Molecular analyses in progressive renal diseases

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590967
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: YOKOYAMA Hitoshi Kanazawa Medical University, 医学部, 教授 (50191531)
• Project Period (FY): 2007 – 2009
• Keywords: 腎臓病 / 腎移植 / 疾患コホート / サイトカイン / ケモカイン / 組織適合抗原 / 機能分子

Research Abstract

We constructed prospectively the renal disease cohort including nephrotic syndrome (18 cases), lupus nephritis (33 cases), pauci-immune type rapidly progressive glomerulonephritis (RPGN, 25 cases) and renal transplanted subjects (154 cases) since 2007. We found the correlation between the genetic background (HLA-DRB1*090102) and the onset of pauci-immune type RPGN. We also revealed that the affects of lipids and total and high-molecular weight adiponectins, the non-classical HLA-G and the role of fibrocytes and pericytes in chronic allograft injury.

Research Products

• [Journal Article] Revised equations for estimated GFR from serum creatinine in Japan. (2009)
  • Author(s): S. Matsuo, E. Imai, M. Horio, Y. Yasuda, K. Tomita, K. Nitta, K. Yamagata, Y. Tomino, H. Yokoyama, A. Hishida
  • Journal Title: Am. J. Kidney Dis. Pages: 53982-992
  • Peer Reviewed
• [Journal Article] Biocompatibility and permeability of dialyzer membranes do not affect anemia, erythropoietin dosage or mortality in Japanese patients on chronic non-reuse hemodialysis:a prospective cohort study from the J-DOPPS II study. (2008)
  • Author(s): H. Yokoyama, et al
  • Journal Title: Nephron Clin. Pract. 109 Pages: c100-c108
  • Peer Reviewed
• [Journal Article] Ischemia-reperfusion injury as the leading cause of primary non-function in renal transplantation using donors with prolonged warm ischemic time. (2008)
  • Author(s): M. Asaka, H. Yokoyama, et al
  • Journal Title: Clin Transplant 22(Suppl19) Pages: 19-24
  • Peer Reviewed
• [Journal Article] Proteomic Analysis of Serum, Outflow Dialysate and Adsorbed Protein onto Dialysis Membranes (Polysulfone and PMMA) during Hemodialysis Treatment Using SELDI-TOF-MS. (2006)
  • Author(s): Ishikawa I, Chikazawa Y, Saton K, Nakagawa M, Imamura H, Hayama S, Yamaya H, Asaka M, Tomosugi N, Yokoyama H, Matsumoto K
  • Journal Title: Am J Nephrol 26 Pages: 372-380
  • Peer Reviewed
• [Presentation] Statins preserved the function of transplanted kidneys under controlled blood pressure. (2008)
  • Author(s): H. Yokoyama
  • Organizer: Renal Week 2008 ASN's 41st Annual Meeting&Scientific Exposition.
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-08
• [Presentation] Chronic allograft injury (CAI) as the aspect of chronic kidney disease (CKD). (2008)
  • Author(s): H. Yokoyama
  • Organizer: The 38th Annual Congress of the Korean Society for Transplantation&The 7th Korea-Japan Transplantation Forum.
  • Place of Presentation: Soul
  • Year and Date: 2008-10-11
• [Book] Annual review 2010:ヒト膜性腎症の原因抗原:neutral endopeptidaseとM-type phospholopase A2 receptor (2010)
  • Author(s): 横山仁, 他
  • Total Pages: 84-89
  • Publisher: 中外医学社
• [Book] 専門医のための腎臓病学 第2版:膜性腎症 (2009)
  • Author(s): 横山仁, 他
  • Total Pages: 333-343
  • Publisher: 医学書院