein and viral propagation.2007

    • Author(s)
      Yoshio Mori, Kiyoko Okamoto, Toru Okamoto, Yasumasa Komoda, Masayasu Okochi, Masatoshi Takeda, Tetsuro Suzuki, Kohji Moriishi, and Yoshiharu Matsuura
    • Organizer
      4th International Meeting on HCV and Related Viruses, Glasgow
    • Year and Date
      20070909-13
  • [Presentation] FKBP8 Plays a Crucial Role in the Replication of Hepatitis C Virus2007

    • Author(s)
      Toru Okamoto, Kohji Moriishi, and Yoshiharu Matsuura
    • Organizer
      HEP DART 2007
    • Place of Presentation
      Hawaii
    • Year and Date
      20070909-13
  • [Presentation] Critical role of PA28 γ-proteasome pathway in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis2007

    • Author(s)
      Kohji Moriishi
    • Organizer
      7th Awaji International forum on infection and immunology
    • Place of Presentation
      Awaji
    • Year and Date
      20070901-05
  • [Presentation] HCV コア蛋白質による脂肪酸合成促進と肝細胞癌発症におけるPA28γ の役割2007

    • Author(s)
      森石恆司、森屋恭爾、村田茂穂、田中啓二、鈴木哲朗、宮村達男、小池和彦、松浦善治
    • Organizer
      第43回日本肝臓学会総会ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      20070531-0601
  • [Presentation] Critical role of REGγ/PA28γ-proteasome pathway in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis2007

    • Author(s)
      Kohji Moriishi
    • Organizer
      2007 International RIMD-CVRDC Joint Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2007-12-18

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Published: 2010-06-10   Modified: 2016-04-21  

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