Role of pentraxin 3 in the development and progression of heart failure

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590804
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University (2008); Yamagata University (2007)
• Principal Investigator: TAKEISHI Yasuchika Fukushima Medical University, 医学部, 教授 (40272067)
• Project Period (FY): 2007 – 2008
• Keywords: pentraxin 3 / innate immunity / remodeling / inflammation / heart failure / hypertrophy

Research Abstract

体液性の自然免疫を担うpentraxin 3が心不全の発症と進展に関与していることを、pentraxin 3ノックアウトマウスと心臓選択的pentraxin 3過剰発現トランスジェニックマウスを用いて明らかにした。圧負荷による心肥大、心機能低下、線維化、生存率の低下はノックアウトマウスで抑制された。反対に、心臓選択的 pentraxin 3過剰発現トランスジェニックマウスでは、圧負荷に対する心肥大、心機能低下、線維化はより顕著で、生存率も低かった。臨床的には、血漿中のpentraxin 3濃度が高い心不全症例では心血管死を高頻度に認めた。また、心嚢液中のpentraxin 3濃度の高い例では心機能が低値で、開心術後の回復が遷延した。自然免疫が感染症の制御だけでなく、心不全の発症・進展機序として関与していることが明らかになった。

Research Products

• [Journal Article] Diacylglycerol kinase ζ attenuates pressure overload-induced cardiac hypertrophy (2009)
  • Author(s): 29. Harada M, Takeishi Y, Arimoto T, Niizeki T, Kitahara T, Goto K, Walsh RA, Kubota I
  • Journal Title: Circulation Journal 71 Pages: 276-282
  • Peer Reviewed
• [Journal Article] Altered expression of antimicrobial molecules in cigarette smoke-exposed emphysematous mice lungs (2008)
  • Author(s): Shibata Y, Abe S, Inoue S, Takabatake N, Igarashi A, Takeishi Y, Sato M, Kubota I
  • Journal Title: Respirology 13 Pages: 1061-1065
  • Peer Reviewed
• [Journal Article] Association of CC chemokine linage 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population : the Takahata study (2008)
  • Author(s): Konta T, Emi M, Toriyama S, Ariumi H, Ishii M, Takasaki S, Ikeda A, Ichikawa K, Shibata Y, Takabatake N, Takeishi Y, Kato T, Kawata S, Kubota I
  • Journal Title: Journal of Human Genetics 53 Pages: 267-274
  • Peer Reviewed
• [Journal Article] Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension (2008)
  • Author(s): Takase B, Takeishi Y, Hirai T, Lee J, Uzui H, Senda S, Miwa K, Hiraoka Y, Kinugawa T, Hosokawa R, Fujita M
  • Journal Title: Circulation Journal 72 Pages: 764-769
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase ζ rescues Gαq-induced heart failure in transgenic mice (2008)
  • Author(s): Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Koyama Y, Goto K, Mende U, Kubota I
  • Journal Title: Circulation Journal 72 72 Pages: 309-317
  • Peer Reviewed
• [Journal Article] ζ inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus (2008)
  • Author(s): Bilim O, Takeishi Y, Kitahara T, Arimoto T, Niizeki T, Sasaki T, Kubota I : Diacylglycerol kinase
  • Journal Title: Cardiovascular Diabetology 7 Pages: 2-12
  • Peer Reviewed
• [Journal Article] Diacylglycerol Kinase-εrestores cardiac dysfunction under chronic pressure overload : a new specific regulator of Gαq signaling cascade (2008)
  • Author(s): Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Ishino M, Bilim O, Sasaki T, Nakajima O, A R, Goto K, Kubota I
  • Journal Title: American Journal of Physiology(Heart and Circulatory Physiology) 295 Pages: H245-H255
  • Peer Reviewed
• [Journal Article] Electroanatomical mapping in partial atrial standstill for visualization of atrial viability and a suitable pacing site (2008)
  • Author(s): Arimoto T, Sukekawa H, Takayama S, Ikeno E, Takeishi Y, Kubota I
  • Journal Title: Pacing and Clinical Electrophysiology 31 Pages: 509-512
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice (2008)
  • Author(s): Kitahara T, Takeishi Y, Harada M, Niizeki T, Suzuki S, Sasaki T, Ishino M, Bilim O, Nakajima O, Kubota I
  • Journal Title: Cardiovascular Research 80 Pages: 40-46
  • Peer Reviewed
• [Journal Article] Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII (2008)
  • Author(s): Souri M, Koseki-Kuno S, Takeda N, Yamakawa M, Takeishi Y, Degen J, Ichinose A
  • Journal Title: Thrombosis and Haemostasis 99 Pages: 401-408
  • Peer Reviewed
• [Journal Article] Overexpression of diacylglycerol kinase ζ inhibits endothelin-1-induced decreases in Ca^<2+> transients and cell shortening in mouse ventricular myocytes (2008)
  • Author(s): Nishimaru K, Arimoto T, Takeishi Y, Kubota I, Ishii K, Endoh M
  • Journal Title: Journal of Molecular and Cellular Cardiology 44 Pages: 520-526
  • Peer Reviewed
• [Journal Article] Pentosidine and soluble receptor for advanced glycation end-product are important prognostic factors independent of renal function in heart failure (2008)
  • Author(s): Takeishi Y, Koyama Y
  • Journal Title: Journal of Cardiac Failure 14 Pages: 627-628
  • Peer Reviewed
• [Journal Article] Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure (2008)
  • Author(s): Suzuki S, Takeishi Y, Niizeki T, Koyama Y, Kitahara T, Sasaki T, Sagara M, Kubota I
  • Journal Title: American Heart Journal 155 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure (2008)
  • Author(s): Niizeki T, Takeishi Y, Arimoto T, Nozaki N, Hirono O, Watanabe T, Nitobe J, Miyashita T, Miyamoto T, Koyama Y, Kitahara T, Suzuki S, Sasaki T, Kubota I
  • Journal Title: Circulation Journal 72 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy (2008)
  • Author(s): Niizeki T, Takeishi Y, Watanabe T, Nitobe J, Miyashita T, Miyamoto T, Kitahara T, Suzuki S, Sasaki T, Bilim O, Ishino M, Kubota I
  • Journal Title: The American Journal of Cardiology 102 Pages: 606-610
  • Peer Reviewed
• [Journal Article] Relationship between antinuclear antibody and microalbuminuria in the general population : the Takahata study (2008)
  • Author(s): Ishikawa M, Konta T, Hao Z, Takasaki S, Abiko H, Takahashi T, Ikeda A, Ichikawa K, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I
  • Journal Title: Clinical and Experimental Nephrology 12 Pages: 200-206
  • Peer Reviewed
• [Journal Article] Risk stratification of chronic heart failure patients by multiple biomarkers -Implications of BNP (2008)
  • Author(s): Ishino M, Takeishi Y, Niizeki T, Watanabe T, Nitobe J, Miyamoto T, Miyashita T, Kitahara T, Suzuki S, Sasaki T, Bilim O, Kubota I
  • Journal Title: H-FABP, and PTX3-. Circulation Journal 72 Pages: 1800-1805
  • Peer Reviewed
• [Journal Article] Short cardiac iodine-123-metaiodobenzylguanidine imaging protocol in heart failure (2008)
  • Author(s): Arimoto T, Sukekawa H, Harada M, Takayama S, Ikeno E, Nisugi K, Takeishi Y, Kubota I
  • Journal Title: Circulation Journal 72 Pages: 1106-1111
  • Peer Reviewed
• [Journal Article] Soluble Receptor for advanced glycation end products(RAGE)is a prognostic factor for heart failure (2008)
  • Author(s): Koyama Y, Takeishi Y, Niizeki T, Suzuki S, Kitahara T, Sasaki T, Kubota I
  • Journal Title: Journal of Cardiac Failure 14 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Usefulness of intensity variation in the left atrial appendage with contrast echocardiography to predict ischemic stroke recurrence in patients with atrial fibrillation (2008)
  • Author(s): Okuyama H, Hirono O, Tamura H, Nishiyama S, Takeishi Y, Kayama T, Kubota I
  • Journal Title: The American Journal of Cardiology 101 Pages: 1630-1637
  • Peer Reviewed
• [Journal Article] 新しい血管炎症マーカーPTX3の心不全患者における予後予測因子としての役割 (2008)
  • Author(s): 鈴木聡, 竹石恭知, 佐々木敏樹, 加藤重彦, 北原辰郎, 小山容, 新関武史, 久保田功, 相良三奈
  • Journal Title: 心臓 40 Pages: 365-372
  • Peer Reviewed
• [Journal Article] 急性心筋梗塞症例における発症から病院到着までの時間が医療費と予後にあたえる影響 (2008)
  • Author(s): 西山悟史, 廣野摂, 竹石恭知, 柴田洋雄, 吉田敏晴, 久保田功
  • Journal Title: 心臓 40 Pages: 838-844
  • Peer Reviewed
• [Journal Article] たこつぼ心筋症患者の心理社会的特性に関するケース・コントロール研究 (2008)
  • Author(s): 三谷智子, 藤田正俊, 小川久雄, 木下法之, 水重克文, 奥村 謙, 木原康樹, 竹石恭知, 野原隆司, 宮崎俊一, 三國谷淳, 李鐘大, 平井忠和, 渡邊能行
  • Journal Title: 心臓 40 Pages: 1081-1086
  • Peer Reviewed
• [Journal Article] A nonfunctioning single nucleotide polymorphism in olfactory receptor gene family is associated with the forced expiratory volume in the first second/the forced vital capacity values of pulmonary function test in a Japanese population (2007)
  • Author(s): Takabatake N, Toriyama S, Takeishi Y, Shibata Y, Konta T, Inoue S, Abe S, Igarashi A, Tokairin Y, Ishii M, Koyano S, Emi M, Kato T, Kawata S, Kubota I
  • Journal Title: Biochemical and Biophysical Research Communications 364 Pages: 662-667
  • Peer Reviewed
• [Journal Article] An angiotensin II type-I receptor blocker, olmesartan medoxomil, attenuates lipid peroxidation in renal injury induced by subtotal nephrectomy (2007)
  • Author(s): Takahashi T, Konta T, Takasaki S, Ichikawa K, Takeishi Y, Kubota I
  • Journal Title: Clinical and Experimental Nephrology 11 Pages: 202-208
  • Peer Reviewed
• [Journal Article] Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes (2007)
  • Author(s): Koyama Y, Takeishi Y, Takahashi H, Shishido T, Arimoto T, Niizeki T, Harada M, Suzuki S, Kitahara T, Sasaki T, Kubota I
  • Journal Title: Cardiovascular Drugs and Therapy 21 Pages: 69-72
• [Journal Article] Cardiac sympathetic denervation and ongoing myocardial damage for prognosis in early stages of heart failure (2007)
  • Author(s): Arimoto T, Takeishi Y, Niizeki T, Nozaki N, Hirono O, Watanabe T, Nitobe J, Tsunoda Y, Suzuki S, Koyama Y, Kitahara T, Okada A, Takahashi K, Kubota I
  • Journal Title: Journal of Cardiac Failure 13 Pages: 34-41
  • Peer Reviewed
• [Journal Article] Cardiac-specific overexpression of diacylglycerol kinase ζ attenuates left ventricular remodeling and improves survival after myocardial infarction. American Journal of Physiology (2007)
  • Author(s): Niizeki T, Takeishi Y, Arimoto T, Takahashi H, Shishido T, Koyama Y, Goto K, Walsh RA, Kubota I
  • Journal Title: Heart and Circulatory Physiology 292 Pages: H1105-H1112
  • Peer Reviewed
• [Journal Article] Circulating levels of heart-type fatty acid-binding protein in a general Japanese population-Effects of age (2007)
  • Author(s): Niizeki T, Takeishi Y, Takabatake N, Shibata Y, Konta T, Kato T, Kawata S, Kubota I
  • Journal Title: gender and physiologic characteristics-Circulation Journal 71 Pages: 1452-1457
  • Peer Reviewed
• [Journal Article] Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients (2007)
  • Author(s): Tamura H, Hirono O, Okuyama H, Liu L, Nishiyama S, Takeishi Y, Kayama T, Kubota I
  • Journal Title: Circulation Journal 71 Pages: 1573-1579
  • Peer Reviewed
• [Journal Article] Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients (2007)
  • Author(s): Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, Watanabe T, Nitobe J, Harada M, Suzuki S, Koyama Y, Kitahara T, Sasaki T, Kubota I
  • Journal Title: Journal of Cardiac Failure 13 Pages: 120-127
  • Peer Reviewed
• [Journal Article] High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure (2007)
  • Author(s): Koyama Y, Takeishi Y, Arimoto T, Niizeki T, Shishido T, Takahashi H, Nozaki N, Hirono O, Tsunoda Y, Nitobe J, Watanabe T, Kubota I
  • Journal Title: failure. Journal of Cardiac Failure 13 Pages: 199-206
  • Peer Reviewed
• [Journal Article] Linkage disequilibrium analyses of natriuretic peptide precursor β locus reveal risk haplotype conferring high plasma BNP levels (2007)
  • Author(s): Takeishi Y, Toriyama S, Takabatake N, Shibata Y, Konta T, Emi M, Kato T, Kawata S, Kubota I
  • Journal Title: Biochemical and Biophysical Research Communications 362 Pages: 480-484
  • Peer Reviewed
• [Journal Article] Responsiveness to dobutamine stimulation in patients with left ventricular apical ballooning syndrome (2007)
  • Author(s): Fujiwara S, Takeishi Y, Isoyama S, Aono G, Takizawa K, Honda H, Otomo T, Mitsuoka M, Itoh Y, Terashima M, Kubota I, Meguro T
  • Journal Title: The American Journal of Cardiology 100 Pages: 1600-1603
  • Peer Reviewed
• [Journal Article] Serum carboxy-terminal telopeptide of type I collagen (ICTP) predicts cardiac events in chronic heart failure patients with preserved left ventricular systolic function (2007)
  • Author(s): Kitahara T, Takeishi Y, Arimoto T, Niizeki T, Koyama Y, Sasaki T, Suzuki S, Nozaki N, Hirono O, Nitobe J, Watanabe T, Kubota I
  • Journal Title: Circulation Journal 71 Pages: 929-935
  • Peer Reviewed
• [Journal Article] Serum resistin is associated with high risk in patients with congestive heart failure.-A novel link between metabolic signals and heart failure- (2007)
  • Author(s): Takeishi Y, Niizeki T, Arimoto T, Nozaki N, Hirono O, Nitobe J, Watanabe T, Takabatake N, Kubota I
  • Journal Title: Circulation Journal 71 Pages: 460-464
  • Peer Reviewed
• [Journal Article] 山形県急性心筋梗塞・突然死発症登録評価研究事業平成17年のまとめ (2007)
  • Author(s): 西山悟史, 廣野摂, 竹石恭知, 久保田功, 武田憲夫, 有海躬行, 遠藤克二
  • Journal Title: 山形県医師会会報 665 Pages: 20-24
• [Presentation] Adaptive servo ventilation improves cardiac function in heart failure patients with cheyne-stokes respiration (2009)
  • Author(s): Yoshihisa A, Suzuki H, Sato T, Saitoh S, Ishibashi T, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Quantitative analysis of change in early diastolic strain rate for adenosine-induced myocardial dysfunction (2009)
  • Author(s): Iwai-Takano M, Oikawa M, Machii H, Sugimoto K, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in advanced glycation end products (AGE) /RAGE-signaling pathway (2009)
  • Author(s): Kamioka M, Ishibashi T, Sugimoto K, Yamagishi S, Ohkawara H, Sakamoto N, Ando K, Nagai R, Matsui T, Takuwa Y, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Metabolic regulation of coronary vascular tone : Role of hydrogen peroxide,adenosine 5'-diphosphate, and angiotensin (2009)
  • Author(s): Kaneshiro T, Saitoh S, Machii H, Yamaguchi O, Ishibashi T, Maruyama Y, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Kubota I : Serum heat shock protein 60 level is related to severity and prognosis in chronic heart failure patients (2009)
  • Author(s): Ohtaki Y, Niizeki T, Itoh M, Daidoji H, Oguma M, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Serum NT-proBNP level for diagnosis of diastolic heart failure in Japanese population (2009)
  • Author(s): Iwai-Takano M, Kobayashi A, Oikawa M, Watanabe T, Sato T, Ishibashi T, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Regulation of coronary vascular tone via redox modulation in the α1-adrebergic-angiotensin-endothekin axis of the myocardium (2009)
  • Author(s): Yamaguchi O, Saitoh S, Kaneshiro T, Machii H, Ishibashi T, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] SPECT/CT fusion Image is useful for the diagnosis of coronary artery stenosis with calcification (2009)
  • Author(s): Machii H, Oikawa M, Iwai-Takano M, Mizukami H, Sato T, Sakamoto N, Sugimoto K, Ishikawa K, Saitoh S, Ishibashi T, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Rapid improvement of impaired endothelium- dependent vasodilation and Rac1/NADPH oxidase-derived ROS generation in vivo by pravastatin (2009)
  • Author(s): Ohkawara H, Ishibashi T, Sugimoto K, Kamioka M, Uekita H, Saitoh S, Kaneshiro T, Inoue N, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Hydrogen peroxide : a feed-forward dilator that couples myocardial metabolism to coronary blood flow (2009)
  • Author(s): Saitoh S, Kaneshiro T, Yamaguchi O, Machii H, Ishibashi T, Takeishi Y
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Risk stratification of the elderly patients with chronic heart failure by multiple biomarkers (2009)
  • Author(s): Ohtaki Y, Niizeki T, Itoh M, Oguma M, Takeishi Y, Kubota I
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Risk stratification by combination of serum neopterin and TNFα in patients with heart failure (2009)
  • Author(s): Sasaki T, Takeishi Y, Suzuki S, Kitahara T, Katoh S, Ishino M, Shishido T, Watanabe T, Kubota I
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] 8-Hydroxy-2'-deoxyguanosine predicts adverse clinical outcomes in patients with heart failure (2009)
  • Author(s): Suzuki S, Shishido T, Sasaki T, Kitahara T, Katoh S, Ishino M, Watanabe T, Takeishi Y, Kubota I
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-22
• [Presentation] Therapeutic targeting RAGE/MT-1-MMP/Rac1 axis in redox- sensitive signaling pathway in diabetic vascular remodeling (2008)
  • Author(s): Kamioka M, Ishibashi T, Sugimoto K, Ohkawara H, Sakamoto N, Uekita H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] High-mobility group box 1 restores cardiac dysfunction after myocardial infarction in transgenic mice (2008)
  • Author(s): Kitahara T, Takeishi Y, Shishido T, Suzuki S, Kato S, Sasaki T, Bilim O, Ishino M, Kubota I
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] Receptor for advanced glycation end products (RAGE) plays an integral role in non-diabetic atherosclerosis and oxidized LDL stimulation (2008)
  • Author(s): Uekita H, Ishibashi T, Shiomi M, Sugimoto K, Ohkawara H, Kamioka M, Yamagishi S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] Metabolic control in the coronary vascular tone : Metabolic control in the coronary vascular tone : role of hydrogen peroxide, ADP, and angiotensin (2008)
  • Author(s): Kaneshiro T, Saitoh S, Yamaguchi O, Ishibashi T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] Regulation of coronary vascular tone via redox modulation in the α1-adrenergic angiotensin-endothelin axis of the myocardium (2008)
  • Author(s): Yamaguchi O, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] High serum level of neopterin is a risk factor of patients with heart failure (2008)
  • Author(s): Sasaki T, Takeishi Y, Shishido T, Watanabe T, Nitobe J, Miyamoto T, Miyashita T, Nishiyama S, Kubota I
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] Serum midkine predicts cardiac events in chronic heart failure patients (2008)
  • Author(s): Kitahara T, Takeishi Y, Shishido T, Watanabe T, Nitoube J, Miyamoto T, Miyashita T, Nishiyama S, Kubota I
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] Multiple biomarkers approach for risk stratification in heart failure patients (2008)
  • Author(s): Ishino M, Takeishi Y, Shishido T, Watanabe T, Nitobe J, Miyamoto T, Miyashita T, Nishiyama S, Kubota I
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-12
• [Presentation] Soluble receptor for advanced glycation end products is a prognostic factor for heart failure (2008)
  • Author(s): Koyama Y, Takeishi Y, Niizeki T, Suzuki S, Kitahara T, Sasaki T, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] High serum level of neopterin is a risk factor of patients with heart failure (2008)
  • Author(s): Sasaki T, Takeishi Y, Koyama Y, Suzuki S, Kitahara T, Niizeki T, Katoh S, Ishino M, Nozaki N, Hirono O, Watanabe T, Nitobe J, Miyamoto T, MIYASHITA T, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Cardiac-specific overexpression of diacylglycerol kinase ζ prevents the generation of cardiac arrhythmias in constitutively active Gαq- expressed transgenic mice (2008)
  • Author(s): Hirose M, Takeishi Y, Niizeki T, Kubota I, Yamada M
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Diacylglycerol kinase α exacerbates cardiac injury after ischemia/ reperfusion in transgenic mouse hearts (2008)
  • Author(s): Sasaki T, Takeishi Y, Kitahara T, Niizeki T, Suzuki S, Katoh S, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Multiple biomarkers approach for risk stratification in heart failure patients (2008)
  • Author(s): Ishino M, Takeishi Y, Niizeki T, Koyama Y, Suzuki S, Kitahara T, Sasaki T, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Short cardiac iodine-123-metaiodobenzylguanidine protocol and B-type natriuretic peptide for prognosis in heart failure (2008)
  • Author(s): Arimoto T, Sukekawa H, Harada M, Ikeno E, Takeishi Y
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Anti-inflammatory effects of short-term treatment with nocturnal oxygen therapy for chronic heart failure patients with sleep apnea syndrome (2008)
  • Author(s): Suzuki S, Nozaki N, Takeishi Y, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Diacylglycerol kinase ζ inhibits myocardial atrophy and systolic dysfunction in streptozotocin-induced diabetes mellitus (2008)
  • Author(s): Bilim O, Takeishi Y, Kitahara T, Arimoto T, Niizeki T, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Atrial endothelial impairment induced by innate immune may cause atrial thrombosis (2008)
  • Author(s): Katoh S, Watanabe T, Suzuki S, Kitahara T, Sasaki T, Niizeki T, Miyashita T, Miyamoto T, Nitobe J, Hirono O, Nozaki N, Takeishi Y, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Heart-type fatty acid-binding protein levels predict the occurrence of appropriate implantable cardioverter defibrillator therapy for ventricular tachycardia/fibrillation (2008)
  • Author(s): Ishino M, Takeishi Y, Niizeki T, Koyama Y, Suzuki S, Kitahara T, Sasaki T, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Long-term follow-up after catheter ablation of slow pathway in high-aged patients with atrioventricular nodal reentrant tachycardia (2008)
  • Author(s): Watanabe T, Katoh S, Miyashita T, Miyamoto T, Nitobe J, Hirono O, Nozaki N, Takeishi Y, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Contrast arrival time derived from multislice computed tomography is the novel parameter for assessing global cardiac function (2008)
  • Author(s): Tamura H, Nitobe J, Ishino M, Iwayama T, Takeishi Y, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Systemic atherosclerosis in cases with metabolic syndrome may originate from aortic arch (2008)
  • Author(s): Nishiyama S, Hirono O, Okuyama H, Tamura H, Takeishi Y, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Pentraxin 3 (PTX3) predicts adverse clinical outcomes in heart failure patients with preserved left ventricular systolic function (LVSF) (2008)
  • Author(s): Suzuki S, Takeishi Y, Sasaki T, Niizeki T, Koyama Y, Kitahara T, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080308-30
• [Presentation] Diacylglycerol kinase-ε restores cardiac dysfunction under chronic pressure overload : a new specific regulator of Gαq signaling cascade (2008)
  • Author(s): 30. Niizeki T, Takeishi Y, Koyama Y, Kitahara T, Suzuki S, Sasaki T, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080308-30
• [Presentation] Serum midkine predicts cardiac events in chronic heart failure patients (2008)
  • Author(s): Kitahara T, Takeishi Y, Koyama Y, Niizeki T, Suzuki S, Sasaki T, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080308-30
• [Presentation] Multiple biomarkers for the prediction of cardiac events in chronic heart failure (CHF) patients (2008)
  • Author(s): Niizeki T, Takeishi Y, Koyama Y, Suzuki S, Kitahara T, Sasaki T, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080308-30
• [Presentation] Diacylglycerol kinase-ζ rescues Gαq-induced heart failure in transgenic mice (2008)
  • Author(s): Niizeki T, Takeishi Y, Koyama Y, Suzuki S, Kitahara T, Sasaki T, Ishino M, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080308-30
• [Presentation] Elevated circulating levels of platelet-derived microparticles are associated with the left atrial thrombus formation in patients with ischemic stroke (2008)
  • Author(s): Tamura H, Hirono O, Okuyama H, Nishiyama S, Takeishi Y, Kubota I
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080308-30
• [Presentation] Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion in transgenic mouse hearts (2007)
  • Author(s): Sasaki T, Takeishi Y, Kitahara T, Koyama Y, Niizeki T, Suzuki S, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Diacylglycerol kinase-ε prevents cardiac hypertrophy and fibrosis induced by aortic banding : A new specific regulator of Gαq signaling cascade (2007)
  • Author(s): Niizeki T, Takeishi Y, Koyama Y, Kitahara T, Suzuki S, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Diacylglycerol kinase-ε rescues Gαq-induced heart failure (2007)
  • Author(s): Niizeki T, Takeishi Y, Koyama Y, Kitahara T, Suzuki S, Mende U, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Soluble receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure (2007)
  • Author(s): Koyama Y, Takeishi Y, Niizeki T, Suzuki S, Kitahara T, Sasaki T, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Increased ratio of the diastolic mitral annular velocities is associated with left atrial appendage thrombus formation in acute ischemic stroke patients with sinus rhythm (2007)
  • Author(s): Hirono O, Tamura H, Okuyama H, Nishiyama S, Takeishi Y, Kayama T, Kubota I
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Elevated circulating levels of platelet-derived microparticles are associated with the thrombus formation in the left atrial appendage in patients with ischemic stroke that is resistant to anti-coagulant therapies (2007)
  • Author(s): Tamura H, Hirono O, Okuyama H, Nishiyama S, Takeishi Y, Kayama T, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Combined evaluation of circulating platelet derived microparticles and brain natriuretic peptide is a novel predictor for the occurrence of cardioembolic stroke (2007)
  • Author(s): Tamura H, Hirono O, Okuyama H, Nishiyama S, Takeishi Y, Kayama T, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Multiple biomarkers for the prediction of cardiac events in chronic heart failure patients (2007)
  • Author(s): Niizeki T, Takeishi Y, Koyama Y, Kitahara T, Suzuki S, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 20071104-07
• [Presentation] Association of haplotype (rs2280789 A/rs3817655 A) within intron 1 and 2 of CCL5 gene with albuminuria in non-diabetic Japanese general population : The Takahata Study (2007)
  • Author(s): Konta T, Emi M, Toriyama S, Ariumi H, Takasaki S, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I
  • Organizer: The American Society of Nephrology 40th Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 20071031-1105
• [Presentation] 冠動脈疾患患者における血漿中Pentraxin 3(PTX3)濃度の検討 (2007)
  • Author(s): 佐々木敏樹, 竹石恭知, 鈴木聡, 小山容, 新関武史, 北原辰郎, 久保田功
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 20070910-12
• [Presentation] 新しい血管炎症マーカーPTX3の慢性心不全患者における予後予測因子としての役割 (2007)
  • Author(s): 竹石恭知, 鈴木聡, 久保田功
  • Organizer: 第104回日本内科学会総会・講演会
  • Place of Presentation: 大阪
  • Year and Date: 20070403-05
• [Book] 循環器の生物学8.自然免疫と循環器疾患.Annual Review循環器2007(山口徹, 高本眞一, 中澤誠, 小室一成編) (2007)
  • Author(s): 竹石恭知
  • Total Pages: 48-54
  • Publisher: 中外医学社
• [Book] アデノシン負荷心筋血流イメージング. 負荷心筋血流イメージングポケットマニュアル(中田智明編) (2007)
  • Author(s): 竹石恭知
  • Total Pages: 28-31
  • Publisher: メディカルレビュー社