Carddiac remodeling therapy due to induced expression by cardiac adiponectin

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: KANDA Tugiyasu Kanazawa Medical University, 医学部, 教授 (40261838)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Kenji 金沢医科大学, 医学部, 助教 (90340009)
• Project Period (FY): 2007 – 2008
• Keywords: サイトカイン / 心不全 / 再生医療 / 心筋炎

Research Abstract

アディポネクチンは脂肪細胞から分泌され、抗動脈硬化作用、抗炎症作用を持つサイトカインである。心筋傷害に伴う線維化が心筋内アディポネクチン発現増強に伴い減少している結果をマウス心筋炎モデルで見い出した。
さらに、心不全マウスモデルで、傷害心筋のアディポネクチン発現亢進を認めた。心不全や心肥大で抑制された心筋内アディポネクチンの発現を誘導することが、心筋再生治療の効果を高めることが明らかとなった。

Research Products

• [Journal Article] Silent information regulator, Sirtuin 1, and age-related diseases. (2009)
  • Author(s): Zeng L, Chen R, Liang F, Tsuchiya H, Murai H, Nakahashi T, Iwai K, Takahashi T, Kanda T, Morimoto S.
  • Journal Title: Geriatr Gerontol Int. 9(1) Pages: 7-15
  • Peer Reviewed
• [Journal Article] Chronic fatigue syndrome and the central nervous system. (2008)
  • Author(s): Chen R, Liang FX, Moriya J, Yamakawa J, Sumino H, Kanda T, Takahashi T .
  • Journal Title: J Int Med Res. 36(5) Pages: 867-74
  • Peer Reviewed
• [Journal Article] Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats. (2008)
  • Author(s): Iwai K, Takahashi T, Nakahashi T, Nomura K, Atsumi M, Zeng L, Ishigami K, Kanda T, Yamaguchi N, Morimoto S.
  • Journal Title: Hypertens Res. 31(5) Pages: 977-86
  • Peer Reviewed
• [Journal Article] Brain Atrophy in a Murine Model of Chronic Fatigue Syndrome and Beneficial Effect of Hochu-ekki-to (TJ-41). (2008)
  • Author(s): Chen R, Moriya J, Yamakawa JI, Takahashi T, Li Q, Morimoto S, Iwai K, Sumino H, Yamaguchi N, Kanda T.
  • Journal Title: Neurochem Res. 33(9) Pages: 1759-67
  • Peer Reviewed
• [Journal Article] Traditional Chinese Medicine for Chronic Fatigue Syndrome. (2008)
  • Author(s): Chen R, Moriya J, Yamakawa JI, Takahashi T, Kanda T.
  • Journal Title: Evid Based Complement Alternat Med.
  • Peer Reviewed
• [Presentation] Candesartan regulates polarization of Th1 and Th2 cytokines in lymphoid organs of obese mice with acute myocarditis (2008)
  • Author(s): T Kanda
  • Organizer: アメリカ心臓病学会 基礎心血管科学カンファランス
  • Place of Presentation: アメリカ合衆国コロラド州キーストーン
  • Year and Date: 2008-07-21