Development of novel methods to diagnose cardiovascular diseases with synchrotron radiation in SPring-8

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590817
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kobe University
• Principal Investigator: YAMASHITA Tomoya Kobe University, 医学部附属病院, 助教 (90437468)
• Project Period (FY): 2007 – 2008
• Keywords: 心臓病態学 / 血管病態学

Research Abstract

放射光を利用して、循環器疾患の診断に使用できる方法の開発を目指して研究を進めた。動脈硬化不安定粥腫の診断を目標に、位相差X線CTを共同で開発し、動物での撮影に成功し、動脈硬化の質的診断にまで到達した。また、X線回折法にての心筋症の新規診断方法を確率するための動物実験とヒトサンプルでの研究を進めた。

Research Products

• [Journal Article] Plasma tetrahydrobiopterin /dihydrobiopterin ratio (2009)
  • Author(s): Takeda M, Yamashita T, Shinohara M, Sasaki N, Takaya T, Nakajima K, Inoue N, Masano T, Tawa H, Satomi-Kobayashi S, Toh R, Sugiyama D, Nishimura K, Yokoyama M, Hirata K, Kawashima S.
  • Journal Title: Circ J. 73 Pages: 955-62
  • Peer Reviewed
• [Journal Article] Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats (2008)
  • Author(s): Masano T, Kawashima S, Toh R, Satomi-Kobayashi S, Shinohara M, Takaya T, Sasaki N Tawa H, Yamashita T, Yokoyama M, Hirata K
  • Journal Title: Circ J. 72 Pages: 1512-1519
  • Peer Reviewed
• [Journal Article] Augmentation of vascular remodeling by uncouled endothelial nitric oxide synthase in a mouse model of diabetes mellitus (2008)
  • Author(s): Sasaki N, Yamashita T, Takaya T, Shinohara M, Shiraki R, Takeda M, Emoto N, Fukatsu A, Hayashi T, Ikemoto K, Nomura T, Yokoyama M, Hirata K, Kawashima S.
  • Journal Title: Arterioscler Thromb Vase Biol. 28 Pages: 1068-1076
  • Peer Reviewed
• [Journal Article] Atherosclerotic Plaque Imaging using Phase-contrast X-ray Computed Tomography (2008)
  • Author(s): Shinohara M, Yamashita T, Tawa H, Takeda M, Sasaki N, Takaya T, Toh R, Takeuchi, A, Ohigashi T, Shinohara K, Yokoyama M, Kawashima S, Hirata K, Momose A.
  • Journal Title: Am J Physiol. 294 Pages: 1094-1100
  • Peer Reviewed
• [Journal Article] Local overexpression of Toll-like Receptors at the vessel wall induces formation of atherosclerotic lesion: Synergism of Toll-like Receptor 2 and Toll-like Receptor 4 (2007)
  • Author(s): Shinohara M, Hirata K, Yamashita T, Takaya T, Sasaki N, Shiraki R, Ueyama T, Emoto N, Inoue N, Yokoyama M, Kawashima S.
  • Journal Title: Arterioscler Thromb Vase Biol. 27 Pages: 2384-2391
  • Peer Reviewed
• [Journal Article] Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knoxkout mice (2007)
  • Author(s): Yamashita T, Kawashima S, Hirase T, Shinohara M, Takaya T, Sasaki N, Takeda M, Tawa H, Inoue N, Hirata K, Yokoyama M.
  • Journal Title: Am J Physiol. 293 Pages: C865-873
  • Peer Reviewed
• [Journal Article] Central Role of Calcium-Dependent Tyrosine Kinase PYK2 in Endothelial Nitric Oxide Synthase Mediated Angiogenic Response and Vascular Function (2007)
  • Author(s): Matsui A, Okigaki M, Amano K, Adachi Y, Jin D, Takai S, Yamashita T, Kawashima S, Kurihara T, Miyazaki M, Tateishi K, Matsunaga S, Katsume A, Honsho S, Takahashi T, Matoba S, Kusaba T, Tatsumi T, Matsubara H.
  • Journal Title: Circulation 116 Pages: 1041-1051
  • Peer Reviewed
• [Journal Article] A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression (2007)
  • Author(s): Takaya T, Hirata K, Yamashita T, Shinohara M, Sasaki N, Inoue N, Yada T, Goto M, Fukatsu A, Hayashi T, Alp NJ, Channon KM, Yokoyama M, Kawashima S.
  • Journal Title: Arterioscler Thromb Vase Biol. 27 Pages: 1632-37
  • Peer Reviewed
• [Presentation] Atheroscletoric Plaque Imaging using Phase-contrast X-ray Computed Tomography (2007)
  • Author(s): Yamashita T
  • Organizer: Orland FL, USA American Heart asociateion, Scientific Seesion
  • Year and Date: 20071104-07