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2009 Fiscal Year Self-evaluation Report

Standardization of taylor-made chemotherapy based on pharmacokinetics and pharmacogenomics

Research Project

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Project/Area Number 19590533
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKyoto University

Principal Investigator

ISHIGURO Hiroshi  Kyoto University, 医学研究科, 講師 (20422925)

Project Period (FY) 2007 – 2011
Keywords臨床薬理学
Research Abstract

抗がん剤の多くは、肝臓や腎臓で代謝・排泄されるが、体表面積(BSA)がこれらの臓器機能と相関するというはっきりとした根拠は存在しない。肝臓の代謝酵素(CYPやUGT1A1など)の遺伝子多型や併用薬が薬物動態に影響を及ぼし、その結果として副作用や有効性にも影響することがある。テーラーメード医療として、個々の患者における遺伝子多型や薬物動態を基に個々の患者における効果や副作用の確率を予想して投与量を調整する方法は、理論的に最も単純でかつ確実な方法である。
京都大学大学院医学研究科・医の倫理委員会にて承認された医師主導臨床試験において臨床研究実施計画書(プロトコール)に従って肝代謝の抗がん剤投与がなされた患者の中で、副作用や最大耐量(MTD)との関連が示唆されるAUC(Area Under the Blood Concentration-time Curve)やクリアランス(CL)などの薬物動態因子や薬物代謝酵素の遺伝子多型などの中から、重篤な副作用や最大耐量(MTD)と良く相関するだけでなく、臨床の現場において広く普及が可能な検査法の組み合わせを同定する。

  • Research Products

    (11 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Book (3 results)

  • [Journal Article] Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase ProllLeu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy2010

    • Author(s)
      Kanai M, Yoshioka A, Ishiguro H (12番目/16人), et al
    • Journal Title

      Cancer Epidemiol Vol. 34

      Pages: 189-93

    • Peer Reviewed
  • [Journal Article] Economic evaluation of intensive chemotherapy with prophylactic granulocyte colony-stimulating factor for patients with high-risk early breast cancer in Japan2010

    • Author(s)
      Ishiguro H (1番目/8人), Kondo M, Hoshi SL, et al
    • Journal Title

      Clin Ther Vol. 32

      Pages: 311-26

    • Peer Reviewed
  • [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia2009

    • Author(s)
      Kanai M, Morita S, Ishiguro H (11番目/15人), et al
    • Journal Title

      Ann Oncol Vol. 20

      Pages: 1397-401

    • Peer Reviewed
  • [Journal Article] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim2008

    • Author(s)
      Ishiguro H (1番目/9人), Kitano T, Yoshibayashi H, et al
    • Journal Title

      Ann Oncol Vol. 19

      Pages: 1019

    • Peer Reviewed
  • [Journal Article] Economic evaluation of 21-gene reverse transcriptase-polymerase chain reaction assay in lymph-node-negative, estrogen-receptor-positive, early-stage breast cancer in Japan2008

    • Author(s)
      Kondo M, Hoshi SL, Ishiguro H (3番目/5人), et al
    • Journal Title

      Breast Cancer Res Treat Vol. 112

      Pages: 175-87

    • Peer Reviewed
  • [Presentation] Inter-ethnic variation in the Pharmacodynamic Parrameters of Aromatase Inhibitors : A Retrospective Observational Study2009

    • Author(s)
      Ishiguro H (1番目/6人), Park BW, Bando H, et al
    • Organizer
      20^<th> Asia Pacific Cancer Conference
    • Place of Presentation
      Tsukuba Japan
    • Year and Date
      2009-11-13
  • [Presentation] Right drugs for right target at right dose2009

    • Author(s)
      石黒洋
    • Organizer
      第47回日本乳癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
  • [Presentation] Correlation between docetaxel-induced skin toxicity and the use of steroid and H_2 blockers : A multi-institution survey2009

    • Author(s)
      Kawaguchi K, Ishiguro H (2番目/10人), Morita S, et al
    • Organizer
      American Society of Clinical Oncology Annual Meeting 2009
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-05-31
  • [Book] Bentham Frontiers in Drug Design & Discovery(Important Drug Interactions for Clinical Oncologists)2009

    • Author(s)
      Ishiguro H, Yano I, Toi M
    • Total Pages
      97-21
    • Publisher
      Science Publishers Ltd
  • [Book] Pharmacogenomic Considerations(Breast Cancer Management, in Frontiers in Drug Design & Discovery)2009

    • Author(s)
      Ishiguro H, Yano I, Toi M.
    • Total Pages
      122-34
    • Publisher
      Bentham Science Publishers Ltd
  • [Book] 乳癌レビュー20092009

    • Author(s)
      戸井雅和, 石黒洋
    • Total Pages
      217
    • Publisher
      メディカルレビュー社

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Published: 2011-06-18   Modified: 2016-04-21  

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