2009 Fiscal Year Final Research Report
Novel approach to vascular injury by targeting amino acid transporter LAT1
| Project/Area Number |
19590543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyorin University |
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Principal Investigator |
KOZAKI Koichi Kyorin University, 医学部, 准教授 (80272540)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Kumiko 杏林大学, 医学部, 実験助手 (60398592)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アミノ酸トランスポーター / LAT / 血管平滑筋 / 頚動脈 / ApoE欠損マウス |
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| Research Abstract |
LAT1, a transporter providing essential amino acids into the cells, is expressed in the rat aortic smooth muscle cells (RASMC), and also in the carotid artery. LAT1 is necessary for the growth and survival of RASMC. Animal experiments showed that LAT1 plays an important role in the neointima formation after vascular injury in the carotid and femoral artery. Furthermore, we are investigating the role of LAT1 in the development of atherosclerosis and in the function of blood-brain barrier.
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