Studies on wound-healing substances from natural products

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Ehime University
• Principal Investigator: SUMIYOSHI Maho Ehime University, 大学院・医学系研究科, 研究員 (60444767)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Yoshiyuki 愛媛大学, 大学院・医学系研究科, 講師 (20294796)
• Project Period (FY): 2007 – 2008
• Keywords: 創傷治癒 / 天然由来化合物 / 紫外線

Research Abstract

低濃度(10pgから100ng/mL)のツボクサ(Centellaasiatica)成分Asiaticosideおよび赤升麻(Astilbethunbergii)成分Eucryphinが、熱傷治癒促進作用をもつことを、マウス熱傷モデル用いて明らかにした。創傷部滲出液の分析、細胞を用いた分析を行い、これら天然物由来化合物が生体の再生能を向上させて創傷治癒を促進していることを明らかにした。

Research Products

• [Journal Article] Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice (2009)
  • Author(s): Sumiyoshi M, Hayashi T, Kimura Y
  • Journal Title: Nat Med(Tokyo) 63 Pages: 130-136
  • Peer Reviewed
• [Journal Article] Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice (2009)
  • Author(s): Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y
  • Journal Title: Eur J Pharmacol 602 Pages: 148-156
  • Peer Reviewed
• [Journal Article] Effects of Red Ginseng extract on ultraviolet B-irradiated skin change in C57BL mice (2008)
  • Author(s): Kim YG, Sumiyoshi M, Kawahira K, Sakanaka M, Kimura Y
  • Journal Title: Phytother Res 22 Pages: 1423-1427
  • Peer Reviewed
• [Journal Article] Effects of ginsenoside Rb_1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas duaring the process of acute burn wound repair (2008)
  • Author(s): Kawahira K, Sumiyoshi M, Sakanaka M, Kimura Y
  • Journal Title: J Ethnopharmacol 117 Pages: 278-284
  • Peer Reviewed
• [Journal Article] Facilitationg action of asiaticoside at low doses on burn wound repair and its mechanism (2008)
  • Author(s): Kimura Y, Sumiyoshi M, Samukawa K, Satake N, Sakanaka M
  • Journal Title: Eur Jpharmacol 584 Pages: 415-423
  • Peer Reviewed
• [Presentation] 低用量長期UVB照射による皮膚老化に対する黒砂糖非ショ糖分画の影響 (2008)
  • Author(s): 木村善行, 住吉真帆, 林輝明
  • Organizer: 日本生薬学会第55回年会
  • Place of Presentation: 長崎大学
  • Year and Date: 2008-09-20
• [Presentation] 低用量長期UVB照射による皮膚老化に対するウコンCurcumalonga L.抽出物の影響 (2008)
  • Author(s): 住吉真帆, 木村善行
  • Organizer: 日本生薬学会第55回年会
  • Place of Presentation: 長崎大学
  • Year and Date: 2008-09-19
• [Presentation] 紅蔘の紫外線B波照射による皮膚老化に及ぼす影響 (2007)
  • Author(s): 木村善行, 住吉真帆, 金永坤, 河平一宏, 阪中雅広
  • Organizer: 日本生薬薬学会第54回年会
  • Place of Presentation: 愛知学院大学薬学部
  • Year and Date: 2007-09-14