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2008 Fiscal Year Final Research Report

The role of transcription factor IRF-3 in cardiac disease

Research Project

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Project/Area Number 19590492
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

YANAI Hideyuki  The University of Tokyo, 大学院・医学系研究科, 助教 (70431765)

Co-Investigator(Kenkyū-buntansha) TSUSHIMA Kensuke  東京大学, 大学院・医学系研究科, 助教 (50436482)
Project Period (FY) 2007 – 2008
Keywords心疾患 / IRF / アンギオテンシン / TLR / サイトカイン
Research Abstract

心肥大病態モデルマウスに昇圧剤アンジオテンシン(Ang)IIを投与すると、野生型マウスでは高血圧性心疾患に見られる心臓の線維化が進行するがIRF(IFN regulatory factor)ファミリー遺伝子Irf3欠損マウスでは線維化が起きない事、また骨髄系由来細胞のIRF3がAngII 下流でセリン残基リン酸化を受け活性化し、線維化に関与する事を見いだした。
さらにDNAマイクロアレイ解析によりAngII-IRF3 経路のケモカイン・心疾患関連遺伝子誘導への関与を明らかとした。

  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (1 results)

  • [Journal Article] Regulation of the cytosolic DNA-sensingsystem in innate immunity : a current view2009

    • Author(s)
      Yanai H, Savitsky D, Tamura T, Taniguchi T.
    • Journal Title

      Curr Opin Immunol 1

      Pages: 17-22

    • Peer Reviewed
  • [Journal Article] Critical role for constitutive type Iinterferon signaling in the prevention ofcellular transformation2009

    • Author(s)
      Chen HM, Tanaka N, Mitani Y, Oda E,Nozawa H, Chen JZ, Yanai H, Negishi H, ChoiMK, Iwasaki T, Yamamoto H, Taniguchi T, Takaoka A.
    • Journal Title

      Cancer Sci 100

      Pages: 449-456

    • Peer Reviewed
  • [Journal Article] Regulation ofinnate immune responses by DAI(DLM-1/ZBP1) and other DNA-sensingmolecules2008

    • Author(s)
      Wang Z., Choi MK., Ban T., Yanai H., Negishi H., Lu Y., Tamura T., Takaoka A., Nishikura K. and Taniguchi T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 5477-5482

    • Peer Reviewed
  • [Journal Article] Acritical link between Toll-like receptor 3 andtype II interferon signaling pathways inantiviral innate immunity2008

    • Author(s)
      Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T,Kaisho T, Taya C, Taniguchi T, Honda K.
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 20446-20451

    • Peer Reviewed
  • [Journal Article] A cell-type-specificrequirement for IFN regulatory factor 5(IRF5) in Fas-induced apoptosis2008

    • Author(s)
      Couzinet A., Tamura K., Chen HM.,Nishimura K., Wang Z., Morishita Y., Takeda K., Yagita H., Yanai H., Taniguchi T. and Tamura T.
    • Journal Title

      Proc. Natl.Acad. Sci. U.S.A. 105

      Pages: 2556-2561

    • Peer Reviewed
  • [Journal Article] The IRF family transcriptionfactors in immunity and oncogenesis2008

    • Author(s)
      Tamura T., Yanai H., Savitsky D. and Taniguchi T.
    • Journal Title

      Annu.Rev. Immunol 26

      Pages: 535-584

    • Peer Reviewed
  • [Journal Article] IRF ファミリー転写因子と生体防御シグナル2008

    • Author(s)
      柳井秀元・谷口維紹
    • Journal Title

      蛋白質核酸酵素(共立出版) 53

      Pages: 1231-1238

  • [Journal Article] Effects of hydrophobic amino acidsubstitution in Pleurotus ostreatusproteinase A inhibitor 1 on its structure andfunctions as protease inhibitor andintramolecular chaperone2007

    • Author(s)
      Kojima S., Iwahara A., Hisano Y. and Yanai H.
    • Journal Title

      Protein Eng. Des. Sel 103

      Pages: 211-217

    • Peer Reviewed
  • [Journal Article] Role of IFN regulatory factor 5 transcription factor in antiviral immunityand tumor suppression. Proc2007

    • Author(s)
      Yanai H., Chen HM., Inuzuka T., Kondo S.,Mak TW., Takaoka A., Honda K. and Taniguchi T.
    • Journal Title

      Natl. Acad. Sci.USA 104

      Pages: 3402-3407

    • Peer Reviewed
  • [Journal Article] DAI (DLM-1/ZBP1) is acytosolic DNA sensor and an activator ofinnate immune response2007

    • Author(s)
      Takaoka A., Wang A., Choi MK., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M.,Kodama T., Honda K., Ohba Y. and Taniguchi T.
    • Journal Title

      Nature 448

      Pages: 501-505

    • URL

      Nature

    • Peer Reviewed
  • [Presentation] Regulation of innate immuneresponses by DAI(DLM-1/ZBP1) and other DNA-sensing molecules2008

    • Author(s)
      柳井秀元
    • Organizer
      第38回日本免疫学会総会・シンポジウム
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-02

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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