2008 Fiscal Year Final Research Report
Screening of novel biomarkers and therapeutic targets in diabetic nephropathy
Project/Area Number |
19590949
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
SUGAHARA Akira Kyoto University, 医学研究科, 臨床教授 (00312223)
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Co-Investigator(Renkei-kenkyūsha) |
MORI Kiyoshi 京都大学, 医学研究科, 講師 (60343232)
SATOU Noriko 京都医療センター・臨床研究センター, 研究員 (80373512)
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Project Period (FY) |
2007 – 2008
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Keywords | 腎臓学 |
Research Abstract |
1型および2型糖尿病のマウスモデルを用いて、糖尿病性腎症の早期に発現増加が改善する遺伝子としてgremlin 1、growth arrest-specific 6、Wt-1、Rab3bなどを同定し、これらの因子の糖尿病性腎症への関与が示唆された。さらに糖尿病性腎症においては尿中Ngal が増加し、アンギオテンシン受容体阻害薬の投与により減少することを明らかにし、尿中Ngal の新規バイオマーカーとしての有用性を報告した。
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[Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons2009
Author(s)
Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Yoshioka T, Ogawa Y, Imamaki H, Kusakabe T, Ebihara K, Omata M, Satoh N, Sugawara A, Barasch J, Nakao K
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Journal Title
Kidney Int 75(3)
Pages: 285-94
Peer Reviewed
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[Journal Article] Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury2008
Author(s)
Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, Buchen C, Khan F, Mori K, Giglio J, Devarajan P, Barasch J
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Journal Title
Ann Intern Med 148(11)
Pages: 810-9
Peer Reviewed
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[Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis2008
Author(s)
Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
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Journal Title
Kidney Int 74(1)
Pages: 70-80
Peer Reviewed
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[Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice2008
Author(s)
Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, Yoshioka T, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K
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Journal Title
Kidney Int 73(4)
Pages: 446-55
Peer Reviewed
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[Journal Article] Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney2007
Author(s)
Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K
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Journal Title
Am J Physiol Renal Physiol 293(4)
Pages: 1363-72
Peer Reviewed
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[Presentation] Reduction of urinary excretion of neutrophil gelatinaseassociated lipocalin(Ngal)by angiotensin receptor blockers(ARBs)in diabetic or obese subjects2008
Author(s)
Kuwabara T, Mori K, Satoh N, Kasahara M, Yokoi H, Saito Y, Imamaki H, Nagae T, Ogawa Y, Barasch J, Sugawara A, Mukoyama M, Nakao K
Organizer
American Society of Nephrology(ASN)meeting
Place of Presentation
Philadelphia
Year and Date
20081100
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[Presentation] Urinary Ngal is a kidney injury biomarker which integrates information of damage in glomeruli, proximal tubules and distal nephrons2008
Author(s)
Mori K, Kuwabara T, Mukoyama M, Kasahara M, Yokoi H, Ogawa Y, Saito Y, Imamaki H, Sugawara A, Barasch J, Nakao
Organizer
International Society of Hypertension (ISH) meeting
Place of Presentation
Berlin
Year and Date
20080600
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[Presentation] Adrenomedullin gene transfer into rat kidney ameliorates obstructive renal fibrosis through inhibition of connective tissue growth factor and extracellular signal-regulated kinase2008
Author(s)
Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
Organizer
International Society of Hypertension(ISH)meeting
Place of Presentation
Berlin
Year and Date
20080600
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[Presentation] Distinct Urinary Excretion of Albumin, Beta-2 microglobulin and Neutrophil Gelatinase-Associated Lipocalin in Mouse Models of Diabetic Nephropathy2007
Author(s)
Kuwabara T, Mori K, Mukoyama M, Saito Y, Kasahara M, Yokoi H, Yoshioka T, Ogawa Y, Imamaki H, Sugawara A, Barasch J, Nakao K
Organizer
American Society of Nephrology(ASN)meeting
Place of Presentation
San Francisco
Year and Date
20071100
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[Presentation] Blood and Urinary Neutrophil Gelatinase-Associated Lipocalin (Ngal) Levels in the Treatment Courses of Proteinuric Glomerular Diseases2007
Author(s)
Mori K, Kuwabara T, Mukoyama T, Kasahara M, Yokoi H, Yoshioka T, Ogawa Y, Saito Y, Imamaki H, Sugawara A, Barasch J, Nakao K
Organizer
American Society of Nephrology(ASN)meeting
Place of Presentation
San Francisco
Year and Date
20071100
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