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2008 Fiscal Year Final Research Report

Analysis for the association between mobilization of endothelial progenitor cells and prognosis in patients with acute myocardial infarction

Research Project

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Project/Area Number 19590811
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

NUMAGUCHI Yasushi  Nagoya University, 医学部, 寄附講座准教授 (90378224)

Co-Investigator(Kenkyū-buntansha) MUROHARA Toyoaki  名古屋大学, 大学院・医学系研究科, 教授 (90299503)
SHINTANI Satoshi  名古屋大学, 大学院・医学系研究科, 講師 (20309777)
SHIBATA Rei   (70343689)
Project Period (FY) 2007 – 2008
Keywords心筋梗塞 / 内皮前駆細胞 / 再生医学 / 脂肪酸代謝 / アディポカイン
Research Abstract

本研究では、急性心筋梗塞発症時に血管内皮前駆細胞(EPC)が骨髄より動員される現象に着目し、急性期のEPCの動態と慢性期での心筋回復の機序や予後との相関について解析した。分化型EPCを有する患者や血中アディポネクチン濃度の高い患者は、そうでない患者より心血管病を発症したものが有意に少なかった(P<0.05)。これにより急性期のEPCの分化度とアディポネクチン濃度が遠隔期の心筋機能の生体マーカーとして機能しうることが推察された。

  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (7 results)

  • [Journal Article] Mesenchymal Stem Cell-Based Gene Therapy with Prostacyclin Synthase Enhanced Neovascularization in Hindlimb Ischemia2009

    • Author(s)
      Ishii M, Numaguchi Y, Okumura K, Kubota R, Ma X, Murakami R, Naruse K, Murohara T
    • Journal Title

      Atherosclerosis (in press)

    • Peer Reviewed
  • [Journal Article] Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men2009

    • Author(s)
      Miura M, Numaguchi Y, Ishii M, Kubota R, Takeuchi T, Imamura A, Murakami R, Kondo T, Okumura K, Murohara T
    • Journal Title

      Circ J (in press)

    • Peer Reviewed
  • [Journal Article] Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis2009

    • Author(s)
      Kondo K, Shintani S, Shibata R, Murakami H, Murakami R, Imaizumi M, Kitagawa Y, Murohara T
    • Journal Title

      Arterioscler Thromb Vasc Biol 29(1)

      Pages: 61-66

    • Peer Reviewed
  • [Journal Article] Adiponectin promotes endothelial progenitor cell number and function2008

    • Author(s)
      Shibata R, Skurk C, Ouchi N, Galasso G, Kondo K, Ohashi T, Shimano M, Kihara S, Murohara T, Walsh K
    • Journal Title

      FEBS Lett 582(11)

      Pages: 1607-1612

    • Peer Reviewed
  • [Journal Article] Nifedipine improves endothelial function : role of endothelial progenitor cells2008

    • Author(s)
      Sugiura T, Kondo T, Kureishi-Bando Y, Numaguchi Y, Yoshida O, Dohi Y, Kimura G, Ueda R, Rabelink TJ, Murohara T
    • Journal Title

      Hypertension 52(3)

      Pages: 491-498

    • Peer Reviewed
  • [Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction2008

    • Author(s)
      Shibata R, Numaguchi Y, Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N, Murohara T
    • Journal Title

      Am J Cardiol 101(12)

      Pages: 1712-1715

    • Peer Reviewed
  • [Journal Article] The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects : the significance of plasma adiponectin levels2008

    • Author(s)
      Imamura A, Takahashi R, Murakami R, Kataoka H, Cheng XW, Numaguchi Y, Murohara T, Okumura K
    • Journal Title

      Eur J Endocrinol 158(2)

      Pages: 189-195

    • Peer Reviewed
  • [Journal Article] Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis2008

    • Author(s)
      Li P, Kondo T, Numaguchi Y, Kobayashi K, Aoki M, Inoue N, Okumura K, Murohara T
    • Journal Title

      Hypertension 51(2)

      Pages: 252-258

    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells2007

    • Author(s)
      Yamada T, Kondo T, Numaguchi Y, Tsuzuki M, Matsubara T, Manabe I, Sata M, Nagai R, Murohara T
    • Journal Title

      Arterioscler Thromb Vasc Biol 27(11)

      Pages: 2363-2369

    • Peer Reviewed
  • [Presentation] 再生医療治療時におけるカルシウム拮抗薬シルニジピンの腎機能保護効果について2008

    • Author(s)
      沼口靖
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      福岡マリンメッセ
    • Year and Date
      20080328-30
  • [Presentation] 新規アンギオテンシン受容体(AT4R)の動脈傷害後における血栓閉鎖に関する役割について2008

    • Author(s)
      沼口靖
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      福岡マリンメッセ
    • Year and Date
      20080328-30
  • [Presentation] 医工連携研究の成果である細胞シートの虚血下肢血流改善効果について2008

    • Author(s)
      沼口靖
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      福岡マリンメッセ
    • Year and Date
      20080328-30
  • [Presentation] 虚血時血管新生におけるアンギオテンシンIIの役割2008

    • Author(s)
      沼口靖
    • Organizer
      第16回日本血管生物医学会
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2008-12-03
  • [Presentation] Ablation of Insulin-Regulated Aminopeptidase(IRAP/AT4R)Attenuates Lipid Accumulation and Plaque Rupture in ApoE Deficient Mice2008

    • Author(s)
      沼口靖
    • Organizer
      アメリカ心臓協会年次学会2008
    • Place of Presentation
      アメリカルイジアナ州ニューオリンズ市コンヴェンションセンター
    • Year and Date
      2008-11-08
  • [Presentation] 磁性ナノ微粒子を用いた間葉系幹細胞シートの下肢虚血治療への応用2008

    • Author(s)
      沼口靖
    • Organizer
      第32回日本鉄バイオサイエンス学会
    • Place of Presentation
      ウェデイングプラザアラスカ青森県
    • Year and Date
      2008-09-14
  • [Presentation] Ablation of AngiotensinIV Receptor Attenuates Hypofibrinolysis via PAI-1Downregulation and Reduces Thromboembolism in Injured Arteries2008

    • Author(s)
      沼口靖
    • Organizer
      ATVB Conference2008
    • Place of Presentation
      CNNセンターアトランタ
    • Year and Date
      2008-04-17

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Published: 2010-06-10   Modified: 2016-04-21  

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