The mechanisms of the inhibitory effect of G-CSF on the progression of atherosclerosis

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590851
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Chiba University
• Principal Investigator: HASEGAWA Hiroshi Chiba University, 大学院・医学研究院, 助教 (50375656)
• Co-Investigator(Kenkyū-buntansha): TAKANO Hiroyuki 千葉大学, 医学部・附属病院循環器内科, 講師 (60334190)
• Project Period (FY): 2007 – 2008
• Keywords: 動脈硬化 / G-CSF / サイトカイン治療 / 内皮障害

Research Abstract

造血性サイトカインであるG-CSFは心筋保護作用を有し, 新規心筋梗塞治療薬として期待しうることを, 既に我々は報告している。一方, 心筋梗塞患者は動脈硬化を合併している可能性が高いことから, G-CSFによる動脈効果に対する作用について検討した。G-CSFは動脈硬化進展抑制作用を要することがウサギおよびマウス動脈硬化モデルにおいて認められたため, そのメカニズムについて, 主に免疫・炎症系の関与について焦点を当てて, 遺伝子改変マウスモデルを用いて詳細に検証した。

Research Products

• [Journal Article] Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111 In Fab fragment of monoclonal antibody specific for tenascin-C (2008)
  • Author(s): Odaka K, Uehara T, Arano Y, Adachi S, Tadokoro H, Yoshida K, Hasegawa H, Imanaka-Yoshida K, Yoshida T, Hiroe M, Irie T, Tanada S, Komuro I
  • Journal Title: Int Heart J. 49 Pages: 481-492
  • Peer Reviewed
• [Journal Article] 虚血性心疾患に対するサイトカイン治療 (2008)
  • Author(s): 長谷川洋, 小室一成
  • Journal Title: 総合臨床 Vol.57, No.2 Pages: 236-241
• [Journal Article] サイトカインによる急性心筋梗塞治療は有用か? (2008)
  • Author(s): 高野博之
  • Journal Title: 専門医のための薬物療法Q & A循環器 166
• [Journal Article] 急性心筋梗塞に対するG-CSF治療ICUとCCU (2008)
  • Author(s): 高野博之
  • Journal Title: 31 Pages: 823-832
• [Journal Article] 造血性サイトカイン(G-CSF)による心筋梗塞治療Medical View Point (2008)
  • Author(s): 高野博之
  • Journal Title: 29 Pages: 5
• [Journal Article] 急性心筋梗塞に対するG-CSF治療の臨床研究-現状と問題点Annual Review (2008)
  • Author(s): 高野博之、小室一成
  • Journal Title: 循環器 Pages: 136-143
• [Journal Article] Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction (2007)
  • Author(s): Takano H, Hasegawa H, Kuwabara Y, Nakayama T, Matsuno K, Miyazaki Y, Yamamoto M, Fujimoto Y, Okada H, Okubo S, Fujita M, Shindo S, Kobayashi Y, Komiyama N, Takekoshi N, Imai K, Himi T, Ishibashi I, Komuro I
  • Journal Title: Int. J. Cardiol. 122 Pages: 41-7
  • Peer Reviewed
• [Journal Article] G-CSF therapy for acute myocardial infarction (2007)
  • Author(s): Takano H, Ueda K, Hasegawa H, Komuro I
  • Journal Title: Trends Pharmacol Sci. 28 Pages: 512-7
  • Peer Reviewed
• [Presentation] G-CSF therapy for acute myocardial infarction : From animal experiments to clinical trials. (2008)
  • Author(s): Hiroyuki Takano, Issei Komuro
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Myocardial Protection Strategy after Reperfusion Therapy in Acute Coronary Syndrome Cytokine therapy for myocardial infarction-G-CSF and erythropoietin- (2008)
  • Author(s): Hiroshi Hasegawa, Hiroyuki Takano, Kazutaka Ueda, Raita Uchiyama, Issei Komuro
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080328-30
• [Presentation] Acute care for cardiovascular ischemia (2008)
  • Author(s): Hiroshi Hasegawa, Issei Komuro
  • Organizer: International Conference of Geriatric Emergency & Critical Care 2008 5th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences
  • Place of Presentation: Taipei
  • Year and Date: 2008-12-13
• [Presentation] Erythropoietin prevents cardiac remodeling after myocardial infarction through erythropoietin receptor-induced signaling pathways in cardiomyocytes (2008)
  • Author(s): Kazutaka Ueda, Hiroyuki Takano, Yuriko Niitsuma, Hiroshi Hasegawa, Raita Uchiyama, Issei Komuro
  • Organizer: International Conference of Geriatric Emergency & Critical Care(Keystone, CO)
  • Place of Presentation: Taipei
  • Year and Date: 2008-12-13
• [Presentation] Erythropoietin promotes angiogenesis and prevents heart failure after myocardial infarction (2008)
  • Author(s): Raita Uchiyama, Hiroyuki Takano, Kazutaka Ueda, Yuriko Niitsuma, Hiroshi Hasegawa, Issei Komuro
  • Organizer: International Conference of Geriatric Emergency & Critical Care(Keystone, CO)
  • Place of Presentation: Taipei
  • Year and Date: 2008-12-13
• [Presentation] Erythropoietin prevents cardiac remodeling after myocardial infarction through erythropoietin receptor-induced signaling pathways in cardiomyocytes
  • Author(s): Kazutaka Ueda, Hiroyuki Takano, Yuriko Niitsuma, Hiroshi Hasegawa, Raita Uchiyama, Issei Komuro
  • Organizer: 2007 Annual Symposium of the American Heart Association scientific sessions
  • Place of Presentation: Orlando, FL