Establishment of personalized therapy with epidermal growth factor receptor inhibitors for lung cancer based on the inhibitory effects of surfactant secretion

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagasaki University
• Principal Investigator: SODA Hiroshi Nagasaki University, 大学院・医歯薬学総合研究科, 客員研究員 (60244042)
• Research Collaborator: NAKAMURA Yoichi 長崎大学, 病院, 助教 (20432974)
• Project Period (FY): 2007 – 2009
• Keywords: 肺癌 / 分子標的治療 / 個別化治療

Research Abstract

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have dramatic effects in selective patients with non-small cell lung cancer. A non-invasive method for predicting the efficacy of EGFR tyrosine kinase inhbitors is needed in clinical settings. The production of surfactant proteins is reported to be regulated through the EGF signaling pathway. The present study suggested that EGFR mutations in the tumor and high levels of serum surfactant protein-D before treatment may predict the efficacy of EGFR tyrosine kinase inhibitors.

Research Products

• [Journal Article] Interstitial pneumonia probably associated with sorafenib treatment: an alert of an adverse event (2010)
  • Author(s): Ide S Soda H, Hakariya T, Takemoto S, Ishimoto H, Tomari S, Sawai T, Nagashima S, Furukawa M, Nakamura Y, Kohno S
  • Journal Title: Lung Cancer 67 Pages: 248-250
  • Peer Reviewed
• [Journal Article] Gefitinib increases serum concentrations of oral irinotecan and SN-38 without increasing the biliary concentration of SN-38 in rats (2008)
  • Author(s): Nakamura Y, Stake K, Sano K, Ito A, Yoshikawa M, Ikegami Y, Yoshida H, Nakano H, Oka M, Sawada S, Soda H, Kohno S
  • Journal Title: Chemotherapy 54 Pages: 485-491
  • Peer Reviewed
• [Journal Article] Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: long-term follow-up of radiological findings (2008)
  • Author(s): Soda H, Nakamura Y, Nakatomi K, Tomonaga N, Yamaguchi H, Nakano H, Nagashima S, Anami M, Hayashi T, Tsukamoto K, Kohno S
  • Journal Title: Lung Cancer 60 Pages: 298-301
  • Peer Reviewed
• [Journal Article] Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule (2008)
  • Author(s): Nakano H, Soda H, Takasu M, Tomonaga N, Yamaguchi H, Nakatomi K, Fujino S, Hayashi T, Nakamura Y, Tsukamoto K, Kohno S
  • Journal Title: Lung Cance 60 Pages: 136-140
  • Peer Reviewed
• [Journal Article] Different epidermal growth factor receptor gene mutations in a patient with two synchronous lung cancers (2007)
  • Author(s): Nakano H, Soda H, Nakamura Y, Uchida K, Takasu M, Nakatomi K, Izumikawa K, Hayashi T, Nagayasu T, Tsukamoto K, Kohno S
  • Journal Title: Clin Lung Cancer 8 Pages: 562-564
  • Peer Reviewed
• [Journal Article] Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer
  • Author(s): Yamaguchi H, Soda H, Nakamura Y, Takasu M, Tomonaga N, Nakano H, Doi S, Nakatomi K, Nagashima S, Takatani H, Fukuda M, Hayashi T, Tsukamoto K, Kohno S
  • Journal Title: Cancer Chemother Pharmacol (in press)
  • Peer Reviewed
• [Presentation] シンポジウム:肺癌・胸膜中皮腫の治療戦略, 化学療法 (2009)
  • Author(s): 早田宏
  • Organizer: 第35回肺癌診断会(日本肺癌学会主催)
  • Place of Presentation: 長崎
  • Year and Date: 20090625-20090627
• [Presentation] 当院で経験した薬剤性肺障害の検討 (2009)
  • Author(s): 石本裕士, 坂本憲穂, 原信太郎, 井手昇太郎, 竹本慎之輔, 泊慎也, 長島聖二, 澤井豊光, 早田宏, , 迎寛, 河野茂
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 20090612-20090614
• [Presentation] ゲフィチニブ血中濃度の肺癌患者における抗腫瘍活性に与える影響EGFR遺伝子解析の追加報 (2008)
  • Author(s): 中村洋一, 佐野和美, 早田宏, 塚元和弘, 高谷洋長島聖二, 福田実, 山口博之, 土井誠志, 中富克己, 岡三喜男, 河野茂
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Gefitinib効果予測因子としての血清SP-Dの検討 (2008)
  • Author(s): 山口博之, 中村洋一, 朝永七枝, 中野浩文, 土井誠志, 中富克己, 早田宏, 塚元和弘, 河野茂
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] リンパ節転移巣において原発巣と異なるEGFR遺伝子変異を示した肺扁平上皮癌の一例 (2008)
  • Author(s): 朝永七枝, 山口博之, 中野浩文, 土井誠志, 中富克己, , 塚元和弘, 河野茂
  • Organizer: 第31回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20080613-20081614
• [Presentation] Gefitinib効果予測因子としての血清SP-Dの検討 (2007)
  • Author(s): 山口博之, 中村洋一, 朝永七枝, 中野浩文, 中富克己, 早田宏, 河野茂
  • Organizer: 第48回日本肺癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20071108-20071109
• [Presentation] 肺腺癌のEGFR変異とgefitinibによる治療効果との相関解析 (2007)
  • Author(s): 高巣峰代, 卜部奏, 小林奨, 中野浩文, 山口博之, 中富克己, 中村洋一, 橋口浩二, 福田正明, 福田実, 木下明敏, 岡三喜男, 河野茂, 塚元和弘
  • Organizer: 第48回日本肺癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20071108-20071109
• [Presentation] Pharmacokinetics of gefitinib predicts the antitumor activity for advanced non-small cell lung cancer (2007)
  • Author(s): Iida T, Nakamura Y, Fukuda M, Takatani H, Nagashima S, Kinoshita A, Fukuda M, Soda H
  • Organizer: 12th World Conference on Lung Cancer
  • Place of Presentation: Seoul
  • Year and Date: 20070902-20070906