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2008 Fiscal Year Final Research Report

Molecular diagnosis by evaluating histone methylation

Research Project

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Project/Area Number 19590566
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionSapporo Medical University

Principal Investigator

ADACHI Masaaki  Sapporo Medical University, 医学部, 准教授 (70240926)

Co-Investigator(Kenkyū-buntansha) YASUI Hiroshi  札幌医科大学, 医学部, 研究員 (40448593)
IMAI Imai  札幌医科大学, 学長 (60117603)
Project Period (FY) 2007 – 2008
Keywordsヒストンメチル化 / 小胞体ストレス / 酸化ストレス / クロマチン構造
Research Abstract

ヒストンメチレーションがストレス状態によって変化しうることが明らかとなった。フローサイトメトリーを用いたリンパ球の解析から、ホストのストレス状態を把握できる可能性があり、診断法開発への基盤となる成果が得られたといえる。

  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Preventing oxidative stress: A new role for XBP12009

    • Author(s)
      Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K and Shinomura Y
    • Journal Title

      Cell Death Diff (in press)

    • Peer Reviewed
  • [Journal Article] A novel combination therapy of arsenic trioxide with parthenolide against pancreatic cancer Cells2009

    • Author(s)
      Wang W, Adachi M, Zhou J, and Zhu D
    • Journal Title

      Pancreas (in press)

    • Peer Reviewed
  • [Journal Article] SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK2009

    • Author(s)
      Okawa Y, Hideshima T, Steed P, Vallet S, Hall S, Huang K, Rice J, Barabasz A, Foley B, Ikeda H, Raje N, Kiziltepe T, Yasui H, Enatsu S, Anderson KC
    • Journal Title

      Blood 113

      Pages: 846-855

    • Peer Reviewed
  • [Journal Article] Fatty acid synthase is a novel therapeutic target in multiple myeloma2008

    • Author(s)
      Okawa Y, Hideshima T, Ikeda H, Raje N, Vallet S, Kiziltepe T, Yasui H, Enatsu S, Pozzi S, Breitkreutz I, Cirstea D, Santo L, Richardson P, Anderson KC.
    • Journal Title

      Br. J. Haematol 141

      Pages: 659-671

    • Peer Reviewed
  • [Journal Article] Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma2007

    • Author(s)
      Neri P, Tassone P, Shammas M, Yasui H, Schipani E, Batchu RB, Blotta S, Prabhala R, Catley L, Hamasaki M, Hideshima T, Chauhan D, Jacob GS, Picker D, Venuta S, Anderson KC, Munshi NC
    • Journal Title

      Leukemia 21

      Pages: 2519-2526

    • Peer Reviewed
  • [Journal Article] Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells2007

    • Author(s)
      Hideshima T, Catley L, Raje N, Chauhan D, Podar K, Mitsiades C, Tai YT, Vallet S, Kiziltepe T, Ocio E, Ikeda H, Okawa Y, Hideshima H, Munshi NC, Yasui H, Richardson PG, Anderson KC
    • Journal Title

      Br J Haematol 138

      Pages: 783-791

    • Peer Reviewed
  • [Journal Article] MILN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts2007

    • Author(s)
      Vallet S, Raje N, Ishitsuka K, Hideshima T, Podar K, Chhetri S, Pozzi S, Breitkreutz I, Kiziltepe T, Yasui H, Ocio EM, Shiraishi N, Jin J, Okawa Y, Ikeda H, Mukherjee S, Vaghela N, Cirstea D, Ladetto M, Boccadoro M, Anderson KC
    • Journal Title

      Blood 110

      Pages: 3744-3752

    • Peer Reviewed
  • [Journal Article] 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells2007

    • Author(s)
      Kiziltepe T, Hideshima T, Catley L, Raje N, Yasui H, Shiraishi N, Okawa Y, Ikeda H, Vallet S, Pozzi S, Ishitsuka K, Ocio EM, Chauhan D, Anderson KC
    • Journal Title

      Mol Cancer Ther 6

      Pages: 1718-1727

    • Peer Reviewed
  • [Journal Article] JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells2007

    • Author(s)
      Kiziltepe T, Hideshima T, Ishitsuka K, Ocio EM, Raje N, Catley L, Li CQ, Trudel LJ, Yasui H, Vallet S, Kutok JL, Chauhan D, Mitsiades CS, Saavedra JE, Wogan GN, Keefer LK, Shami PJ, Anderson KC
    • Journal Title

      Blood 110

      Pages: 709-718

    • Peer Reviewed
  • [Journal Article] Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma2007

    • Author(s)
      Sukhdeo K, Mani M, Zhang Y, Dutta J, Yasui H, Roon e H, Tai YT, Mitsiades C, Anderson KC, Carrasco DR
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 7516-7521

    • Peer Reviewed
  • [Journal Article] Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma2007

    • Author(s)
      Podar K, Raab MS, Tonon G, Sattler M, Barila D, Zhang J, Tai YT, Yasui H, Raje N, DePinho RA, Hideshima T, Chauhan D, Anderson KC
    • Journal Title

      Cancer Res 67

      Pages: 1680-1688

    • Peer Reviewed
  • [Journal Article] Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells2007

    • Author(s)
      Adachi M, Sakamoto H, Kawamura R, Wang W, Imai K, Shinomura Y
    • Journal Title

      Histol Histopathol 22

      Pages: 437-442

    • Peer Reviewed
  • [Presentation] XBP1の新しい機能 : 酸化ストレス応答への関与2008

    • Author(s)
      安達正晃、劉耀華、趙世光、Koong Albert, Rando Thomas, Dan Ruo, 今井浩三、篠村泰久
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
  • [Presentation] Preventing oxidative stress : A new role for XBP1 and its candidate as a molecular target for cancer2008

    • Author(s)
      Adachi M, Liu Y, Zhao S, Hareyama M, Koong A, Imai K and Shinomura Y
    • Organizer
      The 6^<th> International Symposium on cancer research and therapy
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-22
  • [Presentation]2008

    • Author(s)
      安達正晃、劉耀華、Koong Albert, 今井浩三、篠村泰久
    • Organizer
      第17回日本癌病態治療研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-26
  • [Presentation] IL-2シグナルと小胞体ストレスシグナル2007

    • Author(s)
      安達正晃, 劉耀華、今井浩三、篠村泰久
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
  • [Presentation] 内在性ホルモンを利用した新たな放射線感受性亢進療法の開発2007

    • Author(s)
      安達正晃、今井浩三、晴山雅人、篠村恭久
    • Organizer
      第16回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-28
  • [Book] 基質依存性増殖/アノイキス(Anoikis)改訂培養細胞実験ハンドブック2008

    • Author(s)
      安達正晃
    • Total Pages
      135-138
    • Publisher
      羊土社
  • [Book] 遺伝子治療看護のための最新医学講座第2版24巻(腫瘍の臨床)2008

    • Author(s)
      安達正晃
    • Total Pages
      215-227
    • Publisher
      中山書店

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Published: 2010-06-10   Modified: 2016-04-21  

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