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2008 Fiscal Year Final Research Report

Screening of novel biomarkers and therapeutic targets in diabetic nephropathy

Research Project

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Project/Area Number 19590949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto University

Principal Investigator

SUGAHARA Akira  Kyoto University, 医学研究科, 臨床教授 (00312223)

Co-Investigator(Renkei-kenkyūsha) MORI Kiyoshi  京都大学, 医学研究科, 講師 (60343232)
SATOU Noriko  京都医療センター・臨床研究センター, 研究員 (80373512)
Project Period (FY) 2007 – 2008
Keywords腎臓学
Research Abstract

1型および2型糖尿病のマウスモデルを用いて、糖尿病性腎症の早期に発現増加が改善する遺伝子としてgremlin 1、growth arrest-specific 6、Wt-1、Rab3bなどを同定し、これらの因子の糖尿病性腎症への関与が示唆された。さらに糖尿病性腎症においては尿中Ngal が増加し、アンギオテンシン受容体阻害薬の投与により減少することを明らかにし、尿中Ngal の新規バイオマーカーとしての有用性を報告した。

  • Research Products

    (30 results)

All 2009 2008 2007 2006

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (20 results)

  • [Journal Article] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blocker in hypertensive patients2009

    • Author(s)
      Kasahara M, Mori K, Satoh N, Kuwabara T, Yokoi H, Shimatsu A, Sugawara A, Mukoyama M, Nakao K
    • Journal Title

      Nephrol Dial Transpl (in press)

    • Peer Reviewed
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons2009

    • Author(s)
      Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Yoshioka T, Ogawa Y, Imamaki H, Kusakabe T, Ebihara K, Omata M, Satoh N, Sugawara A, Barasch J, Nakao K
    • Journal Title

      Kidney Int 75(3)

      Pages: 285-94

    • Peer Reviewed
  • [Journal Article] Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury2008

    • Author(s)
      Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, Buchen C, Khan F, Mori K, Giglio J, Devarajan P, Barasch J
    • Journal Title

      Ann Intern Med 148(11)

      Pages: 810-9

    • Peer Reviewed
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis2008

    • Author(s)
      Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
    • Journal Title

      Kidney Int 74(1)

      Pages: 70-80

    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice2008

    • Author(s)
      Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, Yoshioka T, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K
    • Journal Title

      Kidney Int 73(4)

      Pages: 446-55

    • Peer Reviewed
  • [Journal Article] Myasthenia-like syndrome induced by cibenzoline overdose in a patient with chronic kidney disease2008

    • Author(s)
      Kawasaki H, Yahata K, Okamoto C, Imamaki H, Seta K, Sugawara A
    • Journal Title

      Nippon Jinzo Gakkai Shi 50(7)

      Pages: 942-7

    • Peer Reviewed
  • [Journal Article] Systemic AA amyloidosis caused by familial Mediterranean fever and response to colchicines2008

    • Author(s)
      Fukui N, Mukoyama M, Saito Y, Mori K, Kasahara M, Yokoi H, Ogawa Y, Kuwabara T, Sugawara A, Nakao K.
    • Journal Title

      Nippon Naika Gakkai Zasshi 97(12)

      Pages: 3046-8

    • Peer Reviewed
  • [Journal Article] Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage2007

    • Author(s)
      Mori K, Nakao K
    • Journal Title

      Kidney Int 71(10)

      Pages: 967-70

    • Peer Reviewed
  • [Journal Article] Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney2007

    • Author(s)
      Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K
    • Journal Title

      Am J Physiol Renal Physiol 293(4)

      Pages: 1363-72

    • Peer Reviewed
  • [Journal Article] Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone2006

    • Author(s)
      Makino H, Miyamoto Y, Sawai K, Mori K,Mukoyama M, Nakao K, Yoshimasa Y, Suga S
    • Journal Title

      Diabetes 55(10)

      Pages: 2747-56

    • Peer Reviewed
  • [Presentation] Urinary Neutrophil Gelatinase-Associated Lipocalin(Ngal)is a Powerful Biomarker of Disease Activity and Treatment Efficacy in Chronic Kidney Disease(CKD)2009

    • Author(s)
      Kuwabara T, Mori K, Mukoyama M, Sugawara A, Nakao K
    • Organizer
      日本循環器学会学術集
    • Place of Presentation
      大阪
    • Year and Date
      20090300
  • [Presentation] Reduction of urinary excretion of neutrophil gelatinaseassociated lipocalin(Ngal)by angiotensin receptor blockers(ARBs)in diabetic or obese subjects2008

    • Author(s)
      Kuwabara T, Mori K, Satoh N, Kasahara M, Yokoi H, Saito Y, Imamaki H, Nagae T, Ogawa Y, Barasch J, Sugawara A, Mukoyama M, Nakao K
    • Organizer
      American Society of Nephrology(ASN)meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      20081100
  • [Presentation] 2種の糖尿病性腎症モデルマウスの糸球体において共通に発現増加する遺伝子の網羅的解析2008

    • Author(s)
      森潔、〓原孝成、向山政志、笠原正登、横井秀基、斎藤陽子、小川喜久、今牧博貴、菅原照、中尾一和
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      東京
    • Year and Date
      20081000
  • [Presentation] 高血圧・高脂血症を伴うCKD(慢性腎臓病)患者における血圧コントロール後のスタチンによる蛋白尿減少、腎保護効果について2008

    • Author(s)
      岡本千夏、小泉三輝、菊地祐子、瀬田公一、八幡兼成、菅原照
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20081000
  • [Presentation] 内分泌因子・液性因子と腎予後予測-NgalとBNPを中心に-2008

    • Author(s)
      向山政志、森潔、笠原正登、原田昌樹、中尾一和
    • Organizer
      日本腎臓学会西部学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080900
  • [Presentation] Urinary Ngal is a kidney injury biomarker which integrates information of damage in glomeruli, proximal tubules and distal nephrons2008

    • Author(s)
      Mori K, Kuwabara T, Mukoyama M, Kasahara M, Yokoi H, Ogawa Y, Saito Y, Imamaki H, Sugawara A, Barasch J, Nakao
    • Organizer
      International Society of Hypertension (ISH) meeting
    • Place of Presentation
      Berlin
    • Year and Date
      20080600
  • [Presentation] Adrenomedullin gene transfer into rat kidney ameliorates obstructive renal fibrosis through inhibition of connective tissue growth factor and extracellular signal-regulated kinase2008

    • Author(s)
      Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
    • Organizer
      International Society of Hypertension(ISH)meeting
    • Place of Presentation
      Berlin
    • Year and Date
      20080600
  • [Presentation] 1型及び2型糖尿病に伴う糖尿病性腎症モデルマウスの糸球体における遺伝子発現変動パターンの網羅的解析2008

    • Author(s)
      森潔、〓原孝成、向山政志、斎藤陽子、笠原正登、横井秀基、吉岡徹朗、小川喜久、今牧博貴、菅原照、中尾一和
    • Organizer
      日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      20080500
  • [Presentation] 尿中Ngal 濃度の解析から考えられる理想の腎障害マーカー像(Kidney Biomarkerology 2008)2008

    • Author(s)
      森潔、向山政志、笠原正登、横井秀基、〓原孝成、中尾一和
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      20080500
  • [Presentation] 糖尿病性腎症モデルマウスの回復早期に発現変動する遺伝子群の同定2008

    • Author(s)
      森潔、〓原孝成、向山政志、斎藤陽子、笠原正登、横井秀基、小川喜久、今牧博貴、菅原照、中尾一和
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      青森
    • Year and Date
      20080500
  • [Presentation] ネフローゼ治療中の血中・尿中Neutrophil gelatinase-associated lipocalin (Ngal)濃度の推移2008

    • Author(s)
      〓原孝成, 森潔, 向山政志, 笠原正登,横井秀基, 小川喜久, 齋藤陽子, 今牧博貴, 菅原照, 中尾一和
    • Organizer
      日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      20080400
  • [Presentation] Urinary Ngal as an early biomarker for diabetic nephropathy in mice2008

    • Author(s)
      Mori K, Kuwabara T, Mukoyama M, Saito Y, Kasahara M, Yokoi H, Ogawa Y, Imamaki H, Nakao K
    • Organizer
      The Shiga International Symposium on Diabetic Nephropathy meeting
    • Place of Presentation
      Otsu
    • Year and Date
      20080300
  • [Presentation] Distinct Urinary Excretion of Albumin, Beta-2 microglobulin and Neutrophil Gelatinase-Associated Lipocalin in Mouse Models of Diabetic Nephropathy2007

    • Author(s)
      Kuwabara T, Mori K, Mukoyama M, Saito Y, Kasahara M, Yokoi H, Yoshioka T, Ogawa Y, Imamaki H, Sugawara A, Barasch J, Nakao K
    • Organizer
      American Society of Nephrology(ASN)meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      20071100
  • [Presentation] Blood and Urinary Neutrophil Gelatinase-Associated Lipocalin (Ngal) Levels in the Treatment Courses of Proteinuric Glomerular Diseases2007

    • Author(s)
      Mori K, Kuwabara T, Mukoyama T, Kasahara M, Yokoi H, Yoshioka T, Ogawa Y, Saito Y, Imamaki H, Sugawara A, Barasch J, Nakao K
    • Organizer
      American Society of Nephrology(ASN)meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      20071100
  • [Presentation] Neutrophil gelatinaseassociated lipocalinの臨床的意義及び腎不全の「山火事」理論2007

    • Author(s)
      森潔、向山政志、笠原正登、横井秀基、〓原孝成、吉岡徹朗、小川喜久、齊藤陽子、菅原照、中尾一和
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20070600
  • [Presentation] 腎不全におけるNgal : siderophore : Fe複合体の意義2007

    • Author(s)
      森潔、向山政志、笠原正登、中尾一和
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20070600
  • [Presentation] 夜間血圧コントロールによる蛋白尿減少と腎保護効果2007

    • Author(s)
      岡本千夏、小泉三輝、菊地祐子、瀬田公一、八幡兼成、菅原照.
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Year and Date
      20070500
  • [Presentation] 腎不全の「山火事」理論とNeutrophil gelatinase-associated lipocalin2007

    • Author(s)
      森潔、向山政志、笠原正登、横井秀基、〓原孝成、吉岡徹朗、小川喜久、齊藤陽子、菅原照、中尾一和
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Year and Date
      20070500
  • [Presentation] I型及びII型糖尿病に伴う糖尿病性腎症モデルマウスの糸球体における遺伝子発現変動パターンの網羅的解析2007

    • Author(s)
      〓原孝成、森潔、向山政志、齊藤陽子、笠原正登、横井秀基、吉岡徹朗、小川喜久、菅原照、中尾一和
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Year and Date
      20070500
  • [Presentation] Forest Fire Theory for Renal Failure and Clinical Impact of Neutrophil Gelatinase-Associated Lipocalin2007

    • Author(s)
      Mori K, Mukoyama M, Nickolas TL, Barasch J, Nakao K
    • Organizer
      International Society of Nephrology(ISN)meeting
    • Place of Presentation
      Brazil
    • Year and Date
      20070400

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Published: 2010-06-10   Modified: 2016-04-21  

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