2008 Fiscal Year Final Research Report
Gene therapy with Sendai virus vector ta rgeting for microcirculatory construct in brain infarction
| Project/Area Number |
19590993
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
OOBOSHI Hiroaki Kyushu University, 大学病院, 講師 (10311838)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 遺伝子治療 / ベクター / 脳梗塞 / 遺伝子導入 / 脳虚血 / 血管透過性 |
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| Research Abstract |
齧歯類の実験的脳虚血モデルを用い、脳虚血作製後の治療開始であっても、可溶性Flt-1 の遺伝子導入が血管透過性亢進の著明な阻害作用を示し、脳浮腫ならびに脳梗塞を軽減することを明らかにした。また、国産の遺伝子導入ベクターであるセンダイウイルスベクターを用いた脳への遺伝子導入がアデノウイルスベクターと同様の有効性を示すことを認めた。脳虚血部位における微小血管構築の破綻と血管透過性亢進に対する保護作用が期待され、国産技術による臨床的な遺伝子治療の開発につながる成果が得られたと考えられる。
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[Journal Article] Fukuoka Stroke Registry ; Hisayama study : Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population : the Fukuoka Stroke Registry and the Hisayama study2008
Author(s)
Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M
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Journal Title
Eur J Neurol 15
Pages: 481-486
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[Journal Article] Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population2008
Author(s)
Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, ugimori H, Yamashita Y, Wakugawa Y, Kubo , Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M
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Journal Title
The Fukuoka Stroke Registry and the Hisayama Study 25
Pages: 417-422
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[Journal Article] Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger2007
Author(s)
Ifuku M, Farber K, Okuno Y, Yamakawa Y, Miyamoto T, Nolte C, Merrino VF, Kita S, Iwamoto T, Komuro I, Wang B, Cheung G, Ishikawa E, Ooboshi H, Bader M, Wada K, Kettenmann H, Noda M
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Journal Title
J Neurosci 27
Pages: 13065-13073
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[Journal Article] NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan : the Fukuoka Stroke Registry and the Hisayama study2007
Author(s)
Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M
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Journal Title
Eur J Neurol 14
Pages: 1091-1097
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[Presentation] Neuroprotection and neurogenesis by post-ischemic gene transfer of midkine2008
Author(s)
Ooboshi H, Ishikawa E, Kumai Y, Takada J, Nakamura K, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M
Organizer
6^<th> World Stroke Conference
Place of Presentation
Vienna, Austria
Year and Date
2008-09-26
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[Book] Recent Advances in Neurogenesis
Author(s)
Ooboshi H, Ishikawa E, Kumai Y, Shichita T, Takada J, Ibayashi S
Publisher
Research Signpost : Potentials of gene therapy for neuroprotection and neurogenesis in brain ischemia(in press)
