2010 Fiscal Year Final Research Report
Role of BMP4 on the development of glomerular capillary tufts and the growth of proximal tubules
| Project/Area Number |
19590964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MIYAZAKII Yoichi Jikei University School of Medicine, 医学部, 講師 (60266690)
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| Project Period (FY) |
2007 – 2010
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| Keywords | mutants / glomerulus / noggin / VEGF |
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| Research Abstract |
In the basis of our prior studies, we hypothesized that BMP and VEGF from the glomerular podocytes have antagonistic roles for the development of glomerular capillary tufts. To assess the hypothesis, we generated inducible podocyte-specific BMP4 and VEGF transgenic mice (Tg), and analyzed phenotypes in double Tg. When compared to the single Tg, double Tg displayed more prominent phenotypes seen in the glomerulus and tubule. In conjunction with ex vivo study using mouse embryonic aortic ring, therefore, the result suggests that BMPand VEGF have collaborative effects on the tuft development, and BMP can stabilize newly formed capillary tufts by VEGF.
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