2009 Fiscal Year Final Research Report
マクロファージと肝障害:Toll-like受容体制御による新規治療の探索
| Project/Area Number |
19590784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nara Medical University |
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Principal Investigator |
FUKUI Hiroshi Nara Medical University, 医学部, 教授 (80145838)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJIMOTO Tatsuhiro
KITAZAWA Hiroyuki
KAWARATANI Hideto
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| Project Period (FY) |
2007 – 2009
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| Keywords | Toll-like受容体 / マクロファージ / 非アルコール性脂肪肝炎(NASH) / 急性肝不全 / Kupffer細胞 / TNF-α / エンドトキシン |
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| Research Abstract |
Toll-like receptor 4 (TLR4) was upregulated and TNF-α production was increased with the progression of liver injury in the CDAA-fed nonalcoholic steatohepatitis and galactosamine(GalN)-induced acute hepatic failure in rats. Cytokine regulator was effective to NASH rats and alcohol-fed rats. TLR4 inhibitor was effective to AHF and improved survival of GalN/LPS induced lethal AHF in rats.
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