Verification behavioral state under the anterograde amnesia caused by the involuntary intake of benzodiazepine as the date rape drug-For the prevention of the illicit use of remedy

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Asahikawa Medical College
• Principal Investigator: SHIMIZU Keiko Asahikawa Medical College, 医学部, 教授 (90312462)
• Co-Investigator(Kenkyū-buntansha): MATSUBARA Kazuo 旭川医科大学, 医学部, 教授 (20127533) ; ASARI Masaru 旭川医科大学, 医学部, 助教 (40360979)
• Project Period (FY): 2007 – 2009
• Keywords: 犯罪精神医学 / 医薬品不正利用

Research Abstract

Because the illicit use of medicine for the criminal purpose is the non-medical use, there are no available clinical data for the victim needed in the deliberation of the criminal court.
In this study, we have performed the solubility test of medical substances to beverage used in the putative abuse scene, and obtained behavioral data by the animal experiment to clarify why the victim of the date rape drug is seemingly bold after unwlling intake.

Research Products

• [Journal Article] Single nucleotide polymorphism genotyping by mini-primer allele-specific amplification with universal reporter primers for identification of degraded DNA (2009)
  • Author(s): Asari M, Watanabe S, Matsubara K, Shiono H, Shimizu K.
  • Journal Title: Anal Biochem. 386 Pages: 85-90
  • Peer Reviewed
• [Journal Article] Detection of landiolol using high-performance liquid chromatography/fluorescence : A blood esterase-sensitive ultra-short-acting β1-receptor antagonist (2009)
  • Author(s): Suno M, Kunisawa T, Yamagishi A, Ono T, Yamamoto J, Yamada T, Tasaki Y, Shimizu K, Iwasaki H, Matsubara K.
  • Journal Title: J Chromatogr B. 877 Pages: 1705-1708
  • Peer Reviewed
• [Journal Article] Hot-water-extracts of Polygonum Multiflorum Do Not Induce Any Toxicity but Elicit Limited Beneficial Effects on the Liver in Mice (2009)
  • Author(s): Noda T, Yamada T, Ohkubo T, Omura T, Ono T, Adachi T, Awaya T, Tasaki Y, Shimizu K, Matsubara K.
  • Journal Title: J Health Sci. 55(5) Pages: 720-725
  • Peer Reviewed
• [Journal Article] Differences in tissue distribution of HV2 length heteroplasmy in mitochondrial DNA between mothers and children (2008)
  • Author(s): Asari M, Azumi J, Shimizu K, Shiono H.
  • Journal Title: Forensic Sci Int. 175 Pages: 155-159
  • Peer Reviewed
• [Journal Article] Identification of four charred bodies by DNA parentage testing (2008)
  • Author(s): Azumi J, Asari M, Shimizu K, Shiono H.
  • Journal Title: Acta Crim Japon. 74(2) Pages: 51-57
  • Peer Reviewed
• [Journal Article] An autopsy case of sudden death due to acute gastric dilatation without rupture (2008)
  • Author(s): Watanabe S, Terazawa K, Asari M, Matsubara K, Shiono H, Shimizu K.
  • Journal Title: Forensic Sci Int. 180 Pages: e6-e10
  • Peer Reviewed
• [Journal Article] Date Rape Drug と健忘 (2007)
  • Author(s): 清水惠子
  • Journal Title: 旭川医科大学研究フォーラム 7(1) Pages: 2-11
  • Peer Reviewed
• [Journal Article] Utility of haplogroup determination for forensic mtDNA analysis in the Japanese population (2007)
  • Author(s): Asari M, Umetsu K. Adachi N, Azumi J, Shimizu K, Shiono H.
  • Journal Title: Legal Med. 9 Pages: 237-240
  • Peer Reviewed
• [Journal Article] 5-HT_<1A> receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus : Time dependence and regional differences (2007)
  • Author(s): Crane JW, Shimizu K, Carrasco GA, Garcia F, Jia C, Sullivan NR, D'Souza DN, Zhang Y, Van de Kar LD, Muma NA, Battaglia G.
  • Journal Title: Brain Res. 1183 Pages: 51-59
  • Peer Reviewed
• [Journal Article] Effect of length variations at nucleotide positions 303-315 in human mitochondrial DNA on transcription termination (2007)
  • Author(s): Asari M, Tan Y, Watanabe S, Shimizu K, Shiono H.
  • Journal Title: Biochem and Biophys Res Commun. 361(3) Pages: 641-644
  • Peer Reviewed
• [Presentation] Meloxicam protects against 1-methyl-4-phenyl pyridinium-induced cell death via phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells (2009)
  • Author(s): Tasaki Y, Okubo T, Yamada T, Omura T, Suno M, Iida S, Satomi M, Sakaguchi T, Asari M, Shimizu K, Matsubara K.
  • Organizer: 39^<th> Annual Meeting Society for Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 20090000
• [Presentation] 胸水および心臓血の生化学マーカーからの溺水診断 (2009)
  • Author(s): 渡邊智, 清水惠子, 片田竜一, 水尾圭祐, 西谷陽子, 松本博志
  • Organizer: 第93次日本法医学会学術全国集会. 日本法医学雑誌.63(1) : p64
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 15座位のSTR解析により低い尤度比を示した身元確認のためのDNA鑑定事例 (2009)
  • Author(s): 浅利優, 大村友博, 間瀬田千香暁, 松原和夫, 塩野寛, 清水惠子
  • Organizer: 第93次日本法医学会学術全国集会. 日本法医学雑誌.63(1) : p75
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 大腿骨頭窩の形態を用いた年齢推定法の法医実務における有用性 (2009)
  • Author(s): 山田ひろみ, 清水惠子, 浅利優, 広瀬保江, 松田都久美, 大村友博, 間瀬田千香暁, 松原和夫, 塩野寛, 坂上和弘
  • Organizer: 第93次日本法医学会学術全国集会. 日本法医学雑誌.63(1) : p95
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 現行検死制度における問題点-ある虐待事件から- (2009)
  • Author(s): 清水惠子, 浅利優, 間瀬田千香暁, 塩野寛, 郷一知, 大村友博, 松原和夫, 佐々木良, 角田康夫
  • Organizer: 第10回日本法医学会学術北日本地方集会法医学談話会第96回例会. プログラム・抄録集 2009 ; p12
  • Place of Presentation: 旭川
  • Year and Date: 20090000
• [Book] 身近な法医学 改訂3版 (2008)
  • Author(s): 塩野寛, 清水惠子
  • Total Pages: 305
  • Publisher: 南山堂
• [Book] 生命倫理への招待 改訂第3版 (2007)
  • Author(s): 塩野寛, 清水惠子
  • Total Pages: 210
  • Publisher: 南山堂