Development of dendritic cell vaccine modified with a ligand of NKT cells against tuberculosis

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590888
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUDA Takafumi Hamamatsu University School of Medicine, 医学部, 助教 (30291397)
• Co-Investigator(Kenkyū-buntansha): NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024) ; CHIDA Kingo 浜松医科大学, 医学部, 准教授 (40197611)
• Project Period (FY): 2007 – 2008
• Keywords: 樹状細胞 / ワクチン / 結核

Research Abstract

未だ有効なワクチンがない結核菌を含む細胞内寄生菌感染症に対し、NKT細胞のリガンドであるαガラクトシルセラミドを用いて極めて強い感染防御能を誘導する樹状細胞ワクチンの開発に成功した。

Research Products

• [Journal Article] Mucosal Vaccine Using Cytotoxic T Cell Epitope-Pulsed Dendritic Cell Confers Protection for Intracellular Pathogen (2009)
  • Author(s): Ozawa Y, Suda T, et.al.
  • Journal Title: Am J Respir Cell Mol Biol (In press)
  • Peer Reviewed
• [Journal Article] Lung dendritic cells have a potent capability to induce production of immunoglobulin A (2008)
  • Author(s): Naito T, Suda T, et.al.
  • Journal Title: Am J Respir Cell Mol Biol 38 Pages: 161-167
  • Peer Reviewed
• [Journal Article] Intratracheal administration of third-generation lentivirus vector encoding MPT51 from Mycobacterium tuberculosis induces specific CD8+ T-cell responses in the lung (2008)
  • Author(s): Hashimoto D, Suda T, et.al.
  • Journal Title: Vaccine 26 Pages: 5095-5100
  • Peer Reviewed
• [Journal Article] Identification of an HLA-A*0201-restricted T-cell epitope on the MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis, by MPT51 overlapping peptide screening (2008)
  • Author(s): Aoshi T, Suda T, et.al.
  • Journal Title: Infect Immun 76 Pages: 1565-1571
  • Peer Reviewed
• [Journal Article] Chemokine receptor-mediated delivery of mycobacterial MPT51 protein efficiently induces antigen-specific T-cell responses (2008)
  • Author(s): Uchijima M, Nagata T, et.al.
  • Journal Title: Vaccine 26 Pages: 5165-5169
  • Peer Reviewed
• [Journal Article] In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium (2008)
  • Author(s): Nagata T, et.al.
  • Journal Title: Vaccine 26 Pages: 5123-5127
  • Peer Reviewed
• [Journal Article] Immunization with dendritic cells loaded with alpha-galactosylceramide at priming phase, but not at boosting phase, enhances cytotoxic T lymphocyte activity against infection by intracellular bacteria (2007)
  • Author(s): Enomoto N, Suda T, et.al.
  • Journal Title: FEMS Immunol Med .Microbiol 51 Pages: 350-362
  • Peer Reviewed