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2008 Fiscal Year Final Research Report

Establishement of a novel anti-tumor therapy utilizing inhibition of angiogenesis

Research Project

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Project/Area Number 19590862
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKobe University

Principal Investigator

ISHIDA Tatsuro  Kobe University, 大学院医学研究科, 助教 (00379413)

Project Period (FY) 2007 – 2008
Keywords(1) 血管内皮 / (2) 血管新生 / (3)末梢血管 / (4) 循環器 / (5) 接着分子
Research Abstract

生体内で血管内皮特異的接着分子(ESAM)の機能を阻害することによって腫瘍血管新生が阻害され、結果として腫瘍の成長が抑制されるかどうかを検討した。野生型およびESAM欠損マウスに悪性黒色種細胞を静脈内播種したところ、ESAM欠損マウスでは、有意に肺への腫瘍転移と腫瘍血管の発育が抑制されていた。培養内皮細胞におけるESAM発現は細胞の遊走能と管腔形成能と相関した。以上より、血管に富む腫瘍ではESAMを介する内皮の遊走と管腔形成によって腫瘍血管が増生し、その結果、腫瘍が血管依存的に増大することが示された。

  • Research Products

    (17 results)

All 2009 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) Book (4 results)

  • [Journal Article] RAGE mediates oxidized LDL-induced pro-inflammatory actions and atherosclerosis in non-diabetic LDL receptor-deficient mice2009

    • Author(s)
      Sun L, Ishida T, Yasuda T, Kuriyama M, Kojima Y, Yamamoto Y, Yamamoto H, Ishibashi S, Hirata K, Hayashi K
    • Journal Title

      Cardiovasc Res 82(2)

      Pages: 371-81

    • Peer Reviewed
  • [Journal Article] Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy2009

    • Author(s)
      Hara T, Ishida T, Cangara HM, Hirata K
    • Journal Title

      Microvasc Res 77(3)

      Pages: 348-55

    • Peer Reviewed
  • [Journal Article] Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration2009

    • Author(s)
      Otera H, Ishida T, Nishiuma T, Kobayashi K, Kotani K, Yasuda T, Kundu RK, Quertermous T, Hirata K, Nishimura Y
    • Journal Title

      American Journal of Physiology-Lung Cellular and Molecular Physiology 296(4)

      Pages: L594-602

    • Peer Reviewed
  • [Journal Article] The Adhesion Molecule ESAM1 is A Novel Hematopoietic Stem Cell Marker. Stem Cells2008

    • Author(s)
      Ooi AG, Karsunky H, Majeti R, Butz S, Vestweber D, Ishida T, Quertermous T, Weissman IL, Forsberg EC
    • Pages
      0
    • Peer Reviewed
  • [Journal Article] Serotonin induces vasoconstriction of smooth muscle cell-rich neointima though 5-hydroxytryptamine2A receptor in rabbit femoral arteries2008

    • Author(s)
      Nishihira K, Yamashita A, Tanaka N, Moriguchi-Goto S, Imamura T, Ishida T, Kawashima S, Yamamoto R, Kitamura K, Asada Y
    • Journal Title

      J Thromb Haemost 6

      Pages: 1207-1214

    • Peer Reviewed
  • [Journal Article] Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages2007

    • Author(s)
      Yasuda T, Hirata K,Ishida T, Kojima Y, Tanaka H, Okada T, Quertermous T, Yokoyama M
    • Journal Title

      J Atheroscler Thromb 14(4)

      Pages: 192-201

    • Peer Reviewed
  • [Journal Article] Role of endothelial lipase in low HDL levels in a murine model of hypertriglyceridemia

    • Author(s)
      Tanaka H, Ishida T, Johnston TP, Kojima Y, Yasuda T, Kundu RK, Quertermous T, Hirata K
    • Journal Title

      J Atheroscler Thromb

      Pages: 0

    • Peer Reviewed
  • [Presentation] Targetd inactivation of receptor for advanced glycation products reduced oxidative LDL-induced inflammation and atherosclerosis in non-diabetic LDL receptor-/- mice2008

    • Author(s)
      Sun L, Ishida T, Kuriyama M, Yasuda T, Hara T, Hirata K, Hayashi Y
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2008-11-11
  • [Presentation] Hirata K. Role of endothelial cell-selective adhesion molecule in the progression of atherosclerosis2008

    • Author(s)
      Inoue M, Ishida T, Hara T, Cangara H, Sun L
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2008-11-10
  • [Presentation] 動脈硬化形成過程におけるendothelial cell-selective adhesion molecule (ESAM)の役割について2008

    • Author(s)
      井上通彦、石田達郎、原哲也、平田健一
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-07-10
  • [Presentation] Role of endothelial cell-selective adhesion molecule (ESAM) in tumor angiogenesis and metastasis2008

    • Author(s)
      Cangara H, Ishida T, Kuriyama M, Hara T, Inoue M, Yasuda T, Hayashi Y, Hirata K
    • Organizer
      第72回 日本循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
  • [Presentation] RAGE Deficiency Inhibit the Atherosclerosis Progression in non diabetic Low-Density Lipoprotein Receptor Knockout Mice2008

    • Author(s)
      LiS, Ishida T, Kuriyama M, Yasuda T, Hara T, Hayashi Y, Hirata K
    • Organizer
      第72回 日本循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
  • [Presentation] High Glucose Stimulation Reduced Endothelial Cell-Selective Adhesion Molecule (ESAM) Expression : A Potential Role in Albuminuria in Diabetic Microangiopathy2008

    • Author(s)
      Hara T, Ishida T, Yasuda T, Okada T, Fukuda A, Inoue M, Kureha F, Hirata K
    • Organizer
      第72回 日本 循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
  • [Book] 先端医学社「JELIS」2009

    • Author(s)
      石田達郎、平田健一
    • Total Pages
      354-355
    • Publisher
      先端医学社
  • [Book] 新・心臓病診療プラクティスシリーズ12 冠動脈疾患の病態に迫る「高LDLコレステロール血症/低HDLコレステロール血症の関与」2008

    • Author(s)
      石田達郎、平田健一
    • Total Pages
      40-46
    • Publisher
      文光堂
  • [Book] β遮断薬のすべて 第3版. 「β遮断薬の血管・血管内皮に対する作用」2008

    • Author(s)
      原哲也、石田達郎、平田健一
    • Total Pages
      95-100
    • Publisher
      先端医学社
  • [Book] 循環器疾患最新の治療2008-2009 「冠動脈疾患と抗血小板療法」2008

    • Author(s)
      石田達郎、横山光宏
    • Total Pages
      99-102
    • Publisher
      南江堂

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Published: 2010-06-10   Modified: 2016-04-21  

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