2009 Fiscal Year Final Research Report
Significance of Wnt signaling in pleural mesothelioma
| Project/Area Number |
19590910
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
UEMATSU Kazutsugu Saitama Medical University, 医学部, 准教授 (10297880)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIYAMA Gaku 埼玉医科大学, 医学部, 助教 (30364798)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 胸膜中皮腫 / WNTシグナル / Dishevelled(Dvl) |
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| Research Abstract |
To clarify the effect of blocking Wnt signaling in mesothelioma, we down-regulated the expression of dishevelled (Dvl), an intermediator of Wnt signaling, by a small interfering RNA (siRNA). Mesothelioma cell lines were transfected with siRNA of Dvl, and cell growth was examined. The synergistic effect on cell growth of Dvl siRNA and cisplatin in combination was evaluated. Dvl siRNA down-regulated the expression of Dvl in mesothelioma cells, which caused suppression of cell growth. Combination of Dvl siRNA and cisplatin suppressed cell growth synergistically. Our data suggest that inhibition of Wnt signaling leads to significant anti-tumor effects.
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Research Products
(7 results)
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[Journal Article] Frequency of and variables associated with the EGFR mutation and its subtypes.2010
Author(s)
Tanaka T, Matsuoka M, Sutani A, Gemma A, Maemondo M, Inoue A, Okinaga S, Nagashima M, Oizumi S, Uematsu K, Nagai Y, Moriyama G, Miyazawa H, Ikebuchi K, Morita S, Kobayashi K, Hagiwara K.
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Journal Title
International Journal of Cancer 126
Pages: 651-655
Peer Reviewed
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[Journal Article] Reduced transcription of the Smad4 gene during pulmonary carcinogenesis in idiopathic pulmonary fibrosis.2009
Author(s)
Takenaka T, Gemma A, Yoshimura A, Hosoya Y, Nara M, Hosomi Y, Okano T, Kunugi S, Koizumi K, Fukuda Y, Uematsu K, Shimizu K, Kudoh S.
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Journal Title
Molecular Medicine Reports Vol.2
Pages: 73-80
Peer Reviewed
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[Journal Article] Tegafur-uracil plus gemcitabine combination chemotherapy in patients with advanced non-small cell lung cancer previously treated with platinum.2008
Author(s)
Seto T, Yamanaka T, Nakano M, Ota M, Maruyama R, Okamoto T, Wataya H, Uematsu K, Seki N, Eguchi K, Semba H, Ichinose Y.
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Journal Title
Journal of Thoracic Oncology Vol.3
Pages: 637-642
Peer Reviewed
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[Journal Article] Targeting the Wnt Signaling Pathway with Dishevelled and Cisplatin Synergistically Suppresses Mesothelioma Cell Growth.2007
Author(s)
Uematsu K, Seki N, Seto T, Isoe C, Tsukamoto H, Mikami I, You L, He B, Xu Z, Jablons DM, Eguchi K.
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Journal Title
Anticancer Research Vol.27
Pages: 4239-4242
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