Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590833
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: HONGO Kenichi Jikei University School of Medicine, 医学部, 准教授 (00256447)
• Co-Investigator(Kenkyū-buntansha): KAWAI Makoto 東京慈恵会医科大学, 医学部, 講師 (40277025) ; KOMUKAI Kimiaki 東京慈恵会医科大学, 医学部, 講師 (60360145) ; OTSU Kinya 大阪大学, 大学院・医学系研究科, 准教授 (20294051)
• Project Period (FY): 2007 – 2009
• Keywords: 心臓病態学

Research Abstract

Regulation of intracellular Ca concentration (Ca^<2+>) is important for cardiac contraction. Especially, modulation of sarcoplasmic reticulum (Ca^<2+> store) function has a significant role on cardiac contractility. Selective up-regulation of sarcoplasmic reticulum function improved cardiac function during acidosis (important factor of cardiac dysfunction during ischemia). Ca^<2+> leak from sarcoplasmic reticulum is identified as another important determinant of cardiac function.

Research Products

• [Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current during endothelin-1 stimulation. (2010)
  • Author(s): Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
  • Journal Title: Am J Physiol Heart Circ Physiol (in press)
  • Peer Reviewed
• [Journal Article] Caと平滑筋収縮の関係(CaシグナルとRhoキナーゼ系を含めて) (2010)
  • Author(s): 本郷賢一
  • Journal Title: Modern Physician 30巻 Pages: 343-345
• [Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart. (2009)
  • Author(s): Morimoto S, O-Uchi J, Kawai M, Hoshina T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S
  • Journal Title: Biochem Biophys Res Commun 390(1) Pages: 87-92
  • Peer Reviewed
• [Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy (2009)
  • Author(s): Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M
  • Journal Title: in renovascular hypertensive rats. Hypertens Res 32(7) Pages: 604-610
  • Peer Reviewed
• [Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction. (2008)
  • Author(s): Komukai K, Yagi H, Ogawa T, Date T, Morimoto S, Kawai M, Hongo K, Taniguchi I, Yoshimura M
  • Journal Title: Circ J 72(12) Pages: 2004-2008
  • Peer Reviewed
• [Journal Article] Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure. (2008)
  • Author(s): Komukai K, Ogawa T, Yagi H, Date T, Sakamoto H, Kanzaki Y, Shibayama K, Hashimoto K, Inada K, Minai K, Ogawa K, Kosuga T, Kawai M, Hongo K, Taniguchi I, Yoshimura M
  • Journal Title: Circ J 72(7) Pages: 1152-1157
  • Peer Reviewed
• [Journal Article] Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. (2008)
  • Author(s): O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S
  • Journal Title: Circ Res 102(11) Pages: 1378-1388
  • Peer Reviewed
• [Journal Article] 心血管疾患のバイオマーカー最前線 (2008)
  • Author(s): 本郷賢一、吉村道博
  • Journal Title: 日本内科学会雑誌 137巻 Pages: S327-S328
• [Journal Article] Renal insufficiency is related to painless myocardial infarction. (2007)
  • Author(s): Komukai K, Ogawa T, Yagi H, Date T, Suzuki K, Sakamoto H, Miyazaki H, Takatsuka H, Shibayama K, Ogawa K, Kanzaki Y, Kosuga T, Kawai M, Hongo K, Yoshida S, Taniguchi I, Mochizuki S
  • Journal Title: Circ J 71(9) Pages: 1366-1369
  • Peer Reviewed
• [Journal Article] カルシウム拮抗薬の心保護作用
  • Author(s): 本郷賢一、吉村道博
  • Journal Title: CLINICAL CALCIUM 20巻 Pages: 89-93
• [Presentation] Endothelin-1 Increases L-type Ca Current of Rat Ventricular Myocytes via an Activation of Protein Kinase C and Ca/calmodulin Dependent Protein Kinase II. (2009)
  • Author(s): Komukai K, O-Uchi J, Hongo K, Kawai K, Morimoto S, Yoshimura M, Kurihara S
  • Organizer: AHA Scientific Sessions
  • Place of Presentation: Orlando USA
  • Year and Date: 20091100
• [Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mouse. (2009)
  • Author(s): Hongo K, Morimoto S, O-Uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
  • Organizer: XXXVIth International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 20090700
• [Presentation] β-adrenoceptor stimulation increased Ca leak from sarcoplasmic reticulum without dissociation of FKBP12. 6 under physiological condition. (2009)
  • Author(s): Morimoto S, O-Uchi J, Kawai M, Komukai K, Sasaki H, Yoshimura M, Hongo K, Kurihara S
  • Organizer: XXXVIth International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 20090700
• [Presentation] Cardiacα1A-adrenoceptor stimulation inhibits L-type Ca2+ current in the presence ofβ-adrenoceptor stimulation through tyrosine kinase. (2009)
  • Author(s): O-Uchi J, Komukai K, Morimoto S, Hongo K, Kurihara S
  • Organizer: Biophysical Society 53rd Annual Meeting
  • Place of Presentation: Boston USA
  • Year and Date: 20090200
• [Presentation] Decreased Ca2+ sensitivity of the myofilament is critical for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy. (2008)
  • Author(s): Hongo K, Morimoto S, Komukai K, Kawai M, O-Uchi J, Yoshimura M, Kurihara S
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080300
• [Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin-dependent protein kinase II in rat ventricular myocytes. (2008)
  • Author(s): Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080300
• [Presentation] β-adrenoceptor stimulation accelerates Ca2+ turnover through PKA-dependent phosphorylation in saponin-treated mouse myocardium. (2008)
  • Author(s): Morimoto S, O-Uchi J, Kawai M, Komukai K, Hongo K, Sasaki H, Kurihara S
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 20080300