2010 Fiscal Year Final Research Report
Interferon-producing killer dendritic cell-based immunotherapy for gastrointestinal cancer
| Project/Area Number |
19590738
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Showa University |
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Principal Investigator |
HIROISHI Kazumasa Showa University, 医学部, 准教授 (80296996)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 樹状細胞 / ナチュラルキラー細胞 / インターフェロン / 免疫療法 / 抗腫瘍効果 |
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| Research Abstract |
Effective methods for inducing interferon-producing killer dendritic cells (IKDCs) in a mouse model were explored. When murine splenocytes were cultured with CpG, Flt-3 ligand, IL-15, and IL-18, the number of IKDCs was increased to 1.34-6.38 times as much as that in splenocytes without any stimulation. Then, the therapeutic effects of IKDC on the established tumors were assessed using a murine poorly immunogenic colorectal cancer, MC38 model. When IKDCs were inoculated in tumor-bearing mice, the outgrowths of the tumors were significantly suppressed compared with those in mice treated with myeloid dendritic cells. Therefore, IKDC-based immunotherapy should be considered for clinical application.
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[Journal Article] Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma.2010
Author(s)
Hiroishi K., Eguchi J., Baba T., Shimazaki T., Ishii S., Hiraide A., Sakaki M., Doi H., Uozumi S., Omori R., Matsumura T., Yanagawa T., Ito T., Imawari M
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Journal Title
J Gastroenterol 45(4)
Pages: 451-458
Peer Reviewed
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