• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Final Research Report

Regression of Atherosclerosis by the regulation of nitric oxide and superoxide on vascular endocrinology and vascular aging

Research Project

  • PDF
Project/Area Number 19591043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionNagoya University

Principal Investigator

HAYASHI Toshio  Nagoya University, 医学部附属病院, 講師 (80303634)

Co-Investigator(Kenkyū-buntansha) UMEGAKI Hiroyuki  名古屋大学, 医学部附属病院, 助教 (40345898)
Project Period (FY) 2007 – 2008
Keywords一酸化窒素 / 動脈硬化症 / 細胞老化 / エストロゲン / 糖尿病 / 動脈硬化退縮 / 血管内皮細胞 / NOドナー
Research Abstract

高齢者を念頭にした老化血管における動脈硬化症退縮における血管老化制御の可能性を検討した.まず動脈硬化症への老化の関与及び一酸化窒素(NO)の老化に対する効果や冠危険因子との相互作用を検討した.次いで、老化に加えて高齢者に寄与の大きい動脈硬化危険因子としてエストロゲン(欠乏)、糖尿病、そして治療手段であり老化への直接作用もあるインスリンの老化及び血管機能への影響を検討した.

  • Research Products

    (54 results)

All 2009 2008 2007

All Journal Article (23 results) Presentation (26 results) Book (4 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] and on behalf of Japan CDM group Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals : Changes in the risk for atherosclerotic diseases at various ages2009

    • Author(s)
      Hayashi T, Kawashima S, Itoh H, Yamada N, (他8名1番目)
    • Journal Title

      Diabetes Care (in press)

  • [Journal Article] Nitric oxide and endothelial cellular senescence2008

    • Author(s)
      Hayashi T, Yano K, (他4名1番目)
    • Journal Title

      Pharmacol Ther 120

      Pages: 333-9

  • [Journal Article] Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus2008

    • Author(s)
      Sasaki N, Yamashita T, Takaya T, Shinohara M, Fukatsu A, Hayashi T, (他6名6番目)
    • Journal Title

      Arterioscler Thromb Vasc Biol 28

      Pages: 1068-76

  • [Journal Article] Pitavastatin Shows Promise in Treatment of Patients With Type 2 Diabetes2008

    • Author(s)
      Hayashi T, Iguchi A
    • Journal Title

      Review of Endocrinology 1

      Pages: 1-3

  • [Journal Article] and on behalf of Japan CDM group Importance of Lipid Levels in Elderly Diabetic Individuals-Baseline Characteristics and 1-year Survey of Cardiovascular Events-2008

    • Author(s)
      Hayashi T, Kawashima S, (他10名1番目)
    • Journal Title

      Circulation Journal 72

      Pages: 218-225

  • [Journal Article] Visceral fat contribution of insulin resistance in elderly people2008

    • Author(s)
      Umegaki H, Haimoto H, Kario K
    • Journal Title

      J Am Geriatr Soc. 56

      Pages: 1375-5

  • [Journal Article] Volkow ND. D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats2008

    • Author(s)
      Thanos PK, Michaelides M, Umegaki H
    • Journal Title

      Synapse 62

      Pages: 481-6

  • [Journal Article] Discontinuation of donepezil for the treatment of Alzheimer's disease in geriatric practice2008

    • Author(s)
      Umegaki H, Itoh A, Suzuki Y, Nabeshima T
    • Journal Title

      Int Psychogeriatr 20

      Pages: 800-6

  • [Journal Article] Glucose control levels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysfunction in diabetic elderly2008

    • Author(s)
      Umegaki H, Kawamura T, Mogi N, Umemura T, Kanai A, Sano T
    • Journal Title

      Age Ageing 37

      Pages: 458-61

  • [Journal Article] Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats2008

    • Author(s)
      Zhu W, Zhang R, Hu C, Umegaki H
    • Journal Title

      Neuro Endocrinol Lett 29

      Pages: 159-62

  • [Journal Article] Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes : a 2-year follow-up study2008

    • Author(s)
      Haimoto H, Iwata M, Wakai K, Umegaki H
    • Journal Title

      Diabetes Res Clin Pract 79

      Pages: 350-6

  • [Journal Article] Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients2008

    • Author(s)
      Umegaki H, Iimuro S (他6名, 1番目)
    • Journal Title

      Neurobiol Aging 29

      Pages: 1022- 6

  • [Journal Article] Nitric oxide (NO) metabolites are associated with survival in older patients2007

    • Author(s)
      Hayashi T, Nomura H, Osawa M, Funami J, Miyazaki A, Iguchi A
    • Journal Title

      J Am Geriatr Soc 55

      Pages: 1398-403

  • [Journal Article] Alp NJ, Channon KM, Yokoyama M, Kawashima S. A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression2007

    • Author(s)
      Takaya T, Hirata KI, Yamashita T, Shinohara M, Sasaki N, Hayashi T, (他10名,6番目)
    • Journal Title

      Arterioscler Thromb Vasc Biol 27

      Pages: 1632-1637

  • [Journal Article] Efficacy and Safety Expert of Opinion on Pharmacology2007

    • Author(s)
      Hayashi T, Yokote K, Saito Y, Iguchi A
    • Journal Title

      Pitavastatin 8

      Pages: 2315-27

  • [Journal Article] Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly post menopausal women2007

    • Author(s)
      Ding Qungfang, *Hayashi T, (他5名, 2番目)
    • Journal Title

      JDiabetes and its Complication 21

      Pages: 315-9

  • [Journal Article] Possible Usefulness of Apocynin, an NADPH Oxidase Inhibitor, for Nitrate Tolerance : Prevention from Nitric Oxide Donor-Induced Endothelial Cell Abnormalities2007

    • Author(s)
      Fukatsu A, Hayashi T, (他6名, 2番目)
    • Journal Title

      Am J Physiol Heart Circ Physiol 293

      Pages: 790-7

  • [Journal Article] High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase : implications for atherosclerosis2007

    • Author(s)
      Hayashi T, Juliet PA, Miyazaki A, Ignarro LJ, Iguchi A
    • Journal Title

      Biochim Biophys Acta 1772

      Pages: 364-72

  • [Journal Article] beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes2007

    • Author(s)
      Hayashi T, (他6名, 1番目)
    • Journal Title

      Life Sci 80

      Pages: 592-9

  • [Journal Article] 17beta-estradiol antagonizes the down- regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose : relevance to postmenopausal diabetic cardiovascular disease2007

    • Author(s)
      Miyazaki-Akita A, Hayashi T, (他5名, 2番目)
    • Journal Title

      J Pharmacol Exp Ther 320

      Pages: 591-8

  • [Journal Article] Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin2007

    • Author(s)
      Osawa M, Hayashi T. (他5名2番目)
    • Journal Title

      Nitric Oxide 16

      Pages: 157-63

  • [Journal Article] Attitudes toward disclosing the diagnosis of dementia in Japan2007

    • Author(s)
      Umegaki H, Onishi J, Suzuki Y, Endo H, Iguchi A
    • Journal Title

      Int Psychogeriatr 19

      Pages: 253-65

  • [Journal Article] Which two questions of Mini-Mental State Examination (MMSE) should we start from2007

    • Author(s)
      Onishi J, Suzuki Y, Umegaki H, Kawamura T, Imaizumi M, Iguchi A
    • Journal Title

      Arch Gerontol Geriatr 44

      Pages: 43-8

  • [Presentation] Low HDL- cholesterol is associated with the risk of stroke in elderly diabetic individuals : Changes in the risk for atherosclerotic diseases at various ages2009

    • Author(s)
      Hayashi T. (他10名1番目)
    • Organizer
      American Diabetes Association
    • Place of Presentation
      New Orleans USA
    • Year and Date
      2009-06-06
  • [Presentation] The role of glucose and insulin on endothelial senescence- The relation of diversity effect of insulin and telomerase-2009

    • Author(s)
      Hayashi T. (他3名1番目)
    • Organizer
      Annual Scientific Meeting American Geriatrics Society
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-04-29
  • [Presentation] Vascular senescence and NO in asian elderly2008

    • Author(s)
      Hayashi T
    • Organizer
      Invited speech at Symposium of Konkuk University
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-17
  • [Presentation] siRNAを用いた老化関連疾患の病態解明2008

    • Author(s)
      林登志雄
    • Organizer
      薬物活性シンポジウムRNA干渉
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-23
  • [Presentation] "Health of Chinese elderly female" Approach for the Healthy Longevity in Asia2008

    • Author(s)
      Zhang J, Hayashi T
    • Organizer
      5th Asia/Oceania Geriatric and Gerontology International Meeting Symposium "Approach for the Healthy Longevity in Asia"
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-23
  • [Presentation] The Healthy Longevity in Japan2008

    • Author(s)
      Hayashi T
    • Organizer
      5th Asia/Oceania Geriatric and Gerontology International Meeting Symposium "Approach for the Healthy Longevity in Asia"
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-23
  • [Presentation] Metabolic syndrome and Diabetes in Chinese elderly female2008

    • Author(s)
      Ding Qung-Fan D, Hayashi T
    • Organizer
      5^<th>Asia/Oceania Geriatric and Gerontology International Meeting Symposium "The Health in Asian elderly female"
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-20
  • [Presentation] Pathophysiological Character of metabolic syndrome in Asian elderly female2008

    • Author(s)
      Funami J, Hayashi T
    • Organizer
      5^<th>Asia/Oceania Geriatric and Gerontology International Meeting Symposium "The Health in Asian elderly female"
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-20
  • [Presentation] Metabolic syndrome in Japan, Future attitude as Asian geriatricians2008

    • Author(s)
      Hayashi T
    • Organizer
      5^<th>Asia/Oceania Geriatric and Gerontology International Meeting Symposium "The Health in Asian elderly female"
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-20
  • [Presentation] HDL cholesterol is more important than glucose control in prevention of athero- sclerotic diseases in Asian diabetic elderly2008

    • Author(s)
      Hayashi T
    • Organizer
      Symposium 5th Congress of European Union Geriatric Medicine Society
    • Place of Presentation
      Copenhagen, Denmark (press release)
    • Year and Date
      2008-09-05
  • [Presentation] インスリンの細胞老化ストレスを介する動脈硬化への作用 Insulin exerts opposite control on high glucose-induced endothelial cellular senescence2008

    • Author(s)
      林登志雄
    • Organizer
      第40回に本動脈硬化学会シンポジウム「細胞ストレスと動脈硬化」
    • Place of Presentation
      筑波
    • Year and Date
      2008-07-15
  • [Presentation] 各種高脂血症薬の糖尿病性心血管合併症進展予防効果の総合的検討-二年間の解析より-2008

    • Author(s)
      林登志雄, 伊奈孝一郎, 井口昭久
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
  • [Presentation] 動脈硬化症における加齢と性の役割-本邦閉経後女性の心血管病リスクの面から-2008

    • Author(s)
      林登志雄
    • Organizer
      第8回日本抗加齢医学会バトルセッション : 女性ホルモン補充療法をめぐる議論(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2008-05-09
  • [Presentation] アジア地区高齢女性における動脈硬化性疾患と遺伝子変異に関する検討2008

    • Author(s)
      伊奈孝一郎, 林登志雄, 平井寿子, F. J., 井口昭久
    • Organizer
      第8回日本NO学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-08
  • [Presentation] LDL and HDL cholesterol might play more important role than glucose control in the prevention of ischemic cardiovascular disease in Japanese diabetic old and old2008

    • Author(s)
      Hayashi T (他3名1番目)
    • Organizer
      Annual Scientific Meeting American Geriatrics Society
    • Place of Presentation
      Washington USA
    • Year and Date
      2008-05-01
  • [Presentation] The effect of NO in endothelial senescence2008

    • Author(s)
      Hayashi T (他3名1番目)
    • Organizer
      Annual Scientific Meeting American Geriatrics Society
    • Place of Presentation
      Washington USA
    • Year and Date
      2008-05-01
  • [Presentation] Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance : prevention of NO donor-induced endothelial cell abnormalities2008

    • Author(s)
      Hayashi T (他3名1番目)
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-23
  • [Presentation] Nitric Oxide Metabolites Are Associated with Survival in Older Patients2008

    • Author(s)
      Hayashi T (他3名1番目)
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-23
  • [Presentation] グルコース負荷内皮細胞老化と内皮機能-糖尿病性血管合併症での意義2007

    • Author(s)
      林登志雄(他2名1番目)
    • Organizer
      第11回日本心血管内分泌代謝学会
    • Place of Presentation
      東京
    • Year and Date
      20071116-17
  • [Presentation] 内皮細胞老化はNOで阻害される-動脈硬化症での意義-2007

    • Author(s)
      林登志雄(他2名1番目)
    • Organizer
      第49回日本老年医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20070620-22
  • [Presentation] 肥満・糖尿病における心血管障害の進展抑制-各種高脂血症薬、降圧薬の作用について-2007

    • Author(s)
      林登志雄
    • Organizer
      第50回日本糖尿病学会学術集会 ランチョンセミナー
    • Place of Presentation
      仙台
    • Year and Date
      20070524-27
  • [Presentation] 内皮細胞老化はNOで阻害されるー糖尿病性血管合併症での意義2007

    • Author(s)
      林登志雄(他2名1番目)
    • Organizer
      第50回日本糖尿病学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      20070524-26
  • [Presentation] Endothelial sensescence is prevented by NO-The role in atherosclerosis-2007

    • Author(s)
      林登志雄
    • Organizer
      第7回日本NO学会 シンポジウム
    • Place of Presentation
      大津
    • Year and Date
      20070500
  • [Presentation] Nitric oxide and endothelial cell senescence2007

    • Author(s)
      Hayashi T
    • Organizer
      AVDRC Symposium on vascular aging and atherosclerosis (Invited special lecture)
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2007-11-16
  • [Presentation] 各種高脂血症薬の糖尿病合併心血管病進展予防効果の検討-厳格な脂質及び糖代謝制御の必要性について-2007

    • Author(s)
      林登志雄
    • Organizer
      第39回日本動脈硬化学会総会シンポジウム 糖尿病/耐糖能障害と動脈硬化
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-14
  • [Presentation] 内皮細胞の老化はNOにより阻害される-閉経及び糖尿病に関連した動脈硬化症での意義2007

    • Author(s)
      林登志雄
    • Organizer
      第39回日本動脈硬化学会総会シンポジウム血管細胞老化と動脈硬化
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-14
  • [Book] Free radicals as atherosclerotic risk-The relation of NO Louis J Ignarro NO 2^<nd>2009

    • Author(s)
      *Toshio Hayashi, Akihisa Iguchi
    • Publisher
      Edition Elsevier
  • [Book] 老化的自然科学他2008

    • Author(s)
      林登志雄
    • Total Pages
      3-34
    • Publisher
      雲南出版集団公司、雲南人民出版社
  • [Book] 現代老年学(これからの老年学 : 中国語版)2008

    • Author(s)
      井口昭久/林登志雄/余沢雲
    • Total Pages
      3-34
    • Publisher
      雲南出版集団公司、雲南人民出版社
  • [Book] 尿失禁2008

    • Author(s)
      林登志雄
    • Total Pages
      74-82
    • Publisher
      南山堂 東京
  • [Patent(Industrial Property Rights)] シトルリンまたはその塩およびアルギニンまたはその塩を有効成分として含有する、即効性アルギニン血中濃度上昇型経口剤2008

    • Inventor(s)
      林登志雄 (他2名1番目)
    • Industrial Property Rights Holder
      林登志雄 (他2名1番目)
    • Industrial Property Number
      PCT /JP2008/068505(WO)
    • Filing Date
      2008-10-10
    • Overseas

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi