2008 Fiscal Year Final Research Report
Establishment and clinical application of new assay method for human chymase
| Project/Area Number |
19590841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
URATA Hidenori Fukuoka University, 筑紫病院, 教授 (30289524)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 心臓病態学 |
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| Research Abstract |
まず第一に、特異性の高いキマーゼ阻害薬を使用し、新しいヒトキマーゼ依存性アンジオテンシンII(AII)産生能の測定法を確立した。この方法を用いて、人の末梢血検体を分析し、ヒトキマーゼAII産生能がヒトの循環単核球中に存在し、単球に多く、男性で高値であり、白血球数・CRP、HOMA指数・尿中微量アルブミン/クレアチニン比などと正相関することを見出した。すなわち、生活習慣病の病態で循環単核球中のキマーゼ活性が増加することを明らかにした。
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Research Products
(18 results)
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[Journal Article] Antiarrhythmogenic Effect of Reconstituted High-Density Lipoprotein Against Ischemia/Reperfusion in Rats2008
Author(s)
Imaizmi S, Miura S, Nakamura K, Kiya Y, Uehara Y, Bo Zhang, Matsuo Y, Urata H, Ideishi M, Kerry-Anne Rye, Sata M, Saku K.
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Journal Title
Journal of the American College of Cardiology 51
Pages: 1604-1612
Peer Reviewed
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[Journal Article] Results of provisional stenting with a Sirolimus-eluting stent for bifurcation lesion : Multicenter study in Japan2008
Author(s)
Yanagi D, Shirai K, Takayama Y, Fukada Y, Kuwano T, Ike A, Mori K, Kubota K, Iwata A, Fujimi K, Kawamura A, Nishikawa H, Nathan Millerb, Bo Zhang, Tsuchiya Y, Urata H, Saku K.
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Journal Title
Journal of Cardiology 51
Pages: 89-94
Peer Reviewed
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[Presentation] Chymase Dependent Angiotensin II-Forming Activity in the Circulating Mononuclear Leukocyte Increases Post Acute Myocardial Infarction2009
Author(s)
Okamura K, Inoue Y, Uehara Y, Maruyama S, Sumi S, Furuyama S, Kodama S, Andoh C, Niimura H, Tohjoh H, Miyoshi K, Miura S, Yamanouchi Y, Saku K, Urata H.
Organizer
第73回日本循環器学会総会・学術集会
Year and Date
2009-03-21
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[Presentation] High chymase activity in the circulating mononuclear leukocyte is related to high c-reactive protein and insulin levels2008
Author(s)
Okamura k, Inoue Y, Uehara Y, Sumi S, Kudo K, Kodama S, Ando C, Mihara H, Niimura H, Miyoshi K, Tsuchiya Y, Miura S, Yamanouchi Y, Saku K, Urata H.
Organizer
ISH2008
Year and Date
2008-06-16
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[Presentation] High chymase activity in the circulating mononuclear leukocyte is related to high c-reactive protein and insulin levels2008
Author(s)
Okamura K, Inoue Y, Uehara Y, Abe S, Sumi S, Kudo K, Kodama S, Ando C, Mihara H, Niimura H, Miyoshi K, Tsuchiya Y, Miura S, Yamanouchi Y, Saku K, Urata H.
Organizer
第72回日本循環器学会総会・学術集会
Year and Date
2008-03-29
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