2011 Fiscal Year Final Research Report
Standardization of tailor-made chemotherapy based on pharmacokinetics and pharmacogenomics
| Project/Area Number |
19590533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANO Ikuko 京都大学, 薬学研究科, 准教授 (50273446)
YANAGIHARA Kazuhiro 京都大学, 医学研究科, 准教授 (70332731)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 臨床薬理学 |
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| Research Abstract |
Anti-neoplastics metabolized by liver has not only with narrow safety margin but also large inter-individual variation in pharmacokinetics. Dosing based on the knowledge of pharmacogenomics, drug interaction and pharmacokinetics are the most simple and reliable methods. We have conducted several investigator-initiated clinical pharmacology trial under approval of ethics committee of Kyoto University Hospital and searched for possibility for minimizing inter-individual variation in pharmacokinetics.
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