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2008 Fiscal Year Final Research Report

Development of new chemotherapies against liver cancer on the basis of levels of transcription factor ID2

Research Project

  • PDF
Project/Area Number 19590536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionYamaguchi University

Principal Investigator

IIZUKA Norio  Yamaguchi University, 大学院・医学系研究科, 准教授 (80332807)

Project Period (FY) 2007 – 2008
KeywordsID2 / 肝癌 / 転移 / 抗がん剤 / 門脈浸潤
Research Abstract

肝癌(HCC)細胞におけるID2の発現量がヒストン脱アセチル化酵素(HDAC)阻害剤(ソディウムブチレート及びトリコスタチンA)の感受性と関連することを見出し、国内(第31回日本分子生物学会年会)および国際学会(The 19^(th) Conference of the Asian Pacific Association for the Study of the Liver)で発表し、現在、論文を投稿準備中である。

  • Research Products

    (11 results)

All 2009 2008

All Journal Article (8 results) Presentation (3 results)

  • [Journal Article] Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma2009

    • Author(s)
      Moribe T, Iizuka N, et.al.
    • Journal Title

      Int J Cancer 125(2)

      Pages: 388-397

  • [Journal Article] Rapid and quantitative detection of CpG-methylation status using TaqMan PCR combined with methyl-binding-domain polypeptide2009

    • Author(s)
      Kimura N, Moribe T, Iizuka N, et.al.
    • Journal Title

      Clin Biochem 28(Epub ahead of print)

  • [Journal Article] Identification of novel aberrant methylation of BASP1 and SRD5A2 for early diagnosis of hepatocellular carcinoma by genome-wide search2008

    • Author(s)
      Moribe T, Iizuka N, et.al.
    • Journal Title

      Int J Oncol 33(5)

      Pages: 949-58

  • [Journal Article] Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma2008

    • Author(s)
      Hamaguchi T, Iizuka N, et.al.
    • Journal Title

      Int J Oncol 33(4)

      Pages: 725-31

  • [Journal Article] Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma2008

    • Author(s)
      Iida M, Iizuka N, et.al.
    • Journal Title

      Oncol Rep 20(4)

      Pages: 761-5

  • [Journal Article] Translational microarray systems for outcome prediction of hepatocellular carcinoma2008

    • Author(s)
      Iizuka N, Hamamoto Y, Tsunedomi R, Oka M.
    • Journal Title

      Cancer Sci(Review) 99(4)

      Pages: 659-65

  • [Journal Article] A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy2008

    • Author(s)
      Somura H, Iizuka N, et.al.
    • Journal Title

      Oncol Rep 19(2)

      Pages: 489-95

  • [Journal Article] Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor2008

    • Author(s)
      Tsunedomi R, Iizuka N, et.al.
    • Journal Title

      Clin Cancer Res 11

      Pages: 1023-1031

  • [Presentation] Influence of the ID2 on the anti-tumor activity of histone deacetylase inhibitor in hepatocellular carcinoma cells2009

    • Author(s)
      Tsunedomi R, Iizuka N, et.al.
    • Organizer
      The 19^<th>Conference of the Asian Pacific Associationfor the Study of the Liver (APASL)
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      20090214-16
  • [Presentation] 肝細胞癌におけるID2レベルとヒストン脱アセチル化酵素阻害剤感受性2009

    • Author(s)
      原田紗和子、飯塚徳男, 他
    • Organizer
      第111回山口大学医学会学術講演会
    • Place of Presentation
      宇部
    • Year and Date
      2009-02-21
  • [Presentation] Intracellular ID2 levels and histone deacetylase inhibitors in hepatocellular carcinoma cells2008

    • Author(s)
      Harada S, Iizuka N et.al.
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28

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Published: 2010-06-10   Modified: 2016-04-21  

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