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2008 Fiscal Year Final Research Report

Amelioration of pathological phenotypes of vascular smooth muscle cells by the sLR11 regulation

Research Project

  • PDF
Project/Area Number 19591036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionChiba University

Principal Investigator

BUJO Hideaki  Chiba University, 大学院・医学研究院, 教授 (80291300)

Project Period (FY) 2007 – 2008
Keywords動脈硬化 / 平滑筋細胞 / 内膜中膜肥厚 / 遊走 / アンギオテンシンII / バイオマーカー
Research Abstract

放出可溶化LR11を用いた内膜SMCsの病的形質変換の修飾を解明し内膜平滑筋細胞バイオマーカーとしての臨床的意義を探索した。内膜平滑筋遺伝子LR11機能を修飾することにより動脈硬化巣を変化させた。血中可溶型LR11濃度が従来の動脈硬化危険因子とは独立した動脈硬化マーカーであった。可溶型LR11の血中濃度は動脈硬化症における新規の血管傷害バイオマーカーとなると考えられる。

  • Research Products

    (3 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease2009

    • Author(s)
      Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Sjobata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Prtersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St. George-Hyslop P.
    • Journal Title

      Nat. Genet 39

      Pages: 168-177

    • Peer Reviewed
  • [Journal Article] AngII-stimulated migration of vascular SMC is dependent on LR112008

    • Author(s)
      Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, Shibasaki M, Azuma K, Harigaya K, Schneider WJ, Saito Y.
    • Journal Title

      J. Clin. Invest 118

      Pages: 2733-2746

    • Peer Reviewed
  • [Journal Article] A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells,accelerates formation of lipid-laden macrophages2007

    • Author(s)
      Ohwaki K, Bujo H, Jiang M, Yamazaki H, Schneider WJ, Saito Y.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol 27

      Pages: 1050-1056

    • Peer Reviewed

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Published: 2010-06-10   Modified: 2016-04-21  

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