2008 Fiscal Year Final Research Report
Cytogenetic study on dioxin damage in defoliant-heavily sprayed area in Vietnam
| Project/Area Number |
19590614
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
佐藤 裕子 Research Institute, International Medical Center of Japan (10137713)
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| Project Period (FY) |
2007 – 2008
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| Keywords | ダイオキシン / ベトナム戦争 / 枯れ葉剤 / 姉妹染色体交換指数 / 母乳 |
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| Research Abstract |
ベトナム戦争時に枯葉剤が濃厚に散布された南ベトナムの一地区の授乳期婦人から母乳と末梢血を採取して、母乳中のダイオキシン値と末梢血の姉妹染色体分体交換(SCE)指数を測定したところ、対象地区の授乳期婦人のそれに比べ、
(1)母乳中のダイオキシン値は3~4倍高値であり、
(2)SCE indexは有意に高いこと、また、
(3)母乳中のダイオキシン値とSCE indexのlog値を取ったところ、相関することが判った。
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[Journal Article] Relation between dioxins levels in human breast milk samples and sce values among lactating females in a defoliants -sprayed area in vietnam.2008
Author(s)
Horikawa H, Suzuki H, Naganuma R, Tawara K, Nishijo M, Nakagawa H, Hung NN, Thom LTH, Dung PT , Nhu DD, Van PT, Binh NT, Watanabe T, Kido T, Sato Y
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Journal Title
Organohalogen Compounds 70
Pages: 646-9
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[Journal Article] Green Tea Epigalocatechin gallate (EGCG) Exhibits anticancer effect in Human Pancreatic Carcinoma Cells via Inhibition of both Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor
Author(s)
Vu HA, Beppu Y, Hoang Chi HT, Sasaki K, Yamamoto H, Xinh PT, Tanii T, Hara Y, Watanabe T, Sato Y, Ohdomari I
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Journal Title
Pancreaticus in press
Pages: 0
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[Presentation] Imatinib-resistant Ph+ leukemia including BCR-ABL/T315I both in vitro and in vivo.2008
Author(s)
Shiotsu Y, Kiyoi H, Tanizaki R, Minami Y, Abe A, Ishikawa Y, Ishii K, Shimizu M, Kanda Y, Sato Y, Akinaga S1, Cortes J, Naoe T
Organizer
The 50th Annual Meeting of American Society of Hematology, in San Francisco
Place of Presentation
San Francisco
Year and Date
20081205-09
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[Presentation] Relation between dioxins levels in human breast milk samples and sce values among lactating females in a defoliants -sprayed area in vietnam.2008
Author(s)
Horikawa H, Suzuki H, Naganuma R, Tawara K, Nishijo M, Nakagawa H, Hung NN, Thom LTH, Dung PT , Nhu DD, Van PT, Binh NT, Watanabe T, Kido T, and Sato Y
Organizer
Dioxin 2008, the 28th International Symposium on Halogenated Persistent Organic Pollutants
Place of Presentation
Birmngham (UK)
Year and Date
20080816-22
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