The Significance of Adiponectin in Atrophic Gastritis and Gastric Carcinogenesis

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590732
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka Medical College
• Principal Investigator: HIGUCHI Kazuhide Osaka Medical College, 医学部, 教授 (20218697)
• Co-Investigator(Kenkyū-buntansha): TOMINAGA Kazunari 大阪市立大学, 大学院・医学研究科, 准教授 (80336768) ; FUJIWARA Yasuhiro 大阪市立大学, 大学院・医学研究科, 准教授 (40285292) ; WATANABE Toshio 大阪市立大学, 大学院・医学研究科, 准教授 (50336773) ; TANIGAWA Tetsuya 大阪市立大学, 大学院・医学研究科, 講師 (70423879)
• Project Period (FY): 2007 – 2009
• Keywords: アディポサイトカイン / アディポネクチン / 炎症 / Helicobacter pylori / 胃炎 / tumor necrosis factor-・

Research Abstract

Adiponectin, one of the adipocytokines which is produced by adipose tissue, has anti-diabetic, anti-atherosclerotic, anti-inflammatory and anti-carcinogenic effects. In this study, we studied the involvement of adiponectin on Helicobacter pylori (H.pylori)-induced gastritis.
1. Adiponectin suppress production of proinflammatory cytokines TNF-・ produced by THP-1 cells stimulated by H.pylori-water soluble extract.
2. Leptin, one of the important adipocitykines as well as adiponectin, promotes the healing of gastric ulcer via upregulation of vascular endothelial growth factor.
3. IL-17A exerts anti-inflammatory effect on H.pylori -induced gastritis through suppression of Th1 differentiation.
4. Bile acids may induce gastric intestinal metaplasia and carcinogenesis through the farnesoid X receptor (FXR), a nuclear receptor for bile acids.

Research Products

• [Journal Article] Bile acids induce cdx2 expression through the fanesoid x receptor in gastric epithelial cells. (2010)
  • Author(s): Xu Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T.
  • Journal Title: J Clin Biochem Nutr. 46(1) Pages: 81-6
  • Peer Reviewed
• [Journal Article] Leptin promotes gastric ulcer healing via upregulation of vascular endothelial growth factor. (2010)
  • Author(s): Tanigawa T, Watanabe T, Otani K, Nadatani Y, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T.
  • Journal Title: Digestion 81(2) Pages: 86-95
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. (2009)
  • Author(s): Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T.
  • Journal Title: Biochem Biophys Res Commun. 382(2) Pages: 252-8
  • Peer Reviewed
• [Journal Article] 胃潰瘍治癒過程におけるレプチンの意義 (2009)
  • Author(s): 谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 樋口和秀, 荒川哲男
  • Journal Title: Progress in Medicine 29巻3号 Pages: 779-781
• [Journal Article] H. pyloriによる胃炎に対するIL-17の抗炎症作用 (2009)
  • Author(s): 大谷恒史, 渡辺俊雄, 谷川徹也, 岡崎博俊, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 荒川哲男
  • Journal Title: 消化器と免疫 45号 Pages: 91-94
• [Presentation] H. pylori感染胃粘膜におけるIL-17の働き (2009)
  • Author(s): 大谷恒史, 渡辺俊雄, 谷川徹也, 岡崎博俊, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 荒川哲男
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07
• [Presentation] Helicobacter pylori感染に対する免疫反応におけるIL-17の役割について (2009)
  • Author(s): 大谷恒史, 渡辺俊雄, 谷川徹也, 亀田夏彦、町田浩久、岡崎博俊, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 荒川哲男
  • Organizer: 第5回日本消化管学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-12
• [Presentation] 胆汁酸は胃上皮細胞においてfarnesoid X核内受容体を介して転写因子CDX2を誘導する (2008)
  • Author(s): 許英姫, 谷川徹也, 岡崎博俊, 渡辺俊雄, 富永和作, 藤原靖弘, 押谷伸英, 荒川哲男
  • Organizer: 第4回日本消化管学会総会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-02-07