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2008 Fiscal Year Final Research Report

Chronic kidney disease (CKD) as a risk factor for cardiovascular diseases: investigation on pathogenesis and development of therapeutic strategy

Research Project

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Project/Area Number 19590969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

KASHIHARA Naoki  Kawasaki Medical School, 医学部, 教授 (10233701)

Co-Investigator(Kenkyū-buntansha) KOMAI Norio  川崎医科大学, 医学部, 講師 (40368626)
SATOH Minoru  川崎医科大学, 医学部, 講師 (70449891)
Project Period (FY) 2007 – 2008
Keywords慢性腎臓病(CKD) / 生活習慣病 / 心血管病 / メタボリックシンドローム / 肥満 / レニン・アンジオテシン系 / 高血圧 / 血管内皮障害
Research Abstract

本邦で慢性腎臓病(Chronic Kidney Disease : CKD)が増加している。その主因は糖尿病、肥満、メタボリックシンドローム等の生活習慣病の増加と高齢化である。CKDは腎不全をもたらすだけでなく、心血管病(CVD)の強い危険因子でもある。本研究では、まずCKDの発症・進展機構の詳細を解明した。特になぜアルブミン尿が出現しCVDを合併するのか、その機構を明らかにした。本研究で得られたCKDの基盤病態の理解は、本症の予防と治療法立案に貢献するものである。

  • Research Products

    (13 results)

All 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (5 results)

  • [Journal Article] Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy2009

    • Author(s)
      Namikoshi T, Tomita N, Satoh M, Sakuta T, Kuwabara A, Kobayashi S, Higuchi Y, Nishijima F, Kashihara N
    • Journal Title

      Hypertens Res 32

      Pages: 194-200

    • Peer Reviewed
  • [Journal Article] Direct measurement of nitric oxide concentration in CAPDdialysate2009

    • Author(s)
      Mochizuki S, Takayama A, Sasaki T, Horike H, Kashihara N, Ogasawara Y, Kajiya F, Kitawaki T, Oka H
    • Journal Title

      Perit Dial Int. 29

      Pages: 111-114

    • Peer Reviewed
  • [Journal Article] C/EBP- beta modulates transcription of tubuleinterstitial nephritis antigen in obstructive uropathy2009

    • Author(s)
      Xie P, Sun L, Nayak B, Haruna Y, Liu FY, Kashihara N, Kanwar YS
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 807-819

    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy2008

    • Author(s)
      Satoh M, Fujimoto S, Arakawa S, Yada T, Namikoshi T, Haruna Y, Horike H, Sasaki T, Kashihara N
    • Journal Title

      Nephrol Dial Transplant 23

      Pages: 3806-13

    • Peer Reviewed
  • [Journal Article] Olmesartan ameliorates progressive glomerular injury in subtotal nephrectomized rats through suppression of superoxide production2008

    • Author(s)
      Fujimoto S,Satoh M,Horike H,Hatta H,Haruna Y,Kobayashi S,Namikoshi T,Arakawa S,Tomita N,Kashihara N
    • Journal Title

      Hypertens Res 31

      Pages: 305-313

    • Peer Reviewed
  • [Journal Article] Rap1b GTPase ameliorates glucose-induced mitochondrialdysfunction2008

    • Author(s)
      Sun L, Xie P, Wada J, Kashihara N, Liu FY, Zhao Y, Kumar D, Chugh SS, DaneshFR, Kanwar YS
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 2293-2301

  • [Journal Article] Pioglitazone enhances the antihypertensive and renoprotective effects of candesartan in Zucker obese rats fed a high-protein diet2008

    • Author(s)
      Namikoshi T, TomitaN, Satoh M,Haruna Y, Kobayashi S, Komai N,Sasaki T, Kashihara N
    • Journal Title

      Hypertens Res 31

      Pages: 745-755

    • Peer Reviewed
  • [Journal Article] Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy2008

    • Author(s)
      kobayashi S, Satoh M, Namikoshi T, Haruna Y, Fujimoto S, Arakawa S, Komai N, Tomita N, Sasaki T, Kashihara N
    • Journal Title

      Clin Exp Nephrol.Clin Exp Nephrol 12

      Pages: 119-125

    • Peer Reviewed
  • [Presentation] Uremic Toxins and High Dietary Protein Intake Induce Endo thelial Dysfunction in Rats with Chronic Kidney Didease2009

    • Author(s)
      Namikoshi T, Tomita N, Satoh M, Kuwabara A, Nagasu H, Yorimitsu D, Komai N,Kashihara N
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
  • [Presentation] Azelnidipin Prevent Renal Dysfunction in Dahl Salt-Sensitive Rats by Suppression of Sympathetic Nerve sysytem2009

    • Author(s)
      Nagasu H, Satoh M, Kuwabara A, Yorimitsu D, Namikoshi T, Tomita N,Sasaki T, Kashihara N
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
  • [Presentation] Angiotensin II Type 1 Receptor Blocker Ameliorates Uncoupled Endothelial Nitric Oxide Synthase in Rats with Streptozotocine Induced Diabetic Nephropathy2008

    • Author(s)
      Satoh M, Fujimoto S, Haruna Y, Yada T,Kuwabara A, Nagasu H,Yorimitsu D, Namikoshi T, Tomita N, Sasaki T, Kashihara N
    • Organizer
      American Society of Nephrology 41st Annual Meeting & Scientific Exposition
    • Place of Presentation
      Philadelphia, Pennsylvania
    • Year and Date
      2008-11-06
  • [Presentation] Oral adsorbent AST-120 ameliorates endothelial dysfunction and alleviates oxidative stress in aorta independent of renal function in subtotally nephrectomized rats2008

    • Author(s)
      Namikoshi T, Tomita N, Satoh M, Sakuta T, Kuwabara A, Nagasu H, Yorimitsu D, Higuchi Y,Nishijima F, Kashihara N
    • Organizer
      American Society of Nephrology 41st Annual Meeting & Scientific Exposition
    • Place of Presentation
      Philadelphia, Pennsylvania
    • Year and Date
      2008-11-06
  • [Presentation] Chronic Kidney disease as a carduovascular risk factor-Analysis by visualization of the in vivo renal microcirculation2008

    • Author(s)
      Satoh M, Kashihara N
    • Organizer
      第34回日本微小循環学会年次総会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-21

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Published: 2010-06-10   Modified: 2016-04-21  

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