2009 Fiscal Year Final Research Report
Mutations in genes encoding the K_<ATP> channel and their influence on efficacy of insulinotropic agents.
| Project/Area Number |
19591047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto University |
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Principal Investigator |
NAGASHIMA Kazuaki Kyoto University, 大学院・医学研究科, 助教 (40324628)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 糖尿病学 |
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| Research Abstract |
Kir6.2, together with SUR1, forms an ATP-sensitive potassium (K_<ATP>) channel that plays a key role in insulin secretion from pancreatic ss-cells. In this study, we carried out functional analyses including electrophysiological analysis, and found significant differences in ATP-sensitivity, sulfonylurea-sensitivity, and membrane surface expression among the mutants. Furthermore, it is possible to evaluate the potential efficacy of these insulinotropic agents in patients with the mutation by using in vitro analyses.
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[Journal Article] Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species2010
Author(s)
Fujita Y, Hosokawa M, Fujimoto S, Mukai E, Abudukadier A, Obara A, Ogura M, Nakamura Y, Toyoda K, Nagashima K, Seino Y, Inagaki N.
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Journal Title
Peer Reviewed
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[Journal Article] Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism2010
Author(s)
Shimodahira M, Fujimoto S, Mukai E, Nakamura Y, Nishi Y, Sasaki M, Sato Y, Sato H, Hosokawa M, Nagashima K, Seino Y, Inagaki N.
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Journal Title
J Endocrinol 204(1)
Pages: 37-46
Peer Reviewed
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[Journal Article] Sulfonylurea and glinide reduce insulin content, functional expression of KATP channels, and accelerate apoptotic β-cell death in the chronic phase2007
Author(s)
Takahashi A, Nagashima K, Hamasaki A, Kuwamura N, Kawasaki Y, Ikeda H, Yamada Y, Inagaki N, Seino Y.
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Journal Title
Diabetes Res Clin Pract 77(3)
Pages: 343-50
Peer Reviewed
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