Lung regenerative medicine using fibroblasts-derived stem cell line with stem cell inducing factors

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagoya University
• Principal Investigator: HASHIMOTO Naozumi Nagoya University, 医学部・附属病院, 助教 (30378020)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Yoshinori 名古屋大学, 大学院・医学系研究科, 教授 (20270986)
• Project Period (FY): 2007 – 2008
• Keywords: 呼吸器病学 / 再生医療

Research Abstract

根治的な治療方法が確立されていない慢性閉塞性肺疾患(COPD)を始めとする多くの呼吸器疾患に対して肺構成細胞の再生治療は『既存の肺構造の破壊』に対する治療ストラテジーの一つとして重要な課題である。我々は線維芽細胞株と薬剤誘導遺伝子発現システムを組み合わせてinduced pluripotent stem (iPS)細胞の樹立を試み安定した細胞株の樹立と肺構成細胞の分化機序を検討した。

Research Products

• [Journal Article] Up-regulation of Surfactant Protein Production in a Mouse Model of Secondary Pulmonary Alveolar Proteinosis (2008)
  • Author(s): Shibasaki1 M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi1K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T
  • Journal Title: Am J Respir Cell Mol Biol (In press)
  • Peer Reviewed
• [Journal Article] Healthcare-associated pneumonia among hospitalized patients in a Japanese community hospital (2008)
  • Author(s): Shindo Y, Shinji Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, Imaizumi K, Sato T, Hasegawa Y
  • Journal Title: Chest (In press)
  • Peer Reviewed
• [Journal Article] TH1/TH2 immune response in lung fibroblasts in interstitial lung disease (2008)
  • Author(s): Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T
  • Journal Title: Arch Med Res 39 Pages: 503-510
  • Peer Reviewed
• [Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation (2008)
  • Author(s): Yokoyama T, Osada H, Murakami H, Tatematsu Y, Taniguchi T, Kondo Y, Yatabe Y, Hasegawa Y, Shimokata K, Horio Y, Hida T, Sekido Y
  • Journal Title: Carcinogenesis (In press)
  • Peer Reviewed
• [Journal Article] Dual pathway activated by tert-butyl hydroperoxide in human airway anion secretion (2008)
  • Author(s): Matsuno T, Ito Y, Ohashi T, Morise M, Takeda N, Shimokata K, Imaizumi K, Kume H, Hasegawa Y
  • Journal Title: J Pharmacol Exp Ther (In press)
  • Peer Reviewed
• [Journal Article] Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction (2008)
  • Author(s): Ito S, Kume H, Shiraki A, Kondo M, Makino Y, Kamiya K, Hasegawa Y
  • Journal Title: Pulm Pharmacol Ther 21 Pages: 812-817
  • Peer Reviewed
• [Journal Article] A phase II study of carboplatin and paclitacel with meloxicam (2008)
  • Author(s): Suzuki R, Yamamoto M, Saka H, Taniguchi H, Shindoh J, Tanikawa Y, Nomura F, Gonda H, Imaizumi K, Hasegawa Y, Shimokata K
  • Journal Title: Lung Cancer In press
  • Peer Reviewed