Community-based molecular preventive study on diabetic nephropathy

2010 Fiscal Year Final Research Report

• Project/Area Number: 19590617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: SAKANE Naoki Department of Clinical Research, National Hospital Organization Kyoto Medical Center, 臨床研究企画運営部, 研究室長(予防医学) (40335443)
• Co-Investigator(Kenkyū-buntansha): SANO Yoshiko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (20399603)
• Project Period (FY): 2007 – 2010
• Keywords: 糖尿病 / 腎症 / 慢性腎臓病 / 遺伝子多型 / 介入

Research Abstract

The prevalence of chronic kidney disease (CKD) was 26.9% in the model community and higher than average (18.7%) for Japanese. The body mass index was associated with estimated GFR independent of age, gender, and ACE polymorphism. Several polymorphisms such as beta3-aderenoceptor were associated with the production of small dense LDL, which shows a high prevalence in diabetic nephropathy. A dietary salt reduction program using family and community support significantly decreased the blood pressure and urine albuminurea. These findings suggest that the early detection and prevention of diabetic nephropathy is important.

Research Products

• [Journal Article] Dietary salt reduction in rural patients with albuminurea using family and community support : the Mima study. (2010)
  • Author(s): Fujiwara S, Kotani K, Brantley PJ, Tsuzaki K, Matsuoka Y, Domichi M, Sano Y, Kajii E, Sakane N.
  • Journal Title: Asia Pac Fam Med 9巻 Pages: 6
  • Peer Reviewed
• [Journal Article] The association of the Clock 3111 T/C SNP with lipids and lipoproteins including small dense low-density lipoprotein : results from the Mima study. (2010)
  • Author(s): Tsuzaki K, Kotani K, Sano Y, Fujiwara S, Takahashi K, Sakane N.
  • Journal Title: BMC Med Genet 11巻 Pages: 150
  • Peer Reviewed
• [Journal Article] Adiponectin and lipoprotein particle size (2010)
  • Author(s): Tsuzaki K, Kotani K, Fujiwara S, Sakane N.
  • Journal Title: Diabetes Care 2010 33巻 Pages: e11
  • Peer Reviewed
• [Journal Article] S447X polymorphism in the lipoprotein lipase gene and the adiponectin level in the general population : results from the Mima study. (2009)
  • Author(s): Fujiwara S, Kotani K, Sano Y, Matsuoka Y, Tsuzaki K, Domichi M, Kajii E, Sakane N.
  • Journal Title: J Atheroscler Thromb 16巻 Pages: 188-193
  • Peer Reviewed
• [Journal Article] The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population (2008)
  • Author(s): Kotani K, Tsuzaki K, Sano Y, Maekawa M, Fujiwara S, Hamada T, Sakane N.
  • Journal Title: Clin Chem Lab Med 46巻 Pages: 1434-1437
  • Peer Reviewed
• [Journal Article] The UCP2-866 A/A genotype is associated with low density lipoprotein particle sizes in the general population. (2008)
  • Author(s): Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Takahashi K, Sakane N.
  • Journal Title: Med Sci Moni 14巻 Pages: CR104-111
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): Kotani K, Sakane N, Tsuzaki K, Matsuoka Y, Sano Y, Hamada T, Yamada K.
  • Journal Title: Scand L Clin Lab Inves 68巻 Pages: 516-518
  • Peer Reviewed
• [Journal Article] Oxidative stress, inflammation, and atherosclerotic changes in retinal arteries in the Japanese population ; results from the Mima study. (2008)
  • Author(s): Sakane N, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Matsuoka Y, Hamada T, Saiga K, Kotani K.
  • Journal Title: Endocr J 55巻 Pages: 485-488
  • Peer Reviewed
• [Journal Article] Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene with small dense low-density lipoprotein in the general population (2007)
  • Author(s): Hamada T, Kotani K, Tsuzaki K, Sano Y, Murata T, Tabata M, Sato S, Sakane N.
  • Journal Title: Metabolism 56巻 Pages: 1345-1349
  • Peer Reviewed
• [Journal Article] The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population : the Mima study (2007)
  • Author(s): Tsuzaki K, Kotani K, Fujiwara S, Sano Y, Matsuoka Y, Domichi M, Hamada T, Shimatsu A, Sakane N.
  • Journal Title: Metabolism 56巻 Pages: 1689-1189
• [Journal Article]
  • Author(s): Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Sakane N.
  • Journal Title: metabolism 57巻 Pages: 410-415
  • Peer Reviewed
• [Presentation] HDLの質と生活習慣との関連性について (2010)
  • Author(s): 津崎こころ, 小谷和彦, 佐野喜子, 松岡幸代, 同道正行, 兼田淳子, 坂根直樹
  • Organizer: 徳島県美馬研究から、第31回日本肥満学会
  • Year and Date: 20101001-20101002
• [Presentation] The effect of clock 3111 T/C SNP on lipid and lipoproteins including small dense low-density lipoprotein (2010)
  • Author(s): 津崎こころ, 小谷和彦, 藤原真治, 坂根直樹.
  • Organizer: the results from the Mima study、11^<th> International Congress on Obesity、Sockholm
  • Place of Presentation: Sweden
  • Year and Date: 20100711-20100715
• [Presentation] アディポネクチン及びアディポネクチン遺伝子多型がHDLプロファイルに及ぼす影響:徳島県美馬研究から (2010)
  • Author(s): 津崎こころ、佐野喜子、松岡幸代、小谷和彦、坂根直樹
  • Organizer: 徳島県美馬研究から、第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20100527-20100529
• [Presentation] 時計遺伝子多型と脂質プロファイルとの関連性 (2009)
  • Author(s): 津崎こころ, 小谷和彦, 佐野喜子, 松岡幸代, 同道正行, 兼田淳子, 石井麗子, 藤原真治, 坂根直樹
  • Organizer: 徳島県美馬研究から、第30回日本肥満学会
  • Place of Presentation: 浜松
  • Year and Date: 20091019-20091020
• [Presentation] エクオール産生がBMI、レプチン、高感度CRPに与える影響 (2008)
  • Author(s): 坂根直樹, 小谷和彦, 佐野喜子, 松岡幸代, 津崎こころ
  • Organizer: 徳島県美馬研究から、第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 20081017-20081018
• [Presentation] (2008)
  • Author(s): 小谷和彦, 津崎こころ, 佐野喜子, 松岡幸代, 同道正行, 兼田淳子, 坂根直樹
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 20081017-20081018
• [Presentation] 地域を基盤とした糖尿病による腎不全予防の取り組みMIMA Study (2007)
  • Author(s): 藤原真治, 坂根直樹, 佐野喜子, 小谷和彦
  • Organizer: 第66回日本公衆衛生学会総会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2007-10-25