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2008 Fiscal Year Final Research Report

The role of hepatic mitochondrial function in carcinogenesis of chronic hepatitis C

Research Project

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Project/Area Number 19590769
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionYamaguchi University

Principal Investigator

KORENAGA Masaaki  Yamaguchi University, 医学部附属病院, 助教 (70420536)

Project Period (FY) 2007 – 2008
Keywordsミトコンドリア / 鉄過剰状態 / 肝発癌 / 酸化ストレス / 小胞体ストレス / HCVTgM
Research Abstract

C型肝炎ウイルス(HCV)が誘導するミトコンドリアからの酸化ストレスは、ウイルス排除のみならず、ウイルス増殖を抑制するだけで抑えられ肝発癌を抑制する可能性がある。また、HCVが誘導する鉄過剰状態は、ミトコンドリア障害のみならず、小胞体ストレスを誘導し、肝脂肪化を増悪させ発癌を促進すると考えられた。

  • Research Products

    (10 results)

All 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription2008

    • Author(s)
      Nishina S, Hino K, Korenaga M, 他9名
    • Journal Title

      Gastroenterology 34(1)

      Pages: 226-38

    • Peer Reviewed
  • [Journal Article] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication Liver Int2008

    • Author(s)
      Ando M, Korenaga M, Hino K, 他8名
    • Journal Title

      28(8)

      Pages: 1158-66

    • Peer Reviewed
  • [Journal Article] Effects of a late evening snack combined with alpha-glucosidase inhibitor on liver cirrhosis2008

    • Author(s)
      Korenaga K, Korenaga M, Uchida K, 他5名
    • Journal Title

      Hepatol Res 38

      Pages: 1087-1097

    • Peer Reviewed
  • [Journal Article] Stronger Neo-Minophagen C^<TM>, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein2007

    • Author(s)
      Hidaka I, Hino K, Korenaga M, 他5名
    • Journal Title

      Liver Int 27

      Pages: 845-53

    • Peer Reviewed
  • [Journal Article] The effect of supplementation with branched-chain amino acids in patients with liver cirrhosis2007

    • Author(s)
      Urata Y, Okita K, Korenaga K, 他5名
    • Journal Title

      37(7)

      Pages: 510-6

  • [Presentation] Analysis of gene expression related to the lipid and glucose metabolism in iron-overloded transgenic mice expressing the hepatitis C virus polyprotein2008

    • Author(s)
      Korenaga M et.al.
    • Organizer
      第59回AASLD(TheAmerican Association for the Study of Liver Disease)
    • Place of Presentation
      San Francisco CA USA
    • Year and Date
      2008-11-01
  • [Presentation] Analysis of gene expression related to the lipid and glucose metabolism in iron-overloded transgenic mice expressing the hepatitis C virus polyprotein2008

    • Author(s)
      Korenaga M et.al.
    • Organizer
      第59回AASLD(The American Association for the Study ofLiver Disease)
    • Place of Presentation
      San Francisco CA USA
    • Year and Date
      2008-11-01
  • [Presentation] Cosupplementation with vitamin E and coenzyme Q(10) reduces iron-overloaded induced hepatic steatosisin transgenic mice expressing the hepatitis c virus polyprotein2007

    • Author(s)
      Korenaga M et.al.
    • Organizer
      第58回AASLD(The American Association for the Study of Liver Disease)
    • Place of Presentation
      Boston MA USA
    • Year and Date
      2007-11-04
  • [Presentation] Inhibition of viral replication prevents HCV-induced mitochondrial respiratory dysfunction in a genome-length replicon system2007

    • Author(s)
      Korenaga M et.al.
    • Organizer
      APDW(Asian Pacific Digestive Week)
    • Place of Presentation
      Kobe Japan
    • Year and Date
      2007-10-18
  • [Book] 酸化ストレスと肝疾患第4巻, C型肝炎ウイルスが惹起する肝脂肪化と酸化ストレス2008

    • Author(s)
      是永匡紹
    • Total Pages
      36-42
    • Publisher
      メディカルジャーナル社

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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