Study of new therapy for heart failure

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Saga University
• Principal Investigator: NODE Koichi Saga University, 医学部, 教授 (80359950)
• Co-Investigator(Kenkyū-buntansha): INOUE Teruo 佐賀大学, 医学部, 准教授 (20168454) ; HIRASE Tetsuaki 佐賀大学, 医学部, 助教 (60363446)
• Project Period (FY): 2007 – 2008
• Keywords: 心不全 / 動脈硬化 / 高脂血症

Research Abstract

慢性心不全は新しい介入方法が期待されているが、今回の研究では日本人での慢性心不全に対するスタチン療法の前向き介入試験を企画した。24ヶ月間の試験期間、1次エンドポイントを心不全要化による入院または心臓死とした。合計570例の登録症例数、平均年齢63歳、NIHA IIが90%、IIIが10%、非虚血性心疾患が71%であった。2010年6月で最終評価を行う予定である。

Research Products

• [Journal Article] Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes (2008)
  • Author(s): Nishimura Y, Inoue T, Morooka T, Node K.
  • Journal Title: Circ J 72(4) Pages: 647-53
  • Peer Reviewed
• [Journal Article] Pentraxin3 is a novel marker for stent-induced inflammation and neointimal thickening (2008)
  • Author(s): Kotooka N, Inoue T, Fujimatsu D, Morooka T, Hashimoto S, Hikichi Y, Uchida T, Sugiyama A, Node K.
  • Journal Title: Atherosclerosis 197(1) Pages: 368-74
  • Peer Reviewed
• [Journal Article] Long-term effect of atorvastat in on neurohumoral activation and cardiac function in patients with chronic heart failure : a prospective randomized controlled study (2007)
  • Author(s): Yamada T, Node K, Mine T, Morita T, Kioka H, Tsukamoto Y, Tamaki S, Masuda M, Okuda K, Fukunami M.
  • Journal Title: Am Heart J 153(6) Pages: 1055.el-8
  • Peer Reviewed
• [Journal Article] Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometry (2007)
  • Author(s): Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.
  • Journal Title: Anal Biochem 362(1) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Effects of statins on restenosis after coronary stent implantation (2007)
  • Author(s): Kamishirado H, Inoue T, Sakuma M, Tsuda T, Hayashi T, Takayanagi K, Node K.
  • Journal Title: Angiology 58(1) Pages: 55-60
  • Peer Reviewed
• [Journal Article] Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure (2007)
  • Author(s): Hu R, Li G, Kamijo Y, Aoyama T, Nakajima T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.
  • Journal Title: Glycoconj J 24(9) Pages: 565-71
  • Peer Reviewed
• [Journal Article] Remnant-like lipoprotein particle level and insulin resistance are associated with in-stent restenosis in patients with stable angina (2007)
  • Author(s): Kato T, Inoue T, Inagaki H, Hashimoto S, Hikichi Y, Tanaka A, Isobe M, Node K.
  • Journal Title: Coron Artery Dis 18(4) Pages: 319-22
• [Journal Article] Impaired glucose tolerance : a possible contributor to left ventricular hypertrophy and diastolic dysfunction (2007)
  • Author(s): Fujita M, Asanuma H, Kim J, Liao Y, Hirata A, Tsukamoto O, Minamino T, Hori M, Goto M, Node K, Kitakaze H.
  • Journal Title: Int J Cardiol 118(1) Pages: 76-80
• [Presentation] Effect of Statin Administration Before Reperfusion Infarction (2008)
  • Author(s): Fujimatsu D, Hikichi Y, Hashimoto S, Nakamura I, Matsushita T, Kotooka N, Shimomura M, Shibata Y, Kawasaki T, Yamamoto Y, Inoue T, Node K.
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-29
• [Book] 高血圧ナビゲーター第2版 (2008)
  • Author(s): 小松愛子、野出孝一
  • Total Pages: 280-281
  • Publisher: ARBとスタチン