Epidemiological study on the interaction between environmental factors and genetic factors in the development of atopic eczema

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Fukuoka University
• Principal Investigator: MIYAKE Yoshihiro Fukuoka University, 医学部, 准教授 (50330246)
• Co-Investigator(Kenkyū-buntansha): TANAKA Keiko 福岡大学, 医学部, 助教 (40341432) ; KIYOHARA Chikako 九州大学, 大学院・医学研究院, 講師 (00169963) ; SASAKI Satoshi 東京大学, 大学院・医学系研究科, 教授 (70275121)
• Project Period (FY): 2007 – 2008
• Keywords: 分子遺伝疫学 / 前向きコホート研究

Research Abstract

アレルギー疾患のリスク要因の解明を目的とした出生前開始二世代継続前向きコホート研究である「九州・沖縄母子保健研究」を実施した。平成19年度に九州・沖縄在住の妊婦1758名がベースライン調査に参加した。平成20年度末まで、順次、出生時追跡調査、4ヶ月時追跡調査、満1歳時追跡調査を開始した。概ね1500組の母子が追跡調査に参加している。遺伝要因については、初歩的調査として、福岡市3歳児約400名より遺伝情報を得て、アトピー性皮膚炎の症例対照研究を設定した。統計学的に有意な関連性が認められたのはADAM33rs2853209 SNP(オッズ比=1.82, 95%信頼区間=1.00-3.36)のみであった。「大阪母子保健研究」及び「琉球小児健康調査」のデータベースを用いて、計15編の英文原著論文を公表した。

Research Products

• [Journal Article] ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese Children. (2009)
  • Author(s): Matsusue A, Kiyohara C, Tanaka K, Sasaki S, Miyake Y.
  • Journal Title: Clin Biochem. 42 Pages: 477-483
  • Peer Reviewed
• [Journal Article] Monetary diet cost is associated with not only favorable but also unfavorable aspects of diet in pregnant Japanese women : the Osaka Maternal and Child Health Study. (2009)
  • Author(s): Murakami K, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y, the Osaka Maternal and Child Health Study Group.
  • Journal Title: Environmental Health Insights. 2 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Breastfeeding and atopic eczema in Japanese infants : The Osaka Maternal and Child Health Study. (2009)
  • Author(s): Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Ohya Y, Fukushima W, Yokoyama T, Hirota Y.
  • Journal Title: Pediatr Allergy Immunol. 20 Pages: 234-241
  • Peer Reviewed
• [Journal Article] Education, but not occupation or household income, is positively related to favorable dietary intake patterns in pregnant Japanese women : the Osaka Maternal and Child Health Study. (2009)
  • Author(s): Murakami K, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y, The Osaka Maternal and Child Health Study Group.
  • Journal Title: Nutr Res. 29 Pages: 164-172
  • Peer Reviewed
• [Journal Article] Relationship between dietary fat and fish intake and the prevalence of atopic eczema in pregnant Japanese females : baseline data from the Osaka Maternal and Child health Study. (2008)
  • Author(s): Miyake Y, Sasaki S, Tanaka K, Ohya Y, Matsunaga I, Yoshida T, Hirota Y, Oda H.
  • Journal Title: Asia Pac J Clin Nutr. 17 Pages: 612-619
  • Peer Reviewed
• [Journal Article] Maternal smoking and environmental tobacco smoke exposure and the risk of allergic diseases in Japanese infants : the Osaka Maternal and Child Health Study. (2008)
  • Author(s): Tanaka K, Miyake Y, Sasaki S, Ohya Y, Hirota Y, The Osaka Maternal and Child Health Study Group.
  • Journal Title: J Asthma. 45 Pages: 833-838
  • Peer Reviewed
• [Journal Article] Fatty acid intake and asthma symptoms in Japanese children : The Ryukyus Child Health Study. (2008)
  • Author(s): Miyake Y, Sasaki S, Arakawa M, Tanaka K, Murakami K, Ohya Y.
  • Journal Title: Clin Exp Allergy. 38 Pages: 1644-1650
  • Peer Reviewed
• [Journal Article] Dental caries and allergic disorders in Japanese Children : the Ryukyus Child Health Study. (2008)
  • Author(s): Tanaka K, Miyake Y, Arakawa M, Sasaki S, Ohya Y.
  • Journal Title: J Asthma. 45 Pages: 795-799
  • Peer Reviewed
• [Journal Article] Beverage consumption and the prevalence of tooth loss in Japanese women : the Osaka Maternal and Child Health Study. (2008)
  • Author(s): Tanaka K, Miyake Y, Sasaki S, Ohya Y, Matsunaga I, Yoshida T, Hirota Y, Oda H, The Osaka Maternal and Child Health Study Group.
  • Journal Title: Fukuoka Igaku Zasshi. 99 Pages: 80-89
  • Peer Reviewed
• [Journal Article] Dietary glycemic index and load and the risk of postpartum depression in Japan : The Osaka Maternal and Child Health Study. (2008)
  • Author(s): Murakami K, Miyake Y, Sasaki S, Tanaka K, Yokoyama T, Ohya Y, Fukushima W, Kiyohara C, Hirota Y, The Osaka Maternal and Child Health Study Group.
  • Journal Title: J Affect Disord. 110 Pages: 174-179
  • Peer Reviewed
• [Journal Article] Breastfeeding and the risk of wheeze and asthma in Japanese infants : The Osaka Maternal and Child Health Study. (2008)
  • Author(s): Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Ohya Y, Fukushima W, Yokoyama T, Hirota Y.
  • Journal Title: Pediatr Allergy Immunol. 19 Pages: 490-496
  • Peer Reviewed
• [Journal Article] Tuberculin reactivity and allergic disorders in schoolchildren, Okinawa, Japan. (2008)
  • Author(s): Miyake Y, Arakawa M, Tanaka K, Sasaki S, Ohya Y.
  • Journal Title: Clin Exp Allergy. 38 Pages: 486-492
  • Peer Reviewed
• [Journal Article] Ambient formaldehyde levels and allergic disorders among Japanese pregnant women : baseline data from the Osaka Maternal and Child Health Study. (2008)
  • Author(s): Matsunaga I, Miyake Y, Yoshida T, Miyamoto S, Ohya Y, Sasaki S, Tanaka K, Oda H, Ishiko O, Hirota Y, The Osaka Maternal and Child Health Study Group.
  • Journal Title: Ann Epidemiol. 18 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Relationship between intake of vegetables, fruit, and grains and the prevalence of tooth loss in Japanese women. (2007)
  • Author(s): Tanaka K, Miyake Y, Sasaki S, Ohya Y, Matsunaga I, Yoshida T, Hirota , Oda H, The Osaka Maternal and Child Health Study Group.
  • Journal Title: J Nutr Sci Vitaminol. 53 Pages: 522-528
  • Peer Reviewed
• [Journal Article] Prevalence of asthma and wheeze in relation to passive smoking in Japanese children. (2007)
  • Author(s): Tanaka K, Miyake Y, Arakawa M, Sasaki S, Ohya Y.
  • Journal Title: Ann Epidemiol. 17 Pages: 1004-1010
  • Peer Reviewed
• [Journal Article] Cross-sectional study of allergic disorders associated with breastfeeding in Japan : The Ryukyus Child Helath Study. (2007)
  • Author(s): Miyake Y, Arakawa M, Tanaka K, Sasaki S, Ohya Y.
  • Journal Title: Pediatr Allergy Immunol. 18 Pages: 433-440
  • Peer Reviewed
• [Journal Article] Home environment and suspected atopic eczema in Japanese infants : The Osaka Maternal and Child Health Study. (2007)
  • Author(s): Miyake Y, Ohya Y, Tanaka K, Yokoyama T, Sasaki S, Fukushima W, Ohfuji S, Saito K, Kiyohara C, Hirota Y, The Osaka Maternal and Child Health Study Group.
  • Journal Title: Pediatr Allergy Immunol. 18 Pages: 425-432
  • Peer Reviewed
• [Journal Article] Fish and fat intake and prevalence of allergic rhinnitis in Japanese females : the Osaka Maternal and Child Helath Study. (2007)
  • Author(s): Miyake Y, Sasaki S, Tanaka K, Ohya Y, Miyamoto S, Matsunaga I, Yoshida T, Hirota Y, Oda H, The Osaka Maternal and Child Health Study Group.
  • Journal Title: J Am Cool Nutr. 26 Pages: 279-287
  • Peer Reviewed
• [Journal Article] Maternal fat consumption during Pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months : The Osaka Maternal and Child Health Study.
  • Author(s): Miyake Y, Sasaki S, Tanaka K, Ohfuji S, Hirota Y.
  • Journal Title: Thorax (in press) Pages: 0
  • Peer Reviewed
• [Journal Article] Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3-4 months : The Osaka Maternal and Child Health Study.
  • Author(s): Saito K, Yokoyama T, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y.
  • Journal Title: Pediatr Allergy Immunol. (in press) Pages: 0
  • Peer Reviewed
• [Journal Article] Sibship size and prevalence of allergic disorders in Japan : The Ryukyus Child Health Study.
  • Author(s): Ohfuji S, Miyake Y, Arakawa M, Tanaka K, Sasaki S.
  • Journal Title: Pediatr Allergy Immunol. (in press) Pages: 0
  • Peer Reviewed
• [Presentation] 妊娠時における自宅と幹線道路との距離と子供のアレルギー発症との関連 (2008)
  • Author(s): 三宅吉博、田中景子、藤原裕司、三谷泰浩、池見洋明、佐々木敏、大矢幸弘、廣田良夫
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-12
• [Presentation] 脂肪酸摂取と喘息有症率との関連 : 琉球小児健康調査 (2008)
  • Author(s): 三宅吉博、佐々木敏、荒川雅志、田中景子、村上健太郎、大矢幸弘
  • Organizer: 第18回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-25
• [Presentation] 母乳と喘息、喘息のリスク : 大阪母子保健研究 (2007)
  • Author(s): 三宅吉博、田中景子、佐々木敏、清原千香子、大矢幸弘、福島若葉、横山徹爾、廣田良夫
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-11-01
• [Presentation] ツベルクリン反応とアレルギー疾患との関連 : 琉球小児健康調査 (2007)
  • Author(s): 三宅吉博、荒川雅志、田中景子、大矢幸弘、佐々木敏
  • Organizer: 第19回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-06-10