2009 Fiscal Year Final Research Report
A novel function of membrane cholesterol transporter and a therapeutic strategy for atherosclerosis
| Project/Area Number |
19590874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
UEHARA Yoshinari Fukuoka University, 医学部, 講師 (70373149)
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| Co-Investigator(Kenkyū-buntansha) |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
MATSUNAGA Yoichi 徳島文理大学, 薬学部, 教授 (80239053)
YAMADA Tatsuo 福岡大学, 医学部, 教授 (60159217)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脂質 / 循環器・高血圧 / 高比重リポ蛋白 / 発現制御 / 遺伝子多型 / リポ蛋白 / アポリポ蛋白 |
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| Research Abstract |
A novel -257T>G single nucleotide polymorphism (SNP) was found in ATP-Binding Cassette Transporter (ABC) G1 promoter. The -257T>G SNP had a reduced transcriptional activity of ABCG1 invitro. In the clinical analysis of ABCG1 -257T>G SNP, although ABCG1 was not related with plasma cholesterol levels, it was shown that ABCG1 had affected to a lipoprotein composition such as HDL prticle in patients with ischemic heart disease. This is a new finding to show that ABCG1 contributes to protect a progression of atherosclerosis.
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