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2009 Fiscal Year Final Research Report

Regeneration research of peripheral nerve injury via macrophage stimulated by oxidized galectin-1

Research Project

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Project/Area Number 19591004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNihon institute of Medical Science

Principal Investigator

YOSHIMURA Kazunori  Nihon institute of Medical Science, 保健医療学部, 教授 (20158497)

Co-Investigator(Renkei-kenkyūsha) KAMETANI Fuyuki  (財)東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員 (70186013)
Research Collaborator KADOYA Toshihiko  前橋工科大学, 工学部・生物工学科, 教授 (40551875)
SAKAMOTO Yasushi  埼玉医科大学, 医学部・中央研究施設, 施設長・教授 (80178582)
KITAMURA Kunio  埼玉医科大学, 保健医療学部・健康医療科学科, 教授 (70049857)
MIYAZAKI Takashi  埼玉医科大学, 医学部・地域医学医療センター, 助教 (30265417)
Project Period (FY) 2007 – 2009
Keywords神経病態生化学 / 神経再生促進
Research Abstract

We identified several kind of proteins related with signal transduction of oxidized galectin-1 in macrophages stimulated with oxidized galectin-1 by fluorescence two dimensional difference gel electrophoreis (2D DIGE). The proteins were arginase, GRP78, transaldolase, glia maturation factor, and malate dehydrogenase. We have been investigating about macrophages stimulated by oxidized galecin-1 in detail with Real Time RT-PCR, Western blot, Calcium Imaging, and proteome analysis.

  • Research Products

    (14 results)

All 2010 2009 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results)

  • [Journal Article] Biological significance of protein modification in aging and calorie restriction.2010

    • Author(s)
      Nakamura A, Kawamura K, Kametani F, Nakamoto H, Goto S.
    • Journal Title

      Ann New York Acad Sci (in press)

    • Peer Reviewed
  • [Journal Article] Aberrant expressions of aquaporin-1 in association with capillarized sinusoidal endotherial cells in cirrhotic rat live.2010

    • Author(s)
      Yokomori H., Oda M., Yoshimura K., Watanabe S., Hibi T.
    • Journal Title

      Med Mol Morphol. 43(1)

      Pages: 6-12

    • Peer Reviewed
  • [Journal Article] Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II.2010

    • Author(s)
      Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Yasuhara S, Zhang B, Yan J, Mori M, Naiki H, Higuchi, K.
    • Journal Title

      Biochim Biophys Acta 1794

      Pages: 1517-1529

    • Peer Reviewed
  • [Journal Article] A possible connection between psychosomatic symptoms and daily rhythmicity in growth hormone secretion in healthy Japanese students.2009

    • Author(s)
      Nagane, M., Yoshimura, K., Watanabe, SI., Nomura, M.
    • Journal Title

      J Circadian Rhytms 7

      Pages: 10

    • Peer Reviewed
  • [Journal Article] Caveolin-1 and Rac regulate endothelial capillary-like tubular formation and fenestral constraction in sinusoidal endothelial cells.2009

    • Author(s)
      Yokomori, H., Oda, M., Yoshimura, K., Nagai, T., Fujimaki, K., Watanabe, S., Hibi, T.
    • Journal Title

      Liver Int 29(2)

      Pages: 266-276

    • Peer Reviewed
  • [Journal Article] A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1.2009

    • Author(s)
      Yamamoto, K., Yoshimura, K., Kitada, K., Nakahara, J., Seiwa, C., Ueki, T., Shimoda, Y., Ishige, A., Watanabe, K., Asou, H.
    • Journal Title

      J Neurosci Res 87(2)

      Pages: 503-513

    • Peer Reviewed
  • [Journal Article] Hereditary rimmed vacuole myopathy showing interstitial amyloid deposition in muscle tissue.2009

    • Author(s)
      Kojima Y, Sakai K, Ishida C, Asaka T, Hamaguchi T, Nozaki I, Fukushima K, Tsuchiya A, Kametani F, Yazaki M, Okino S, Yamada M.
    • Journal Title

      Muscle & Nerve 40

      Pages: 472-475

    • Peer Reviewed
  • [Journal Article] Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.2009

    • Author(s)
      Nonaka T, Kametani F, Arai T, Akiyama H, Hasegawa M.
    • Journal Title

      Hum Mol Genet 18

      Pages: 3353-3364

    • Peer Reviewed
  • [Journal Article] Identification of casein kinase-1 phosphorylation sites on TDP-43.2009

    • Author(s)
      Kametani F, Nonaka T, Suzuki T, Arai T, Dohmae N, Akiyama H, Hasegawa M.
    • Journal Title

      Biochem Biophys Res Commun 382

      Pages: 405-409

    • Peer Reviewed
  • [Journal Article] Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.2009

    • Author(s)
      Yamashita M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina N, Bachurin SO, Akiyama H, Goedert M, Hasegawa M.
    • Journal Title

      FEBS Lett 583

      Pages: 2419-2424

    • Peer Reviewed
  • [Presentation] Proteomic analysis of macrophages stimulated with oxidized galectin-1.2007

    • Author(s)
      Kazunori Yoshimura, Fuyuki Kametani, Kayo Fujimaki, Takashi Miyazaki, Hidenori Horie, Shu-Ichi Watanabe, Toshihiko Kadoya
    • Organizer
      47th Annual Meeting of The American Society for Cell Biology. Annual Meeting Program. No. 2015
    • Place of Presentation
      Washington
    • Year and Date
      20071201-20070105
  • [Presentation] Proteomic analysis of human astrocytes treated with propofol.2007

    • Author(s)
      Toshiko Maruo, Kazunori Yoshimura, Kayo Fujimaki, Masahio Nomura, Shu-Ichi Watanabe, Masahiko Suzuki, Hideki Miyao
    • Organizer
      2007 Annual Meeting for Experimental Biology. Abstracts, Abstract No. 791.
    • Place of Presentation
      Washington Convention Center, 801 Mount Vernon Place, NW, Washington, DC
    • Year and Date
      2007-04-30
  • [Presentation] Sho Matsushita. Cerebral metabolism of glucose in chronic intermittent hyoxia: a nuclear magnetic resonance spectroscopy study.

    • Author(s)
      Masami Nishina, Masahiko Suzuki, Naomi Takehara, M Matsushita, Kazunori Yoshimura
    • Organizer
      Program/Abstract#482. 5/RR38. Society for Neuroscience 2008 Meeting.
    • Place of Presentation
      Washington Convention Center, C. Washington Convention Center, 801 Mount Vernon Place, NW, Washington, DC
  • [Presentation] Analysis of the topology of the microsomal epoxide hydrolase on the cell surface with monoclonal antibodies with different epitope specificiteis.

    • Author(s)
      Hongying Duan, Kazunori Yoshimura, Nobuharu Kobayashi, Akira Takagi, Masanori Matsui, Satoshi Ohno, Kazuo Sugiyama, Christophe Morisseau, Bruce D. Hammock, Toshitaka Akatsuka
    • Organizer
      Program/Abstract #479. 31. Experimental Biology 2008 Meeting.
    • Place of Presentation
      San Diego Convention Center, CA, U.S.A.

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Published: 2011-06-18   Modified: 2016-04-21  

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