2009 Fiscal Year Final Research Report
Preventive medical screening involving familial genetic testing of ATP7B in order to discover presymptomatic patients in families with Wilson's disease patients.
| Project/Area Number |
19590658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hokkaido Institute of Public Health |
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Principal Investigator |
NAKAYAMA Kenji Hokkaido Institute of Public Health, 健康科学部, 研究主査 (30442594)
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Yoshinobu 北海道立衛生研究所, 生物科学部, 主任研究員 (00414326)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Tomohiro , 北海道立衛生研究所・生物科学部, 研究職員 (10414327)
SAWADA Yukiharu 札幌医科大学, 病理学第一講座, 非常勤講師 (80111128)
SHIMIZU Norikazu 東邦大学, 医学部・第二小児科, 講師 (60256740)
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| Research Collaborator |
TAMURA Mamoru 中華人民共和国・清華大学, 医学院, 教授 (80089888)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 母子保健 / 分子予防医学 / ウイルソン病 / 銅代謝異常症 / ATP7B / 遺伝子診断 / プロテオーム解析 |
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| Research Abstract |
In these preventive medical studies, the following researches were performed : 1) the discovery of presymptomatic patients in families with Wilson's disease patients using familial genetic screening of ATP7B ; and 2) an attempt to develop novel methods for early and presymptomatic detection of Wilson's disease using both genome and proteome analyses.
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