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2008 Fiscal Year Final Research Report

Pathogenesis of malignant pleural mesothelioma

Research Project

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Project/Area Number 19590547
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionChiba University

Principal Investigator

廣島 健三  Chiba University, 大学院・医学研究院, 准教授 (80218833)

Co-Investigator(Kenkyū-buntansha) NAKATANI Yukio  千葉大学, 大学院・医学研究院, 教授 (20137037)
TOMONAGA Tsuyoshi  医薬基盤研究所, 基盤的研究部プロテオームリサーチプロジェクト, プロジェクトリーダー (80227644)
TANIZAWA Tohru  千葉大学, 医学部・付属病院, 准教授 (00227232)
SUZUKI Makoto  千葉大学, 大学院・医学研究院, 講師 (80312940)
OIDE Takashi  千葉大学, 大学院・医学研究院, 助教 (00422246)
YONEMORI Yoko  千葉大学, 大学院・医学研究院, 助教 (10422247)
Co-Investigator(Renkei-kenkyūsha) IYODA Akira  北里大学, 医学部, 講師 (10302548)
Project Period (FY) 2007 – 2008
Keywords中皮腫 / 壁側胸膜 / 臓側胸膜 / mesothelioma in situ / epithelial membrane antigen / (EMA) / GLUT-1 / 2時元電気泳動 / 2-D DIGE
Research Abstract

早期の胸膜中皮腫は腫瘍細胞が胸膜表面に一層性あるいは乳頭状に認められ, 壁側胸膜と臓側胸膜の両方に腫瘍が進展している. 中皮腫は早期に腫瘍を摘出しても過半数は3年以内に死亡する. 5年以上生存した症例はいずれも上皮型であり, desmoplasiaや壊死を認めず, 腫瘍細胞の細胞増殖能は低く, 癌抑制遺伝子のプロモーター領域のメチル化の頻度は低い. このような特徴をもつ中皮腫が胸膜肺全摘術の適応になる.

  • Research Products

    (15 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (5 results)

  • [Journal Article] Malignant pleural mesothelioma : A clinicopathological study of sixteen extrapleural pneumonectomy cases with special reference to early stage features2009

    • Author(s)
      Hiroshima K, Yusa T, Kameya T, Ito I, Kaneko K, Kadoyama C, Kishi H, Saitoh Y, Ozaki D, Itami M, Iwata T, Iyoda A, Kawai T, Yoshino I, Nakatani Y.
    • Journal Title

      Pathol Int. (in press)

    • Peer Reviewed
  • [Journal Article] Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung2008

    • Author(s)
      Amin RM, Hiroshima K, Miyagi Y, Kokubo T, Hoshi K, Fujisawa T, Nakatani Y
    • Journal Title

      Pathol Int. 58

      Pages: 38-44

    • Peer Reviewed
  • [Journal Article] Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis2008

    • Author(s)
      Suzuki M, Mohamed S, Nakajima T, Kubo R, Tian L, Fujiwara T, Suzuki H, Nagato K, Chiyo M, Motohashi S, Yasufuku K, Iyoda A, Yoshida S, Sekine Y, Shibuya K, Hiroshima K, Nakatani Y, Yoshino I, Fujisawa T.
    • Journal Title

      Int J Oncol. 33

      Pages: 113-119

    • Peer Reviewed
  • [Journal Article] 石綿曝露の病理学的評価2008

    • Author(s)
      廣島健三, 由佐俊和, 篠原也寸志
    • Journal Title

      肺癌 49

      Pages: 48-57

    • Peer Reviewed
  • [Journal Article] 悪性中皮腫の病理診断2008

    • Author(s)
      廣島健三
    • Journal Title

      日本臨床 66(Suppl 6)

      Pages: 374-378

  • [Presentation] 中皮腫の克服を目指して基礎と臨床の最前線肉眼的に腫瘤を認めない早期胸膜中皮腫の検討2008

    • Author(s)
      廣島健三, 由佐俊和, 柴崎正巳, 兼子耕, 岸宏久, 斉藤忠, 伊藤以知郎, 山川久美, 前澤直樹, 伊丹真紀子, 尾崎大介, 亀井敏昭, 吉野一郎, 中谷行雄
    • Organizer
      第47回日本臨床細胞学会総会(秋期大会)
    • Place of Presentation
      東京
    • Year and Date
      2008-11-15
  • [Presentation] Microscopic malignant pleural mesothelioma2008

    • Author(s)
      Hiroshima K, Yusa T, Tanizawa T, Yonemori Y, Oide T, Kameya T, Ito I, Kaneko K, Kishi H, Ozaki D, Itami M, Kawai T, Nakatani Y.
    • Organizer
      27th International Congress of the International Academy of Pathology
    • Place of Presentation
      ギリシア, アテネ
    • Year and Date
      2008-10-16
  • [Presentation] Early detection of malignant pleural mesothelioma2008

    • Author(s)
      Hiroshima K, Yusa T, Kameya T, Kadoyama C, Saitoh Y, Iwata T, Tada Y, Shimada H, Tagawa M, Nakatani Y.
    • Organizer
      9th International Mesothelioma Interest Group Conference
    • Place of Presentation
      オランダ, アムステルダム
    • Year and Date
      2008-09-25
  • [Presentation] Pathological study of malignant pleural mesothelioma resected with extrapleural pneumonectomy2007

    • Author(s)
      Hiroshima K, Yusa T, Kameya T, Ito I, Kawai T, Kaneko K, Kadoyama C, Kishi H, Fujisawa T, Nakatani Y.
    • Organizer
      12th World Conference on Lung Cancer
    • Place of Presentation
      韓国, ソウル
    • Year and Date
      2007-09-03
  • [Presentation] Pathological study of malignant pleural mesothelioma resected with extrapleural pneumonectomy2007

    • Author(s)
      Hiroshima K, Yusa T, Kaneko K, Kadoyama C, Kishi H, Itami M, Fujisawa T, Nakatani Y.
    • Organizer
      United States and Canadian Academy of Pathology Annual Meeting 2007
    • Place of Presentation
      アメリカ合衆国, サンディエゴ
    • Year and Date
      2007-03-27
  • [Book] Pathological distinction of pulmonary large cell carcinoma from small-cell lung carcinoma using immunohistochemistry. General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma. In : Method of cancer diagnosis, therapy and prognosis. Hayat MA ed., Vol. 22008

    • Author(s)
      Hiroshima K
    • Total Pages
      349-361
    • Publisher
      Springer
  • [Book] 早期中皮腫の特徴. 画像と病理像から学ぶ中皮腫アトラス2008

    • Author(s)
      廣島健三, 由佐俊和. 井内康輝監修
    • Total Pages
      271-277
    • Publisher
      篠原出版新社
  • [Book] 悪性胸膜中皮腫の早期病変MOOK「肺癌の臨床」(加藤治文, 西條長宏, 福岡正博, 小林紘一, 海老原善郎, 井内康輝, 早川和重監修)2008

    • Author(s)
      廣島健三
    • Total Pages
      337-343
    • Publisher
      篠原出版新社
  • [Book] アスベストと中皮腫. 石綿関連疾患の病理. 石綿関連の非腫瘍性疾患の病理(森永謙二編)2007

    • Author(s)
      廣島健三. 亀井敏昭, 石川雄一, 三浦溥太郎, 井内康輝
    • Total Pages
      193-198
    • Publisher
      篠原出版新社
  • [Book] 呼吸器common diseaseの診療. 肺癌のすべて. 前癌病変2007

    • Author(s)
      廣島健三. 工藤翔二監修
    • Total Pages
      68-73
    • Publisher
      文光堂

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Published: 2010-06-10   Modified: 2016-04-21  

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