2009 Fiscal Year Final Research Report
The involvement of stress and central neuropeptide on the progression of nonalcoholic steatohepatitis
| Project/Area Number |
19590787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
YONEDA Masashi Aichi Medical University, 医学部, 教授 (30261407)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Haruhisa 愛知医科大学, 医学部, 教授 (60326139)
NAKADE Yukiomi 愛知医科大学, 医学部, 講師 (70431400)
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| Project Period (FY) |
2007 – 2009
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| Keywords | NASH / ストレス / CRF |
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| Research Abstract |
It is generally accepted that the etiology of nonalcoholic steatohepatitis (NASH) remains to be unknown. The involvement of stress or central neuropeptide on the progression for NASH was investigated in this study. We have demonstrated that restraint stress significantly aggravated liver function on acute fatty liver model in rats and an endogenous corticotropine releasing factor (CRF), which is known as a neuropeptide in the brain was involved. We have also shown that repeated restraint stress has a tendency to make worse fatty change of liver in NASH model. Although the etiology of NASH remains to be elucidated, stress might be involved in the progression for NASH.
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Research Products
(22 results)
