Molecular brain imaging of efferent gastrointestinal signal via bitter taste receptors and the analyses of its physiological function

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: TOMINAGA Kazunari Osaka City University, 大学院・医学研究科, 准教授 (80336768)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Yasuhiro 大阪市立大学, 大学院・医学研究科, 准教授 (40285292) ; WATANABE Toshio 大阪市立大学, 大学院・医学研究科, 准教授 (50336773) ; TANIGAWA Tetsuya 大阪市立大学, 大学院・医学研究科, 講師 (70423879)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Kazuhide 大阪医科大学, 医学部, 教授 (20218697)
• Project Period (FY): 2007 – 2009
• Keywords: 内科 / 消化器病学 / 味覚 / 分子イメージング / 受容体

Research Abstract

Gene expression of 22 kinds of T2R families, bitter taste receptors, was ubiquitously observed in most digestive tracts from the esophagus to the colon by PCR methods. Unfortunately, the detailed localization of them could not be proved even by using various probes of molecular methods. However, a part of the bitter taste receptors may be associated with the delay of gastric emptying.

Research Products

• [Journal Article] Long-term efficacy of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: 7-year follow-up prospective study. (2009)
  • Author(s): Tsumoto C, Tominaga K, Okazaki H, Tanigawa T, Yamagami H, Watanabe K, Nakao T, Koh K, Watanabe T, Fujiwara Y, Yamane T, Oshitani N, Hino M, Higuchi K, Arakawa T
  • Journal Title: Ann Hematol 88(8) Pages: 789-93
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. (2009)
  • Author(s): Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T
  • Journal Title: Biochem Biophys Res Commun 1,382(2) Pages: 252-8
  • Peer Reviewed
• [Journal Article] Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. (2009)
  • Author(s): Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Higuchi K, Takeuchi K, Arakawa T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 297(3) Pages: G506-13
  • Peer Reviewed
• [Journal Article] Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats. (2008)
  • Author(s): Ochi M, Tominaga K, Tanaka F, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T
  • Journal Title: Life Sci 82(15-16) Pages: 862-8
  • Peer Reviewed
• [Journal Article] Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients. (2008)
  • Author(s): Tominaga K, Higuchi K, Ochi M, Kadouchi K, Kawamura E, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Shiomi S, Arakawa T
  • Journal Title: Hepatogastroenterology 55(82-83) Pages: 744-9
  • Peer Reviewed
• [Journal Article] Perfectionism underlying psychological background correlated with the symptoms of functional dyspepsia. (2008)
  • Author(s): Ochi M, Tominaga K, Iketani T, Kadouchi K, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Kiriike N, Arakawa T
  • Journal Title: J Gastroenterol 43(9) Pages: 699-704
  • Peer Reviewed
• [Journal Article] Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity. (2008)
  • Author(s): Tanaka F, Tominaga K, Shiota M, Ochi M, Kuwamura H, Tanigawa T, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Iwao H, Arakawa T
  • Journal Title: Cancer Gene Ther 15(1) Pages: 51-9
  • Peer Reviewed
• [Journal Article] Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent. (2008)
  • Author(s): Watanabe T, Higuchi K, Kobata A, Nishio H, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Takeuchi K, Arakawa T
  • Journal Title: Gut 57(2) Pages: 181-7
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2, 4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism. (2007)
  • Author(s): Sasaki E, Tominaga K, Kuwamura H, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T
  • Journal Title: J Gastroenterol 42(10) Pages: 816-22
  • Peer Reviewed