Elucidation of pathophysiological roles of integrins and therapeutic application by regulating integrins in chronic kidney disease

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590972
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: TAMURA Masahito University of Occupational and Environmental Health, Japan, 大学病院, 准教授 (40330980)
• Co-Investigator(Kenkyū-buntansha): SERINO Ryota 産業医科大学, 医学部, 助教 (00309957)
• Project Period (FY): 2007 – 2009
• Keywords: インテグリン / 慢性腎臓病 / Focal adhesion kinase / 細胞接着分子 / 慢性腎炎

Research Abstract

We investigated the modulatory effects of extracellular matrix (ECM) accumulation on the expression of cell adhesion molecules involved in the progression of renal diseases. Our results suggest that accumulation of pathological ECM components such as type I and III collagens might play a role in the progression of glomerular diseases by enhancing ICAM-1 expression and leukocyte adhesion to mesangial cells.

Research Products

• [Journal Article] Renoprotective effects of telmisartan in patients with advanced chronic kidney disease. (2010)
  • Author(s): TokunagaM, KabashimaN, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Fujimoto Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y, Tamura M
  • Journal Title: Clin Nephrol 73(2) Pages: 139-146
  • Peer Reviewed
• [Journal Article] An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. (2010)
  • Author(s): Miyamoto T, Tamura M, Kabashima N, Serino R, Shibata T, Furuno Y, Miyazaki M, Baba R, Sato N, Doi Y, Okazaki M, Otsuji Y
  • Journal Title: Nephrol Dial Transplant 25(4) Pages: 1109-1119
  • Peer Reviewed
• [Journal Article] Minimal change nephrotic syndrome in a patient with strongyloidiasis. (2010)
  • Author(s): Miyazaki M, Tamura M, Kabashima N, Serino R, Shibata T, Miyamoto T, Furuno Y, Nishio T, Ohara J, Sakurai T, Otsuji Y:
  • Journal Title: Clin Exp Nephrol (in press)
  • Peer Reviewed
• [Journal Article] A case report of steroid-resistant ANCA-related vasculitis successfully treated by mizoribine in a hemodialysis patient. (2009)
  • Author(s): Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Fujimatsu S, Muta T, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Ther Aphre Dial 13(1) Pages: 77-79
  • Peer Reviewed
• [Journal Article] Electromagnetic Interference with a bipolar pacemaker by an induction heating (IH) rice cooker. (2009)
  • Author(s): Nagatomo T, Abe H, Kohno R, Toyoshima T, Fujimoto H, Kondo S, Kabashima N, Takeuchi M, Tamura M, Okazaki M, Otsuji Y
  • Journal Title: Int Heart J 50(1) Pages: 133-137
  • Peer Reviewed
• [Journal Article] Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. (2009)
  • Author(s): Shibata T, Tamura M, Kabashima N, Serino R, Tokunaga M, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Life Sci 84 Pages: 725-731
  • Peer Reviewed
• [Journal Article] Hepatic angiosarcoma-a rare liver tumor in a hemodialysis patient. (2009)
  • Author(s): Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Ohtsuki M, Otsuji Y
  • Journal Title: Clin Nephrol 71(5) Pages: 590-592
  • Peer Reviewed
• [Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. (2008)
  • Author(s): Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, January CT, Otsuji Y
  • Journal Title: Br J Pharmacol 153(3) Pages: 439-447
  • Peer Reviewed
• [Journal Article] Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient (2008)
  • Author(s): Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Clin Nephrol 69(5) Pages: 393-394
  • Peer Reviewed
• [Journal Article] Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient. (2008)
  • Author(s): Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Clin Nephrol 70(5) Pages: 445-446
  • Peer Reviewed
• [Journal Article] PTEN reduces cuff-induced neointima formation and proinflammatory cytokines. (2007)
  • Author(s): Koide S, Okazaki M, Tamura M, Ozumi K, Takatsu H, Kamezaki F, Tanimoto A, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y
  • Journal Title: Am J Physiol Heart Circ Physiol 292(6) Pages: H2824-2831
  • Peer Reviewed
• [Presentation] Effects of Icodextrin onthe Integrin-Mediated Wound Healing of Peritoneal Mesothelial Cells (2009)
  • Author(s): Tamura M, et al.
  • Organizer: Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-10-31
• [Book] Icodextrin透析液の生体適合性、Annual Review腎臓2009 (2009)
  • Author(s): 田村雅仁、宮本哲
  • Total Pages: 158-165
  • Publisher: 中外医学社