Mechanisms for the differentiation and maturation of cells of the innate immune system and their dysregulation underlying abnormal acquired immunity

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Shinshu University
• Principal Investigator: TAKI Shinsuke Shinshu University, 大学院・医学系研究科, 教授 (50262027)
• Project Period (FY): 2007 – 2008
• Keywords: サイトカイン / NK細胞 / 炎症 / 好塩基球

Research Abstract

本研究では、遺伝子発現調節因子であるインターフェロン制御因子2(IRF-2)を遺伝的に欠損するマウスにおいて、第4および10染色体上の1型インターフェロン(IFN)応答を調節する遺伝子座が皮膚炎症の発症に影響を与えること、それはCD8+T細胞の2型IFN(IFN-g)産生の制御を介していることを明らかにした。一方、活性化ナチュラルキラー細胞がB細胞の分化を抑制していること、その機構にもIFN-gが関与していることを見いだした。

Research Products

• [Journal Article] Fc receptor g-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils (2009)
  • Author(s): Hida, S, Yamasaki, S, Sakamoto, Y, Takamoto, M, Obata, K, Takai, T, Karasuyama, H, Sugane, K, Saito, T, Taki, S
  • Journal Title: Nature Immunol 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways (2009)
  • Author(s): Nagumo, H, Abe, J, Kano, H, Taki, S, Yamazaki, K, Yamazaki, T, Kobayashi, N, Koike, K, Sugane, K, Saito, H, Agematsu, K
  • Journal Title: Cell. Immunol 256 Pages: 56-63
  • Peer Reviewed
• [Journal Article] STAT6 signalling is important in CD8^+ T-cell activation and defence against Toxoplasma gondii infection in the brain (2009)
  • Author(s): Jin, D, Takamoto, M, Hu, T, Taki, S, Sugane, K
  • Journal Title: Immunology 127 Pages: 187-195
  • Peer Reviewed
• [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1^+B220^+ NK cells Biochem. Biophys. Res (2008)
  • Author(s): Nakajima, S, Hida, S, Taki, S
  • Journal Title: Commun 369 Pages: 1139-1143
  • URL: http://hdl.handle.net/10091/1090
  • Peer Reviewed
• [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling (2008)
  • Author(s): Mizutani, T, Tsuji, K, Ebihara, Y, Taki, S, Ohba, Y, Taniguchi, T, Honda, K
  • Journal Title: Exp. Hematol 36 Pages: 255-364
  • Peer Reviewed
• [Journal Article] Genetic control directed towards spontaneous IFN-α/β responses and downstream IFN-γ expression influences the pathogenesis of a murine psoriasis-like skin disease (2008)
  • Author(s): Arakura, F, Hida, S, Ichikawa, E, Yajima, C, Nakajima, S, Saida, T, Taki, S
  • Journal Title: J. Immunol 179 Pages: 3249-3257
  • Peer Reviewed
• [Presentation] Basophils affect the homeostasis regulation of Th1/Th2 balance (2007)
  • Author(s): Taki, S
  • Organizer: World allergy congress 2007
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2007-12-01
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.html