Immune regulation of intestinal homeostasis by NOD2 activation

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: WATANABE Tomohiro Kyoto University, 医学研究科, 助教 (40444468)
• Project Period (FY): 2007 – 2008
• Keywords: サイトカイン / 自然免疫

Research Abstract

Nucleotide binding oligomerization domain 2(NOD2)の活性化が腸内細菌によるToll-like receptor(TLR)の活性化を抑制することにより、腸炎の発症を未然に防止していること及びその分子機序を明らかにした。

Research Products

• [Journal Article] Muramyl dipeptide activation of nucleotide binding oligomerization domain 2 protects mice from experimental colitis (2008)
  • Author(s): Watanabe T, Asano N, Murray PJ, Ozato K, Tailor P, Fuss IJ, Kitani A, Strober W.
  • Journal Title: Journal of Clinical Investigation 118 Pages: 545-59
  • Peer Reviewed
• [Journal Article] The molecular basis of NOD2 susceptibility mutations in Crohn's disease (2008)
  • Author(s): Strober W, Kitani A, Fuss IJ, Asano N, Watanabe T.
  • Journal Title: Mucosal Immunology 1 Pages: 5-9
  • Peer Reviewed
• [Journal Article] NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis-induction. (2007)
  • Author(s): Yang Z, Fuss IJ, Watanabe T, Asano N, Davey MP, Rosenbaum JT, Strober W, and Kitani A.
  • Journal Title: Gastroenterology 133 Pages: 1510-21
  • Peer Reviewed
• [Presentation] Muramyl didpeptide activation of Nucleotide binding oligomerization domain 2 protects mice from experimental colitis (2008)
  • Author(s): Tomohiro Watanabe
  • Organizer: Muramyl didpeptide activation of Nucleotide binding oligomerization domain 2 protects mice from experimental colitis
  • Place of Presentation: Kyoto. Symposium : Mucosal immunology
  • Year and Date: 20081201-03