2009 Fiscal Year Final Research Report
Analysis of esophagopharyngeal reflux using 24-hr ambulatory pharyngoesophageal impedance and pH monitoring
| Project/Area Number |
19590713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
KAWAMURA Osamu Gunma University, 医学部, 助教 (60292596)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 胃食道咽頭逆流 / 弱酸性逆流 / 胃食道逆流症 / インピーダンス・pHモニタリング / 慢性咳嗽 |
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| Research Abstract |
We studied patients with chronic cough who responded to full-dose PPI therapy, in whom 24-hr pharyngoesophageal impedance and pH monitoring was performed. Most patients with chronic cough responding to PPIs had minor acidic gas reflux and/or swallow-induced weakly acidic and/or acidic reflux in the pharynx. A direct effect of acidic mist or acidic liquid refluxing into the pharynx was suggested to be the cause of their chronic cough. In some patients, symptoms may arise indirectly from gastroesophageal reflux via a vago-vagal reflex.
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