Community-based molecular prevention study for diabetic nephropathy

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19590617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: SAKANE Naoki Department of Clinical Research, National Hospital Organization Kyoto Medical Center, 京都医療センター臨床研究センター, 研究室長 (40335443)
• Project Period (FY): 2007 – 2010
• Keywords: 糖尿病 / 腎症 / 慢性腎臓病 / 遺伝子多型 / 介入

Research Abstract

糖尿病性腎症の発症には遺伝、食事及び炎症が複雑に関与する。そこで、地域を基盤とした腎症の発症に及ぼす要因を明らかとし、介入方法を確立することを目的としている。

Research Products

• [Journal Article] Adiponectin and lipoprotein particle size (2010)
  • Author(s): Tsuzaki K, Kotani K, Fujiwara S, Sakane N
  • Journal Title: Diabetes Care 33 Pages: el1
  • Peer Reviewed
• [Journal Article] S447X polymorphism in the lipoprotein lipase gene and the adiponectin level in the general population : results from the Mima study (2009)
  • Author(s): Fujiwara S, Kotani K, Sano Y, Matsuoka Y, Tauzaki K, Domichi M, Kajii E, Sakane N
  • Journal Title: 16 Pages: 188-193
  • Peer Reviewed
• [Journal Article] The UCP2-866 A/A genotype is associated with low density lipoprotein particle sizes in the general population (2008)
  • Author(s): Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Takahashi K, Sakane N.
  • Journal Title: Med Sci Monit 14 Pages: CR107-111
  • Peer Reviewed
• [Journal Article] The common-55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population (2008)
  • Author(s): Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Sakane N.
  • Journal Title: Metabolism 57 Pages: 410-415
  • Peer Reviewed
• [Journal Article] Lifestyles and oxidative stress in type 2 diabetic patients (2008)
  • Author(s): Kotani K, Sakane N, Tsuzaki K, Matsuoka Y, Sano Y, Hamada T, Yamada K.
  • Journal Title: Scand J Clin Lab Invest8 8 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Oxidative stress, inflammation, and atherosclerotic changes in retinal arteries in the Japanese population ; results from the Mima study (2008)
  • Author(s): Sakane N, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Matsuoka Y, Hamada T, Saiga K, Kotani K.
  • Journal Title: Endocr J. 55 Pages: 485-488
  • Peer Reviewed
• [Journal Article] The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population (2008)
  • Author(s): Kotani K, Tsuzaki K, Sano Y, Maekawa M, Fujiwara S, Hamada T, Sakane N
  • Journal Title: Clin Chem Lab Med. 46 Pages: 1431-1437
  • Peer Reviewed
• [Journal Article] The angiotensin II type 2 receptor gene polymorphism and body mass index in healthy Japanese women (2007)
  • Author(s): Kotani K, Sakane N, Saiga K, Tsuzaki K, Sano Y, Mu H, Kurozawa Y
  • Journal Title: Ann Clin Biochem. 44 Pages: 83-85
  • Peer Reviewed
• [Journal Article] Sweetened canned coffee cessation intervention for subjects with type 2 diabetes mellitus : a preliminary study (2007)
  • Author(s): Kotani K, Kurozawa Y, Sakane N, Adachi S, Ishimaru Y
  • Journal Title: Fam Med. 39 Pages: 83-84
  • Peer Reviewed
• [Journal Article] Clustered components of the metabolic syndrome and platelet counts in Japanese females (2007)
  • Author(s): Kotani K, Sakane N, Saiga K, Mu H, Kurozawa Y
  • Journal Title: Clin Chem Lab Med. 45 Pages: 376-379
  • Peer Reviewed
• [Journal Article] The peroxisome proliferator-activated receptor gamma2 gene Pro12Ala polymorphism and serum C-reactive protein in general Japanese population (2007)
  • Author(s): Kotani K, Saiga K, Kurozawa Y, Sakane N, Sano Y, Tabata M
  • Journal Title: Clin Chim Acta. 383 Pages: 178-179
  • Peer Reviewed
• [Journal Article] Serum adiponectin levels and lifestyle factors in Japanese men (2007)
  • Author(s): Kotani K, Sakane N, Saiga K, Kato M, Ishida K, Kato Y, Kurozawa Y
  • Journal Title: Heart Vessels. 22 Pages: 291-296
  • Peer Reviewed
• [Journal Article] Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene with small dense low-density lipoprotein in the general population. (2007)
  • Author(s): Hamada T, Kotani K, Tsuzaki K, Sano Y, Murata T, Tabata M, Sato S, Sakane N
  • Journal Title: Metabolism. 56 Pages: 1345-1349
  • Peer Reviewed
• [Journal Article] Lifestyle-related determinants and serum adiponectin concentrations in a general population of Japanese females (2007)
  • Author(s): Kotani K, Sakane N, Saiga K, Sano Y, Kurozawa Y
  • Journal Title: Arch Med Res. 38 Pages: 887-890
  • Peer Reviewed
• [Journal Article] The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population : the Mima study (2007)
  • Author(s): Tsuzaki K, Kotani K, Fujiwara S, Sano Y, Matsuoka Y, Domichi M, Hamada T, Shimatsu A, Sakane N
  • Journal Title: Metabolism. 56 Pages: 1689-1693
  • Peer Reviewed
• [Journal Article] The uncoupling protein-1 gene-3826A/G polymorphism and hypertension in Japanese subjects (2007)
  • Author(s): Kotani K, Sakane N, Saiga K, Tsuzaki K, Shimohiro H, Tabata M, Kurozawa Y
  • Journal Title: Clin Chem Lab Med. 45 Pages: 1186-1189
  • Peer Reviewed
• [Journal Article] Adiponectin I164T gene polymorphism and the obesity-related effects on the Japanese female population (2007)
  • Author(s): Kotani K, Saiga K, Kurozawa Y, Sakane N, Tsuzaki K, Hamada T
  • Journal Title: Clin Chim Acta. 384 Pages: 182-183
  • Peer Reviewed
• [Presentation] 時計遺伝子多型と脂質プロファイルとの関連性 徳島県美馬研究から (2009)
  • Author(s): 津崎ここ, ろ, 小谷和彦, 佐野喜子, 松岡幸代, 同道正行, 兼田淳子, 石井麗子, 藤原真治, 坂根直樹
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: 浜松
  • Year and Date: 20091019-20091020
• [Presentation] エクオール産生がBMI、レプチン、高感度CRPに与える影響 徳島県美馬研究から (2008)
  • Author(s): 坂根直樹, 小谷和彦, 佐野喜子, 松岡幸代, 津崎ここ, ろ
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 20081017-20081018
• [Presentation] 慢性腎臓病におよぼすACE遺伝子多型と肥満の影響 徳島県美馬研究から (2008)
  • Author(s): 小谷和彦, 津崎ここ, ろ, 佐野喜子, 松岡幸代, 同道正行, 兼田淳子, 坂根直樹
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 20081017-20081018
• [Presentation] 地域を基盤とした糖尿病による腎不全予防の取り組み MIMA Study (2007)
  • Author(s): 藤原真治, 坂根直樹, 佐野喜子, 小谷和彦
  • Organizer: 第66回日本公衆衛生学会総会
  • Place of Presentation: 松山
  • Year and Date: 2007-10-25