2008 Fiscal Year Final Research Report
Study of genetic contribution to the development of emphysema
| Project/Area Number |
19590887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
HANAOKA Masayuki Shinshu University, 医学部, 准教授 (20334899)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Keisaku 信州大学, 医学部, 教授 (70242691)
OTA Masao 信州大学, 医学部, 講師 (50115333)
URUSHIHATA Kazuhisa 信州大学, 医学部・附属病院, 助教 (60362125)
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| Research Collaborator |
ITO Michiko 信州大学, 医学部・附属病院, 診療助教
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| Project Period (FY) |
2007 – 2008
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| Keywords | COPD / 肺気腫 / 呼吸機能 / 遺伝子多型 / PCR / TGF-ss1 / Toll-like receptor 4 |
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| Research Abstract |
慢性閉塞性肺疾患(COPD)は人口の高齢化が進むにつれ増加し、2020年には全世界の死亡原因の第3位になると予想されている。COPDの発症機序はいまだ不明であるが、全喫煙者のうち約15%が発症するという事実は、本症における遺伝的素因の存在を示唆する。本研究ではCOPDの臨床病型のうち日本人に頻度が高い肺気腫に焦点をあて、transforming growth factor beta1(TGF-ss1)遺伝子とToll-like receptor4(TLR4)遺伝子の多型を解析した。その結果、これら遺伝子の幾つかの一塩基多型(single nucleotide polymorphisms ; SNPs)が肺気腫と有意に関連することを見出した。
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Research Products
(34 results)
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[Journal Article] Selective IgM deficiency accompanied with IgG4 deficiency, dermal complications and a bronchial polyp2008
Author(s)
Ideura G, Agematsu K, Komatsu Y, Hatayama O, Yasuo M, Tsushima K, Hanaoka M, Koizumi T, Fujimoto K, Kubo K
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Journal Title
Allergol Int 57
Pages: 99-105
Peer Reviewed
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[Journal Article] Adaptation to high altitude in sherpas: association with the insertion/deletion polymorphism in the angiotensin-converting enzyme gene2008
Author(s)
Droma Y, Hanaoka M, Basnyat B, Arjyal A, Neupane P, Pandit A, Sharma D, Ito M, Miwa N, Katsuyama Y, Ota M, Kubo K
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Journal Title
Wilderness Environ Med 19
Pages: 22-9
Peer Reviewed
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[Journal Article] Pleomorphic adenoma with an endobronchial resection2008
Author(s)
Matsubara M, Yasuo M, Tanabe T, Tsushima K, Urushihata K, Yamamoto H, Hanaoka M, Koizumi T, Fujimoto K, Kubo K, Yamazaki Y, Uehara T
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Journal Title
Intern Med 47
Pages: 1117-20
Peer Reviewed
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[Journal Article] Mediastinal seminoma in a patient with multiple endocrine neoplasia type 12008
Author(s)
Tanabe T, Yasuo M, Tsushima K, Urushihata K, Yamamoto H, Hanaoka M, Koizumi T, Fujimoto K, Yamazaki Y, Hirose Y, Hamano H, Sakurai A, Kubo K
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Journal Title
Intern Med 47
Pages: 1615-9
Peer Reviewed
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[Presentation] Toll like receptor 4 gene polymorphisms and COPD in Japanese population2007
Author(s)
Ito M, Hanaoka M, Droma Y, Yasuo M, Tanabe T, Komatsu T, Katsuyama Y, Ota M, Fujimoto K, Kubo K
Organizer
American Thoracic Society International Conference
Place of Presentation
Toronto, May
Year and Date
20070000
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