Association of minerals and trace elements with bone metabolism andprognosis in hemodialysis patients

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590597
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Iwate Medical University
• Principal Investigator: ITAI Kazuyoshi Iwate Medical University, 医学部, 准教授 (10048572)
• Co-Investigator(Renkei-kenkyūsha): SAKATA Kiyomi 岩手医科大学, 医学部, 教授 (50225794) ; NAKAMURA Motoyuki 岩手医科大学, 医学部, 教授 (40172449) ; KONDA Ryuichiro 岩手医科大学, 医学部, 准教授 (10225609) ; OSAWA Masaki 岩手医科大学, 医学部, 講師 (60295970) ; TANNO Kozo 岩手医科大学, 医学部, 講師 (20327026)
• Project Period (FY): 2007 – 2008
• Keywords: 血液透析 / 血清 / 微量元素 / 腎不全

Research Abstract

透析患者の血清中微量元素濃度を測定し、健常成人の血清中微量元素濃度と比較した。透析患者で健常成人よりも高値を示した元素は、モリブデン、コバルト、マンガン、ホウ素、ストロンチウム、ヒ素、フッ素で、ルビジウムとカドミウムは男性のみが高値を示した。反対に透析患者で低値を示した元素は亜鉛、銅、セレンであった。透析患者の死亡率と関連が見られたのは銅、セレン及びホウ素であった。透析患者の骨密度は同年代の健常人に比べて低レベルにあった。

Research Products

• [Presentation] Hemodialysis patients rapidly lose their bone minerals after 60 years of age (2008)
  • Author(s): Masaki Ohsawa, Kozo Tanno, Kazuyoshi Itai, Toshiyuki Onoda, Kiyomi SakataKaren Kato, Yosuke Fujishima, RyuichiKonda, Tomoaki Fujioka, Fumitoshi Yamauchi, Mikihiko Fujishima, Akira Okayama
  • Organizer: ASBMR 30th Annual Meeting
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-16
• [Presentation] Serum ionic fluoride levels among hemodialysis patients are positively associated with levels of serum ph osphate and intact PTH (2008)
  • Author(s): Kozo Tanno, Masaki Ohsawa, Kazuyoshi Itai, Toshiyuki Onoda, Kiyomi Sakata, Karen Kato, Yosuke Fujishima, Ryuichiro Konda, Tomoaki Fujioka, Fumitoshi Yamauchi, Mikihiko Fujishima, Akira Okayama
  • Organizer: 30th ASBMR Annual Meeting
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-16
• [Presentation] Elevated serum ionic fluoride levels in post-menopausal women is due to the enhanced release of fluoride from bone (2008)
  • Author(s): Kazuyoshi Itai, Masaki Ohsawa, Kozo Tanno, Toshiyuki Onoda, Tamotsu Sato, Toru Kuribayashi, Kiyomi Saka, Akira Okayama
  • Organizer: 30th ASBMR Annual Meeting
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-16
• [Presentation] 透析患者の血清中微量元素濃度について (2008)
  • Author(s): 板井一好、大澤正樹、丹野高三、加藤香廉、藤島洋介、遠藤重厚、岡山明、藤岡知昭
  • Organizer: 第19回日本微量元素学会
  • Place of Presentation: 東京都
  • Year and Date: 20080700